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13 papers found.
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SWI/SNF-Komplex-assoziierte Tumordispositions-Syndrome

Universit?tsklinikum Hamburg-Eppendorf Klinik und Poliklinik f?r P?diatr. H?matologie und Onkologie Martinistr. 52, 20246 Hamburg Referenzdiagnostik Neuropathologie (AT/RT): Prof. Dr. med. Martin ... Hasselblatt Universit?tsklinikum M?nster Institut f?r Neuropathologie Pottkamp 2, 48149 M?nster Referenzdiagnostik Pathologie (RTK und MRT): Universit?tsklinikum Schleswig-Holstein, Campus Kiel Institut f?r

The hereditary nature of small cell carcinoma of the ovary, hypercalcemic type: two new familial cases

Small cell carcinoma of the ovary, hypercalcemic type, (SCCOHT) is the most common undifferentiated ovarian cancer in women aged under 40 years. SCCOHT is a monogenic disease, characterized by germline and somatic SMARCA4 mutations. Recent studies have stressed its morphological and clinical similarity to malignant rhabdoid tumours, which are usually caused by mutations in the...

The histone deacetylase inhibitor SAHA acts in synergism with fenretinide and doxorubicin to control growth of rhabdoid tumor cells

Background Rhabdoid tumors are highly aggressive malignancies affecting infants and very young children. In many instances these tumors are resistant to conventional type chemotherapy necessitating alternative approaches. Methods Proliferation assays (MTT), apoptosis (propidium iodide/annexin V) and cell cycle analysis (DAPI), RNA expression microarrays and western blots were...

Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity

Three histological variants are known within the family of embryonal rosette-forming neuroepithelial brain tumors. These include embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma (EBL), and medulloepithelioma (MEPL). In this study, we performed a comprehensive clinical, pathological, and molecular analysis of 97 cases of these rare brain...

ARGININE CHALLENGE UNRAVELS PERSISTENT DISTURBANCES OF UREA CYCLE AND GLUCONEOGENESIS IN ABSTINENT ALCOHOLICS

Aims: Data on recovery from hormonal and metabolic sequelae of alcoholism in strictly controlled alcohol abstinence are mainly restricted to short-term abstention. Our previous findings of persistently decreased plasma and urinary urea concentrations in long-term abstinent alcoholics prompted us to further elucidate this unexplained phenomenon. Methods: The response of...

Platelet-derived growth factor receptor expression and amplification in choroid plexus carcinomas

Platelet-derived growth factor (PDGF) receptor signaling has been implicated in the development of glial tumors, but not yet been examined in choroid plexus carcinomas, pediatric tumors with dismal prognosis for which novel treatment options would be desirable. Therefore, protein expression of PDGF receptors α and β as well as amplification status of the respective genes, PDGFRA...

PERSISTENT DISTURBANCE OF THE HYPOTHALAMIC–PITUITARY–GONADAL AXIS IN ABSTINENT ALCOHOLIC MEN

Aims: Testosterone synthesis in chronic alcoholics is affected by a variety of mechanisms. Little is known about the reversibility of these changes upon abstinence and available data on circulating hormone levels are incomplete and inconsistent. Methods: Serum concentrations of free testosterone, total testosterone, and luteinizing hormone (LH) were determined in 18 male non...

ATYPICAL TERATOID RHABDOID TUMOUR

ALTERATIONS AND SHORTER SURVIVAL AS COMPARED TO SMARCB1 DEFICIENT AT/RT Martin Hasselblatt 31 Swabian Childrens' Cancer Center, Childrens' Hospital Augsburg and EU-RHAB Registry working group , Augsburg

ATYPICAL TERATOID RHABDOID TUMOR (ATRT)

FORMALIN-FIXED TISSUES Martin Hasselblatt 3 University Children's Hospital of Essen , Essen , Germany 4 Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine ... INTERNATIONAL CHOROID PLEXUS TUMOR REGISTRY CPT-SIOP Martin Hasselblatt 6 Department of Pediatric Hematology and Oncology, Justus Liebig University , Giessen, Giessen , Germany 7 Department of Pediatrics

Dissecting the genomic complexity underlying medulloblastoma

Research journals • PubMed • Google ScholarSearch for Michael C. Frühwald in:Nature Research journals • PubMed • Google ScholarSearch for Martin Hasselblatt in:Nature Research journals • PubMed • Google

RARE TUMORS

Primary Leptomeningeal Anaplastic Oligodendroglioma (PLAO) is a very rare tumor that grows in the subarachnoid space with no obvious findings of intraparenchymal mass lesion. Here we report an 11-year-old girl who was diagnosed as PLAO with temporal bone invasion. She has a history of shunted hydrocephalus of unknown etiology since the age of 8. Computed tomography (CT) scan had...

Pediatrics Clinical Research

Very rare tumors, such as choroid plexus tumors, require large referral populations to generate meaningful clinical data. In the year 2000, the International Society of Pediatric Oncology (SIOP) started a program including a prospective registry, a standard-of-care recommendation, and a randomized treatment protocol (CPT-SIOP-2000). Data from 188 tumors were registered by...

MEDULLOBLASTOMA

BACKGROUND: LMD in children with recurrent medulloblastoma and other PNETs carries a poor prognosis and novel therapies are urgently needed to improve disease control. Somatostatin receptor-2 (SSR-2)is overexpressed in medulloblastoma and other central PNETs and can serve as a target for radionuclide tagged somatostatin analogues like 177Lu-DOTA-TATE that has shown considerable...