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External validation of four dementia prediction models for use in the general community-dwelling population: a comparative analysis from the Rotterdam Study

To systematically review the literature for dementia prediction models for use in the general population and externally validate their performance in a head-to-head comparison. We selected four prediction models for validation: CAIDE, BDSI, ANU-ADRI and DRS. From the Rotterdam Study, 6667 non-demented individuals aged 55 years and older were assessed between 1997 and 2001...

Measures of subclinical cardiac dysfunction and increased filling pressures associate with pulmonary arterial pressure in the general population: results from the population-based Rotterdam Study

Netherlands 2 Maarten J. G. Leening 3 Medizinische Klinik II, University of Giessen and Marburg Lung Center (UGMLC) - Member of the German Center for Lung Research (DZL) , Giessen , Germany 4 Inspectorate for ... systolic pressure; Epidemiology; Population-based; Pulmonary hypertension; Heart failure - Ryan J. Billar and Maarten J. G. Leening contributed equally to this work. Henning Gall and Janine F. Felix

Use of antidepressants and the risk of myocardial infarction in middle-aged and older adults: a matched case-control study

Purpose Antidepressants, specifically selective serotonin reuptake-inhibiting antidepressants (SSRIs), decrease platelet activation and aggregation in in vitro experiments and could therefore decrease the risk of myocardial infarction (MI). However, prior studies addressing this hypothesis showed contradictory results. Our purpose was to investigate the association between the...

Prevalence of Pulmonary Hypertension in the General Population: The Rotterdam Study

Background Pulmonary hypertension is characterized by increased pulmonary artery pressure and carries an increased mortality. Population-based studies into pulmonary hypertension are scarce and little is known about its prevalence in the general population. We aimed to describe the distribution of echocardiographically-assessed pulmonary artery systolic pressure (ePASP) in the...

Methods of data collection and definitions of cardiac outcomes in the Rotterdam Study

The prevalence of cardiovascular diseases is rising. Therefore, adequate risk prediction and identification of its determinants is increasingly important. The Rotterdam Study is a prospective population-based cohort study ongoing since 1990 in the city of Rotterdam, The Netherlands. One of the main targets of the Rotterdam Study is to identify the determinants and prognosis of...