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Search: authors:"Macaulay Onuigbo"

3 papers found.
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CELL PHYSIOLOGY AND ELECTROLYTES

Introduction and Aims: Physiologic ion channels take advantage of the different ionic diameters to selectively filter the requisite ion. For example, although potassium (K+) and sodium (Na+) ions are similar in size (3.0 Å and 2.3 Å, respectively [Volkov 1997]), K+ channels discriminate between K+ and Na+ by a factor of 10,000 (Doyle 1998) using a selectivity filter. To pass...

CKD LAB METHODS, PROGRESSION & RISK FACTORS 2

Introduction and Aims: Despite decades of research, our complete understanding of the determinants and natural history of CKD-ESRD progression is immature. CKD to ESRD progression is unanimously and classically depicted as a predictable, linear, progressive and time-dependent decline in renal function, ultimately leading to ESRD and the need for RRT. The National Kidney...

CKD GENERAL AND CLINICAL EPIDEMIOLOGY 1

Introduction and Aims: In hemodialysis (HD) patients low pre-HD serum sodium (SNa+) and high Na+ gradients have been associated with higher mortality. Increased pre-HD SNa+ variability has been linked to mortality, while stable SNa+ levels are associated with better survival. Here we investigated the joint relationship of SNa+ variability (expressed as standard deviation, SD) and...