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MicroRNAs miR-221 and miR-222: a new level of regulation in aggressive breast cancer

MicroRNAs (miRNAs) are crucial in the initiation and progression of tumors. A recent study has reported that the miRNAs miR-221 and miR-222 are involved in the promotion of an aggressive basal-like phenotype in breast cancer, functioning downstream of the RAS pathway and triggering epithelial-to-mesenchymal transition. These new insights into the roles of miR-221/222 in breast...

OncomiR-10b hijacks the small molecule inhibitor linifanib in human cancers

, Waltham, 02451, MA, USA Roxana S. Redis Present address: ProQR Therapeutics N.V., 2333 CK, Leiden, The Netherlands Paloma del C. Monroig-Bosque, Maitri Y. Shah and Xiao Fu contributed equally ... . AffiliationsDepartment of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USAPaloma del C. Monroig-Bosque, Maitri Y. Shah, Xiao Fu, Enrique Fuentes-Mattei, Hui Ling, Nazila