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Hydrogen Peroxide–Inducible Clone-5 Regulates Mesangial Cell Proliferation in Proliferative Glomerulonephritis in Mice

Hydrogen peroxide-inducible clone-5 (Hic-5) is a transforming growth factor (TGF)-β1-inducible focal adhesion protein. We previously demonstrated that Hic-5 was localized in mesangial cells and its expression was associated with glomerular cell proliferation and matrix expansion in human and rat glomerulonephritis (GN). In the present study, we first assessed the role of Hic-5 in...

Urinary Angiotensinogen as a Biomarker of Nephropathy in Childhood

School, Kuramoto-cho 3-18-15, Tokushima 770-8503, Japan Received 14 March 2011; Revised 21 June 2011; Accepted 21 June 2011 Academic Editor: Michel Fischbach Copyright © 2011 Maki Urushihara and Shoji

Evidence-based clinical practice guidelines for IgA nephropathy 2014

2014. Committee chairman: Yukio Yuzawa. Committee members: Maki Urushihara, Shoji Kagami, Ritsuko Katafuchi, Hiroshi Kitamura, Hiroyuki Komatsu, Masashi Goto, Shuji Kondo, Mitsuhiro Sato, Kazuo Takahashi

A case of infantile systemic lupus erythematosus with severe lupus nephritis and EBV infection

Infantile systemic lupus erythematosus (iSLE) is extremely rare. Patients with iSLE usually become severely unwell and have poor prognosis. Epstein–Barr virus (EBV) infection has been implicated in the development of SLE in both adults and children. Recently, we experienced a case of iSLE with severe lupus nephritis (LN) and EBV infection. A 14-month-old Japanese boy was...

Nitrosonifedipine Ameliorates the Progression of Type 2 Diabetic Nephropathy by Exerting Antioxidative Effects

Diabetic nephropathy (DN) is the major cause of end-stage renal failure. Oxidative stress is implicated in the pathogenesis of DN. Nitrosonifedipine (NO-NIF) is a weak calcium channel blocker that is converted from nifedipine under light exposure. Recently, we reported that NO-NIF has potential as a novel antioxidant with radical scavenging abilities and has the capacity to treat...

Glomerular angiotensinogen protein is enhanced in pediatric IgA nephropathy

Enhanced intrarenal renin-angiotensin system (RAS) is implicated in the development and progression of renal injury. To investigate whether angiotensinogen (AGT) expression is involved in glomerular RAS activity and glomerular injury, we examined glomerular AGT expression and its correlation with expression of other RAS components, and levels of glomerular injury in samples from...

Urinary angiotensinogen reflects the activity of intrarenal renin–angiotensin system in patients with IgA nephropathy

Background. A potential contribution of local activation of the renin–angiotensin system (RAS) to the pathogenesis of renal injury has been indicated by evidence for blood pressure-independent renoprotective effects of angiotensin II (AngII) receptor blockers (ARBs). The present study was performed to test the hypothesis that urinary angiotensinogen provides a specific index of...

Role of integrin-linked kinase in epithelial–mesenchymal transition in crescent formation of experimental glomerulonephritis

Background. Glomerular parietal epithelial–mesenchymal transition (EMT) is a key event in crescent formation of glomerulonephritis (GN). Integrin-linked kinase (ILK) is an integrin cytoplasmic-binding protein that has been implicated in the regulation of cell adhesion, extracellular matrix organization and EMT. Transforming growth factor-β (TGF-β) is involved in the induction and...

Glomerular distribution and gelatinolytic activity of matrix metalloproteinases in human glomerulonephritis

Background. Matrix metalloproteinases (MMPs) have been implicated in the development of glomerular injury in rat experimental glomerulonephritis (GN). However, the significance of MMPs in human GN remains obscure. In order to evaluate the role of MMPs in human GN, we examined the glomerular distribution and gelatinolytic activities of MMP‐2 and MMP‐9 in human GN. Methods. We...