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Implementing hybrid LCA routines in an input–output virtual laboratory

Hybrid life cycle assessment (LCA) has been developed for almost 40 years, but its applications are still limited to certain products/industries. This study endeavors to expand the accessibility of hybrid LCA from specialists to practitioners by developing a streamlined and semi-automated hybrid LCA data compilation routine in an input–output virtual laboratory. Data from the...

Combination therapy with protein kinase inhibitor H89 and Tetrandrine elicits enhanced synergistic antitumor efficacy

Tetrandrine, a bisbenzylisoquinoline alkaloid that was isolated from the medicinal plant Stephania tetrandrine S. Moore, was recently identified as a novel chemotherapy drug. Tetrandrine exhibited a potential antitumor effect on multiple types of cancer. Notably, an enhanced therapeutic efficacy was identified when tetrandrine was combined with a molecularly targeted agent. H89...

The plant alkaloid tetrandrine inhibits metastasis via autophagy-dependent Wnt/β-catenin and metastatic tumor antigen 1 signaling in human liver cancer cells

 Zhang1, Ting Liu1, Man Yu, Kangdi Li1 and Wenhua Li1Email author Journal of Experimental & Clinical Cancer Research201837:7 https://doi.org/10.1186/s13046-018-0678-6 ©  The Author(s). 2018 Received

Left Ventricular Stiffness in Adolescents and Young Adults with Repaired Tetralogy of Fallot

references Author information AffiliationsDepartment of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaClement Kwong-man Yu, Wilfred Hing-sang ... Wong, Vivian Wing-yi Li & Yiu-fai Cheung AuthorsSearch for Clement Kwong-man Yu in:Nature Research journals • PubMed • Google Scholar Search for Wilfred Hing-sang Wong in:Nature Research journals

Nonalcoholic Fatty Liver Disease: Correlation of the Liver Parenchyma Fatty Acid with Intravoxel Incoherent Motion MR Imaging–An Experimental Study in a Rat Model

Purpose To prospectively evaluate the changes in fatty acid concentration after administrating a 60% high-fat diet to a non-alcoholic fatty liver disease rat model and to perform a correlation analysis between fatty acid with molecular diffusion (Dtrue), perfusion-related diffusion (Dfast), and perfusion fraction (Pfraction). Material and Methods This prospective study was...

The effect of chemotherapeutic agents on tumor vasculature in subcutaneous and orthotopic human tumor xenografts

Background The growth of solid tumors and their regrowth after treatment is dependent upon functional tumor vasculature. Some chemotherapeutic agents have shown anti-angiogenic properties but there are limited studies of the effect of chemotherapy on tumor vasculature. Here we investigate the effect of paclitaxel, 5-fluorouracil (5-FU) and doxorubicin on tumor vasculature in...

Effects of Sulfurization Pressure on the Conversion Efficiency of Cosputtered Cu2ZnSnS4 Thin Film Solar Cells

We report herein Cu2ZnSnS4 (CZTS) thin film solar cells with 6.75% conversion efficiency, without an antireflection coating. The CZTS precursors have been prepared by cosputtering using three different targets on Mo-coated substrates: copper (Cu), tin sulfide (SnS), and zinc (Zn). The postsulfurization was carried out at different pressures in a H2S/N2 environment at 550°C for...

Carotid plaque and bone density and microarchitecture in psoriatic arthritis: the correlation with soluble ST2

Psoriatic arthritis (PsA) patients have increased risk of both atherosclerosis and osteoporosis. Previous studies revealed that IL-33/ST2 axis may be related to both conditions; however, these associations were never evaluated in a single patients’ group. Here we explored the association among plasma levels of IL-33 and its decoy receptor soluble ST2 (sST2), carotid plaque...

Prescription of Chinese Herbal Medicine in Pattern-Based Traditional Chinese Medicine Treatment for Depression: A Systematic Review

treatment for depression. 2. Materials and Methods The present study was part of our systematic review on Chinese herbal medicine for depression [11, 20]. Two researchers (Ka-Yan Ng and Yee-Man Yu ... publications and by consultation with the senior authors (Wing-Fai Yeung and Ka-Fai Chung). One author extracted the data (Ka-Yan Ng) and the other (Yee-Man Yu) checked the extracted data. For each study, the

Prescription of Chinese Herbal Medicine in Pattern-Based Traditional Chinese Medicine Treatment for Depression: A Systematic Review

Yeung and Ka-Fai Chung). One author extracted the data (Ka-Yan Ng) and the other (Yee-Man Yu) checked the extracted data. For each study, the following variables were extracted: study design, sample size ... -based CHM treatment for depression. 2. Materials and Methods The present study was part of our systematic review on Chinese herbal medicine for depression [11, 20]. Two researchers (Ka-Yan Ng and Yee-Man

The Prevalence and Prognosis of Resistant Hypertension in Patients with Heart Failure

Background Resistant hypertension is associated with adverse clinical outcome in hypertensive patients. However, the prognostic significance of resistant hypertension in patients with heart failure remains uncertain. Methods and Results The 1 year survival and heart failure re-hospitalization rate of 1288 consecutive patients admitted to a university hospital for either newly...

Effect of Growth Parameters and Annealing Atmosphere on the Properties of Cu2ZnSnS4 Thin Films Deposited by Cosputtering

Cu2ZnSnS4 (CZTS) thin films were deposited using the cosputtering technique. The growth parameters, such as working pressure, target powers, and postannealing atmosphere, were optimized for CZTS films deposition. A comparative study between post annealing using sulfur vapor in a quartz tube furnace and sulfurization chamber using H2S gas was carried out to optimize the kesterite...

The Fission Yeast GATA Factor, Gaf1, Modulates Sexual Development via Direct Down-Regulation of ste11+ Expression in Response to Nitrogen Starvation

Gaf1 is the first GATA family zinc-finger transcription factor identified in Schizosaccharomyces pombe. Here, we report that Gaf1 functions as a negatively acting transcription factor of ste11+, delaying the entrance of cells exposed to transient nitrogen starvation into the meiotic cycle. gaf1Δ strains exhibited accelerated G1-arrest upon nitrogen starvation. Moreover, gaf1...

Cumulative inflammatory burden is independently associated with increased arterial stiffness in patients with psoriatic arthritis: a prospective study

Introduction The aim of this study was to examine whether the cumulative inflammatory burden is associated with an increase in arterial stiffness in a prospective cohort of psoriatic arthritis (PsA) patients. Methods In total, 72 PsA patients were followed for a median of 6.5 years. Cumulative inflammatory burden was represented by the cumulative averages of repeated measures of...

Small for Gestational Age and Age at Puberty: Evidence From Hong Kong's “Children of 1997” Birth Cohort

); Department of Mathematics, the Hong Kong University of Science and Technology, Kowloon, Hong Kong Special Administrative Region, China (Man-Yu Wong); and CUNY School of Public Health at Hunter College, New

β-catenin/cyclin D1 mediated development of suture mesenchyme in calvarial morphogenesis

Background Mouse genetic study has demonstrated that Axin2 is essential for calvarial development and disease. Haploid deficiency of β-catenin alleviates the calvarial phenotype caused by Axin2 deficiency. This loss-of-function study provides evidence for the requirement of β-catenin in exerting the downstream effects of Axin2. Results Here we utilize a gain-of-function analysis...

Early Time-Dependent Dynamic Changes of TBET and GATA3 mRNA Expressions in Patients with Acute Coronary Syndrome

Background. T-box expressed in T cells (TBET) and guanine adenine thymine adenine sequence-binding protein 3 (GATA3) play important roles in the differentiation of Th1 and Th2 subsets, which contributes to the progression of acute coronary syndrome (ACS). Objective. This study aimed to investigate the temporal change of TBET/GATA3 mRNA ratio in ACS. Methods. Thirty-three patients...

Early Time-Dependent Dynamic Changes of TBET and GATA3 mRNA Expressions in Patients with Acute Coronary Syndrome

Background. T-box expressed in T cells (TBET) and guanine adenine thymine adenine sequence-binding protein 3 (GATA3) play important roles in the differentiation of Th1 and Th2 subsets, which contributes to the progression of acute coronary syndrome (ACS). Objective. This study aimed to investigate the temporal change of TBET/GATA3 mRNA ratio in ACS. Methods. Thirty-three patients...

Deficiency of Smad7 Enhances Cardiac Remodeling Induced by Angiotensin II Infusion in a Mouse Model of Hypertension

Smad7 has been shown to negatively regulate fibrosis and inflammation, but its role in angiotensin II (Ang II)-induced hypertensive cardiac remodeling remains unknown. Therefore, the present study investigated the role of Smad7 in hypertensive cardiopathy induced by angiotensin II infusion. Hypertensive cardiac disease was induced in Smad7 gene knockout (KO) and wild-type (WT...