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27 papers found.
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Relationship between normalized distributional pattern and functional outcome in patients with acute cardiogenic cerebral embolism

Hospital for his excellent support in collecting the imaging data used in this research. Author Contributions Conceptualization: Masatoshi Takagaki, Manabu Kinoshita. Data curation: Masatoshi Takagaki ... . Formal analysis: Atsushi Kawaguchi. Funding acquisition: Masatoshi Takagaki. Investigation: Masatoshi Takagaki, Atsushi Kawaguchi. Methodology: Manabu Kinoshita. Resources: Masatoshi Takagaki, Akira

Characteristics and outcomes of elderly patients with diffuse gliomas: a multi-institutional cohort study by Kansai Molecular Diagnosis Network for CNS Tumors

IntroductionThis study investigates the current state of clinical practice and molecular analysis for elderly patients with diffuse gliomas and aims to elucidate treatment outcomes and prognostic factors of patients with glioblastomas.MethodsWe collected elderly cases (≥ 70 years) diagnosed with primary diffuse gliomas and enrolled in Kansai Molecular Diagnosis Network for CNS...

Feasibility of Quantification of Intracranial Aneurysm Pulsation with 4D CTA with Manual and Computer-Aided Post-Processing

Background and Purpose The analysis of the pulsation of unruptured intracranial aneurysms might improve the assessment of their stability and risk of rupture. Pulsations can easily be concealed due to the small movements of the aneurysm wall, making post-processing highly demanding. We hypothesized that the quantification of aneurysm pulsation is technically feasible and can be...

Activation and increase of radio-sensitive CD11b+ recruited Kupffer cells/macrophages in diet-induced steatohepatitis in FGF5 deficient mice

We have recently reported that Kupffer cells consist of two subsets, radio-resistant resident CD68+ Kupffer cells and radio-sensitive recruited CD11b+ Kupffer cells/macrophages (Mφs). Non-alcoholic steatohepatitis (NASH) is characterized not only by hepatic steatosis but also chronic inflammation and fibrosis. In the present study, we investigated the immunological mechanism of...

Introduction of High Throughput Magnetic Resonance T2-Weighted Image Texture Analysis for WHO Grade 2 and 3 Gliomas

Reports have suggested that tumor textures presented on T2-weighted images correlate with the genetic status of glioma. Therefore, development of an image analyzing framework that is capable of objective and high throughput image texture analysis for large scale image data collection is needed. The current study aimed to address the development of such a framework by introducing...

Mouse CD11b+Kupffer Cells Recruited from Bone Marrow Accelerate Liver Regeneration after Partial Hepatectomy

TNF and Fas/FasL are vital components, not only in hepatocyte injury, but are also required for hepatocyte regeneration. Liver F4/80+Kupffer cells are classified into two subsets; resident radio-resistant CD68+cells with phagocytic and bactericidal activity, and recruited radio-sensitive CD11b+cells with cytokine-producing capacity. The aim of this study was to investigate the...

Treatment of Irradiated Mice with High-Dose Ascorbic Acid Reduced Lethality

Ascorbic acid is an effective antioxidant and free radical scavenger. Therefore, it is expected that ascorbic acid should act as a radioprotectant. We investigated the effects of post-radiation treatment with ascorbic acid on mouse survival. Mice received whole body irradiation (WBI) followed by intraperitoneal administration of ascorbic acid. Administration of 3 g/kg of ascorbic...

Involvement of the TNF and FasL Produced by CD11b Kupffer Cells/Macrophages in CCl4-Induced Acute Hepatic Injury

Kinoshita 0 Shuhji Seki 0 Rajesh Mohanraj, UAE University, Faculty of Medicine & Health Sciences, United Arab Emirates 0 1 Department of Immunology and Microbiology, National Defense Medical College , Namiki

Antitumor Immunity Produced by the Liver Kupffer Cells, NK Cells, NKT Cells, and CD8

Mouse and human livers contain innate immune leukocytes, NK cells, NKT cells, and macrophage-lineage Kupffer cells. Various bacterial components, including Toll-like receptor (TLR) ligands and an NKT cell ligand (α-galactocylceramide), activate liver Kupffer cells, which produce IL-1, IL-6, IL-12, and TNF. IL-12 activates hepatic NK cells and NKT cells to produce IFN-γ, which...

Antitumor Immunity Produced by the Liver Kupffer Cells, NK Cells, NKT Cells, and CD8

+ CD122+ T Cells Shuhji Seki, Hiroyuki Nakashima, Masahiro Nakashima, and Manabu Kinoshita Department of Immunology and Microbiology, National Defense Medical College, Namiki-3-2, Tokorozawa, Saitama 358

The Effect of Synthetic C-Reactive Protein on the In Vitro Immune Response of Human PBMCs Stimulated with Bacterial Reagents

Synthetic C-reactive protein (CRP) rescues mice from lethal endotoxin shock or bacterial infection by suppressing tumor necrosis factor (TNF-α), but in turn, enhances Kupffer cell phagocytic activity. We herein assessed the influence of CRP in human peripheral blood mononuclear cells (PBMCs). When human PBMCs were stimulated in vitro with penicillin-treated Streptococcus pyogenes...

Activation of CD11b+ Kupffer Cells/Macrophages as a Common Cause for Exacerbation of TNF/Fas-Ligand-Dependent Hepatitis in Hypercholesterolemic Mice

We have reported that the mouse hepatic injury induced by either α-galactosylceramide (α-GalCer) or bacterial DNA motifs (CpG-ODN) is mediated by the TNF/NKT cell/Fas-ligand (FasL) pathway. In addition, F4/80+ Kupffer cells can be subclassified into CD68+ subset with a phagocytosing capacity and CD11b+ subset with a TNF-producing capacity. CD11b+ subset increase if mice are fed...

CD166/Activated leukocyte cell adhesion molecule is expressed on glioblastoma progenitor cells and involved in the regulation of tumor cell invasion

For improvement of prognosis for glioblastoma patients, which remains poor, identification and targeting of glioblastoma progenitor cells are crucial. In this study, we found that the Cluster of Differentiation (CD)166/activated leukocyte cell adhesion molecule (ALCAM) was highly expressed on CD133+ glioblastoma progenitor cells. ALCAM+CD133+ cells were highly enriched with tumor...

Different spatial distribution between germinal center B and non-germinal center B primary central nervous system lymphoma revealed by magnetic resonance group analysis

Background MRI group analysis is a powerful tool for elucidating pathological conditions in the brain that are challenging to reveal from single subject analysis. This research aimed to elucidate special distribution characteristics of primary central nervous system lymphoma (PCNSL) within the brain with respect to molecular marker expression patterns.

Photodynamic Therapy Can Induce a Protective Innate Immune Response against Murine Bacterial Arthritis via Neutrophil Accumulation

Background Local microbial infections induced by multiple-drug-resistant bacteria in the orthopedic field can be intractable, therefore development of new therapeutic modalities is needed. Photodynamic therapy (PDT) is a promising alternative modality to antibiotics for intractable microbial infections, and we recently reported that PDT has the potential to accumulate neutrophils...

Pretreatment with Ascorbic Acid Prevents Lethal Gastrointestinal Syndrome in Mice Receiving a Massive Amount of Radiation

While bone marrow or stem cell transplantation can rescue bone marrow aplasia in patients accidentally exposed to a lethal radiation dose, radiation-induced irreversible gastrointestinal damage (GI syndrome) is fatal. We investigated the effects of ascorbic acid on radiation-induced GI syndrome in mice. Ascorbic acid (150 mg/kg/day) was orally administered to mice for 3 days, and...

Interleukin-18 Protects Splenectomized Mice from Lethal Streptococcus pneumoniae Sepsis Independent of Interferon-γ by Inducing IgM Production

The mechanism of the susceptibility of splenectomized mice to Streptococcus pneumoniae infection and the therapeutic effect of interleukin (IL)–18 were investigated. We demonstrated that, although S. pneumoniae challenge induced IL-12 production, it did not induce either interferon (IFN)–γ or IL-18 production in mice with or without a splenectomy. Liver mononuclear cells...

RADIOLOGY

-AMINOLEVULINIC ACID-INDUCED FLUORESCENCE ARE SEPARATE INDEX MARKERS OF CELL DENSITY IN GLIOMAS: A STEREOTACTIC IMAGE-HISTOLOGICAL ANALYSIS Hideyuki Arita , Manabu Kinoshita, Naoki Kagawa, Yasunori Fujimoto, Naoya ... . ELEVATED CITRATE IN PEDIATRIC ASTROCYTOMAS WITH MALIGNANT PROGRESSION Stefan Bluml 6 C-METHIONINE PET CAN ACCURATELY DETECT GLIOMA INFILTRATION IN THE MR T2-HYPER-INTENSE AREA Manabu Kinoshita, Hideyuki

CLIN-IMMUNOTHERAPY/BIOLOGIC THERAPIES

0 IT-02. TUMOR-INFILTRATING LYMPHOCYTES AND IMMUNE ESCAPE IN HUMAN MALIGNANT GLIOMAS AFTER WT1 VACCINATION Yasuyoshi Chiba , Naoya Hashimoto, Naoki Kagawa, Manabu Kinoshita, Noriyuki Kijima, Ryuichi ... FOR NEWLY DIAGNOSED GLIOBLASTOMAS; PHASE I CLINICAL TRIAL OF COMBINATION WITH TEMOZOLOMIDE Naoya Hashimoto, Akihiro Tsuboi, Yasuyoshi Chiba, Noriyuki Kijima, Yoshihiro Oka, Yusuke Oji, Manabu Kinoshita

GERM CELL TUMOURS

BACKGROUND: Radiation treatment of GCT brain, in particular germinomas which are highly radio-sensitive,over the years has evolved from the cranio-spinal irradiation(CSI) to more conformal treatment like whole ventricle radiation followed by tumor bed boost (WV + TB), without compromising the results. We report our experience of treatment outcome of patients treated consecutively...