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Search: authors:"Manickam Yogavel"

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Structural and functional attributes of malaria parasite diadenosine tetraphosphate hydrolase

Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Road, New Delhi, 110067, IndiaArvind Sharma, Manickam Yogavel & Amit Sharma AuthorsSearch for Arvind Sharma ... in:Nature Research journals • PubMed • Google ScholarSearch for Manickam Yogavel in:Nature Research journals • PubMed • Google ScholarSearch for Amit Sharma in:Nature Research journals • PubMed • Google

An Appended Domain Results in an Unusual Architecture for Malaria Parasite Tryptophanyl-tRNA Synthetase

Specific activation of amino acids by aminoacyl-tRNA synthetases (aaRSs) is essential for maintaining fidelity during protein translation. Here, we present crystal structure of malaria parasite Plasmodium falciparum tryptophanyl-tRNA synthetase (Pf-WRS) catalytic domain (AAD) at 2.6 Å resolution in complex with L-tryptophan. Confocal microscopy-based localization data suggest...

Structure, localization and histone binding properties of nuclear-associated nucleosome assembly protein from Plasmodium falciparum

Background Nucleosome assembly proteins (NAPs) are histone chaperones that are crucial for the shuttling and incorporation of histones into nucleosomes. NAPs participate in the assembly and disassembly of nucleosomes thus contributing to chromatin structure organization. The human malaria parasite Plasmodium falciparum contains two nucleosome assembly proteins termed PfNapL and...