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Bilateral effects of unilateral cerebellar lesions as detected by voxel based morphometry and diffusion imaging

analysis: Giusy Olivito, Michael Dayan. Funding acquisition: Maria Leggio. Investigation: Giusy Olivito, Michael Dayan, Valentina Battistoni. Methodology: Michael Dayan, Mara Cercignani. Project ... administration: Marco Molinari, Maria Leggio, Marco Bozzali. 12 / 15 Resources: Marco Molinari, Maria Leggio, Marco Bozzali. Supervision: Mara Cercignani, Marco Molinari, Maria Leggio, Marco Bozzali. Writing

Comparing resting state fMRI de-noising approaches using multi- and single-echo acquisitions

: Prof. Mara Cercignani is a past Academic Editor of PLOS ONE. This does not alter our adherence to PLOS ONE policies on sharing data and materials. Introduction Resting state functional MRI (rfMRI) is a

Amygdala functional connectivity as a longitudinal biomarker of symptom changes in generalized anxiety

Generalized anxiety disorder (GAD) is characterized by excessive worry, autonomic dysregulation and functional amygdala dysconnectivity, yet these illness markers have rarely been considered together, nor their interrelationship tested longitudinally. We hypothesized that an individual’s capacity for emotion regulation predicts longer-term changes in amygdala functional...

Brain Connectivity Changes in Autosomal Recessive Parkinson Disease: A Model for the Sporadic Form

Biallelic genetic mutations in the Park2 and PINK1 genes are frequent causes of autosomal recessive PD. Carriers of single heterozygous mutations may manifest subtle signs of disease, thus providing a unique model of preclinical PD. One emerging hypothesis suggests that non-motor symptom of PD, such as cognitive impairment may be due to a distributed functional disruption of...

Effects of Inflammation on Hippocampus and Substantia Nigra Responses to Novelty in Healthy Human Participants

AffiliationsClinical Imaging Sciences Centre, Brighton and Sussex Medical School, University of Sussex Campus, Brighton, UKNeil A Harrison, Mara Cercignani & Hugo D CritchleySackler Centre for Consciousness Science ... • PubMed • Google ScholarSearch for Mara Cercignani in:Nature Research journals • PubMed • Google ScholarSearch for Valerie Voon in:Nature Research journals • PubMed • Google ScholarSearch for Hugo D

Brain Connectomics’ Modification to Clarify Motor and Nonmotor Features of Myotonic Dystrophy Type 1

 Barbara Spanò,1 Mario Torso,1 Chiara Mastropasqua,1 Manlio Giacanelli,4 Carlo Caltagirone,6,7 Mara Cercignani,8 Giovanni Meola,9 and Marco Bozzali1 1Neuroimaging Laboratory, IRCCS Santa Lucia Foundation

Brain Connectomics’ Modification to Clarify Motor and Nonmotor Features of Myotonic Dystrophy Type 1

 Barbara Spanò,1 Mario Torso,1 Chiara Mastropasqua,1 Manlio Giacanelli,4 Carlo Caltagirone,6,7 Mara Cercignani,8 Giovanni Meola,9 and Marco Bozzali1 1Neuroimaging Laboratory, IRCCS Santa Lucia Foundation

A feasibility study exploring the role of pre-operative assessment when examining the mechanism of ‘chemo-brain’ in breast cancer patients

Mara Cercignani Sandra Sacre Neil Harrison Hefina WhiteleyJ‑ones Lisa Mullen Giselle Chamberlain Kevin Davies Charles Zammit Lucy Matthews 0 Helena Harder 0 0 Sussex Health Outcomes Research and

Strategic Lesions in the Anterior Thalamic Radiation and Apathy in Early Alzheimer's Disease

Background Behavioural disorders and psychological symptoms of Dementia (BPSD) are commonly observed in Alzheimer’s disease (AD), and strongly contribute to increasing patients' disability. Using voxel-lesion-symptom mapping (VLSM), we investigated the impact of white matter lesions (WMLs) on the severity of BPSD in patients with amnestic mild cognitive impairment (a-MCI...

“I Know that You Know that I Know”: Neural Substrates Associated with Social Cognition Deficits in DM1 Patients

Myotonic dystrophy type-1 (DM1) is a genetic multi-systemic disorder involving several organs including the brain. Despite the heterogeneity of this condition, some patients with non-congenital DM1 can present with minimal cognitive impairment on formal testing but with severe difficulties in daily-living activities including social interactions. One explanation for this...

fMRI Resting Slow Fluctuations Correlate with the Activity of Fast Cortico-Cortical Physiological Connections

Recording of slow spontaneous fluctuations at rest using functional magnetic resonance imaging (fMRI) allows distinct long-range cortical networks to be identified. The neuronal basis of connectivity as assessed by resting-state fMRI still needs to be fully clarified, considering that these signals are an indirect measure of neuronal activity, reflecting slow local variations in...

Effect of Parasympathetic Stimulation on Brain Activity During Appraisal of Fearful Expressions

Autonomic nervous system activity is an important component of human emotion. Mental processes influence bodily physiology, which in turn feeds back to influence thoughts and feelings. Afferent cardiovascular signals from arterial baroreceptors in the carotid sinuses are processed within the brain and contribute to this two-way communication with the body. These carotid...

Microstructural Damage of the Posterior Corpus Callosum Contributes to the Clinical Severity of Neglect

One theory to account for neglect symptoms in patients with right focal damage invokes a release of inhibition of the right parietal cortex over the left parieto-frontal circuits, by disconnection mechanism. This theory is supported by transcranial magnetic stimulation studies showing the existence of asymmetric inhibitory interactions between the left and right posterior...

Connectivity-Based Parcellation of the Thalamus Explains Specific Cognitive and Behavioural Symptoms in Patients with Bilateral Thalamic Infarct

A novel approach based on diffusion tractography was used here to characterise the cortico-thalamic connectivity in two patients, both presenting with an isolated bilateral infarct in the thalamus, but exhibiting partially different cognitive and behavioural profiles. Both patients (G.P. and R.F.) had a pervasive deficit in episodic memory, but only one of them (R.F.) suffered...

Cognitive Reserve in Granulin-Related Frontotemporal Dementia: from Preclinical to Clinical Stages

ObjectiveConsistent with the cognitive reserve hypothesis, higher education and occupation attainments may help persons with neurodegenerative dementias to better withstand neuropathology before developing cognitive impairment. We tested here the cognitive reserve hypothesis in patients with frontotemporal dementia (FTD), with or without pathogenetic granulin mutations (GRN+ and...

Association between a Genetic Variant of Type-1 Cannabinoid Receptor and Inflammatory Neurodegeneration in Multiple Sclerosis

Genetic ablation of type-1 cannabinoid receptors (CB1Rs) exacerbates the neurodegenerative damage of experimental autoimmune encephalomyelitis, the rodent model of multiple sclerosis (MS). To address the role on CB1Rs in the pathophysiology of human MS, we first investigated the impact of AAT trinucleotide short tandem repeat polymorphism of CNR1 gene on CB1R cell expression, and...