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Comparison of wide field optical coherence tomography angiography with extended field imaging and fluorescein angiography in retinal vascular disorders

the retinal vasculature in more peripheral regions. Supporting information S1 File. Data set. (XLSX) Author Contributions Conceptualization: Marco Pellegrini, Giovanni Staurenghi, Federico Corvi ... . Data curation: Marco Pellegrini, Federico Corvi. Formal analysis: Marco Pellegrini, Mariano Cozzi, Federico Corvi. Funding acquisition: Federico Corvi. Investigation: Marco Pellegrini, Mariano Cozzi

Corneal biomechanical alterations in patients with chronic ocular Graft Versus-Host Disease

represent a possible new surrogate marker of oGVHD severity. Author Contributions Conceptualization: Giuseppe Giannaccare. Data curation: Leonardo Taroni. Formal analysis: Marco Pellegrini. Investigation ... : Marco Pellegrini, Leonardo Taroni, Federico Bernabei, Carlotta Senni, Arianna Grendele. Project administration: Giuseppe Giannaccare. Validation: Vincenzo Scorcia, Emilio C. Campos. Visualization

Corneal endothelium features in Fuchs’ Endothelial Corneal Dystrophy: A preliminary 3D anterior segment optical coherence tomography study

, Pietro Emanuele Napoli. Investigation: Claudio Iovino, Giuseppe Giannaccare, Marco Pellegrini, Mirco Braghiroli, Methodology: Claudio Iovino, Giuseppe Giannaccare, Marco Pellegrini, Mirco Braghiroli ... , Project administration: Claudio Iovino, Pietro Emanuele Napoli. Resources: Claudio Iovino, Giuseppe Giannaccare, Marco Pellegrini, Mirco Braghiroli, Pietro Emanuele Napoli. Software: Pietro Emanuele Napoli

The miRNA Pull Out Assay as a Method to Validate the miR-28-5p Targets Identified in Other Tumor Contexts in Prostate Cancer

,1 Marco Pellegrini,4 and Giuseppe Rainaldi1,2 1Non-coding RNA Laboratory, Institute of Clinical Physiology (IFC), CNR, Via Moruzzi 1, 56124 Pisa, Italy 2Tuscan Tumor Institute (ITT), Via Alderotti 26

Food components and contaminants as (anti)androgenic molecules

Androgens, the main male sex steroids, are the critical factors responsible for the development of the male phenotype during embryogenesis and for the achievement of sexual maturation and puberty. In adulthood, androgens remain essential for the maintenance of male reproductive function and behavior. Androgens, acting through the androgen receptor (AR), regulate male sexual...

Enhanced copy number variants detection from whole-exome sequencing data using EXCAVATOR2

Copy Number Variants (CNVs) are structural rearrangements contributing to phenotypic variation that have been proved to be associated with many disease states. Over the last years, the identification of CNVs from whole-exome sequencing (WES) data has become a common practice for research and clinical purpose and, consequently, the demand for more and more efficient and accurate...

A New Method for Discovering Disease-Specific MiRNA-Target Regulatory Networks

Genes and their expression regulation are among the key factors in the comprehension of the genesis and development of complex diseases. In this context, microRNAs (miRNAs) are post-transcriptional regulators that play an important role in gene expression since they are frequently deregulated in pathologies like cardiovascular disease and cancer. In vitro validation of miRNA...

Xenoestrogens Alter Estrogen Receptor (ER) α Intracellular Levels

Citation: La Rosa P, Pellegrini M, Totta P, Acconcia F, Marino M ( Xenoestrogens Alter Estrogen Receptor (ER) a Intracellular Levels Piergiorgio La Rosa 0 Marco Pellegrini 0 Pierangela Totta 0

Naringenin modulates skeletal muscle differentiation via estrogen receptor α and β signal pathway regulation

Several experiments sustain healthful benefits of the flavanone naringenin (Nar) against chronic diseases including its protective effects against estrogen-related cancers. These experiments encourage Nar use in replacing estrogen treatment in post-menopausal women avoiding the serious side effects ascribed to this hormone. However, at the present, scarce data are available on...

The Role of Natriuretic Peptides for the Diagnosis of Left Ventricular Dysfunction

Natriuretic peptides (NPs) are entered in current guidelines for heart failure (HF) diagnosis and management because of their high specificity and sensibility in screening patients with acute dyspnea. Due to their availability and relatively low cost, they became the first step examinations in HF patients evaluation at hospital admission together with clinical and chest...

MicroRNA 19a replacement partially rescues fin and cardiac defects in zebrafish model of Holt Oram syndrome

Marco Pellegrini in:Nature Research journals • PubMed • Google ScholarSearch for Alessandro Cellerino in:Nature Research journals • PubMed • Google ScholarSearch for Federico Cremisi in:Nature Research

The role of erythropoietin stimulating agents in anemic patients with heart failure: solved and unresolved questions

The role of erythropoietin stimulating agents in anemic patients with heart failure: solved and unresolved questions Alberto Palazzuoli, Gaetano Ruocco, Marco Pellegrini, Carmelo De Gori, Gabriele

Tandem repeats discovery service (TReaDS) applied to finding novel cis-acting factors in repeat expansion diseases

Background Tandem repeats are multiple duplications of substrings in the DNA that occur contiguously, or at a short distance, and may involve some mutations (such as substitutions, insertions, and deletions). Tandem repeats have been extensively studied also for their association with the class of repeat expansion diseases (mostly affecting the nervous system). Comparative...

Ab initio detection of fuzzy amino acid tandem repeats in protein sequences

Background Tandem repetitions within protein amino acid sequences often correspond to regular secondary structures and form multi-repeat 3D assemblies of varied size and function. Developing internal repetitions is one of the evolutionary mechanisms that proteins employ to adapt their structure and function under evolutionary pressure. While there is keen interest in...

A knowledge base for the discovery of function, diagnostic potential and drug effects on cellular and extracellular miRNAs

Bonnici Alessandro Laganà Giuseppe Rainaldi Marco Pellegrini Alfredo Pulvirenti 0 Rosalba Giugno 0 Alfredo Ferro 0 0 Department of Clinical and Molecular Biomedicine - University of Catania , Italy

Continuous versus bolus intermittent loop diuretic infusion in acutely decompensated heart failure: a prospective randomized trial

Introduction Intravenous loop diuretics are a cornerstone of therapy in acutely decompensated heart failure (ADHF). We sought to determine if there are any differences in clinical outcomes between intravenous bolus and continuous infusion of loop diuretics. Methods Subjects with ADHF within 12 hours of hospital admission were randomly assigned to continuous infusion or twice...

TRStalker: an efficient heuristic for finding fuzzy tandem repeats

Motivation: Genomes in higher eukaryotic organisms contain a substantial amount of repeated sequences. Tandem Repeats (TRs) constitute a large class of repetitive sequences that are originated via phenomena such as replication slippage and are characterized by close spatial contiguity. They play an important role in several molecular regulatory mechanisms, and also in several...

AMIC@: All MIcroarray Clusterings @ once

The AMIC@ Web Server offers a light-weight multi-method clustering engine for microarray gene-expression data. AMIC@ is a highly interactive tool that stresses user-friendliness and robustness by adopting AJAX technology, thus allowing an effective interleaved execution of different clustering algorithms and inspection of results. Among the salient features AMIC@ offers, there...