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Robustness of biomarker determination in breast cancer by RT-qPCR: impact of tumor cell content, DCIS and non-neoplastic breast tissue

Tissue heterogeneity in formalin-fixed paraffin-embedded (FFPE) breast cancer specimens may affect the accuracy of reverse transcription quantitative real-time PCR (RT-qPCR). Herein, we tested the impact of tissue heterogeneity of breast cancer specimen on the RT-qPCR-based gene expression assay MammaTyper®. MammaTyper® quantifies the mRNA expression of the four biomarkers ERBB2...

Charcoal kiln sites, associated landscape attributes and historic forest conditions: DTM-based investigations in Hesse (Germany)

BackgroundAn examination of the distribution of ancient charcoal kiln sites in the forest landscape seems to be worthwhile, since general trends in the selection of suitable kiln site locations in the past might become obvious. In this way forest landscape elements with a more intense usage by charcoal burning can be identified. By doing this, we can expect to gain information on...

Chiral magnetoresistance in the Weyl semimetal NbP

Schmidt Claudia Felser BinghaiYan Kornelius Nielsch OPEN NbP is a recently realized Weyl semimetal (WSM), hosting Weyl points through which conduction and valence bands cross linearly in the bulk and

Epsin Family Member 3 and Ribosome-Related Genes Are Associated with Late Metastasis in Estrogen Receptor-Positive Breast Cancer and Long-Term Survival in Non-Small Cell Lung Cancer Using a Genome-Wide Identification and Validation Strategy

Background In breast cancer, gene signatures that predict the risk of metastasis after surgical tumor resection are mainly indicative of early events. The purpose of this study was to identify genes linked to metastatic recurrence more than three years after surgery. Methods Affymetrix HG U133A and Plus 2.0 array datasets with information on metastasis-free, disease-free or...

GLUT-1 expression is largely unrelated to both hypoxia and the Warburg phenotype in squamous cell carcinomas of the vulva

Background Strongly increased uptake of glucose is a hallmark of solid malignant tumors. This phenotype can be triggered by hypoxia-induced gene expression changes or can occur independently of hypoxia as a consequence of malignant transformation itself, and is often referred to as the Warburg effect. The glycolytic phenotype has been associated with malignant progression and...

Identification of sample annotation errors in gene expression datasets

The comprehensive transcriptomic analysis of clinically annotated human tissue has found widespread use in oncology, cell biology, immunology, and toxicology. In cancer research, microarray-based gene expression profiling has successfully been applied to subclassify disease entities, predict therapy response, and identify cellular mechanisms. Public accessibility of raw data...

Application of computational fluid dynamics on cavitation in journal bearings

Journal bearings are applied in internal combustion engines due to their favourable wearing quality and operating characteristics. Under certain operating conditions damage of the journal bearing can occur caused by cavitation. The cavitation reduces the load capacity and leads to material erosion. Experimental investigations of cavitating flows in dimension of real journal...

Investigation of the velocity distribution in the flow of a journal bearing model

In many previous studies the main focus was put on the pressure distribution in the lubricating gap. Due to the limited space in the gap an investigation of the velocity distribution is very difficult or rather impossible. Based on the geometrical shapes of a real journal bearing, a bearing model test rig with an increased relative gap width has been developed. Thus, it is...

Efficacy and safety of palbociclib in combination with letrozole as first-line treatment of ER-positive, HER2-negative, advanced breast cancer: expanded analyses of subgroups from the randomized pivotal trial PALOMA-1/TRIO-18

Background Palbociclib is an oral small-molecule inhibitor of cyclin-dependent kinases 4 and 6. In the randomized, open-label, phase II PALOMA-1/TRIO-18 trial, palbociclib in combination with letrozole improved progression-free survival (PFS) compared with letrozole alone as first-line treatment of estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2...

NCOA3 is a selective co-activator of estrogen receptor α-mediated transactivation of PLAC1 in MCF-7 breast cancer cells

Background The placenta-specific 1 (PLAC1) gene encodes a membrane-associated protein which is selectively expressed in the placental syncytiotrophoblast and in murine fetal tissues during embryonic development. In contrast to its transcriptional repression in all other adult normal tissues, PLAC1 is frequently activated and highly expressed in a variety of human cancers, in...

Experimental research of the couette flow with cross flow

When a solid cylinder is rotating inside a hollow cylinder, a characteristic fluid flow occurs inside the gap between the two cylinders, caused by the adhesion of the fluid at the walls. This flow problem is widely known as the Couette-flow. If an additional flow entrances through a radial located feedhole at the outer hollow cylinder, there is an interaction between the cross...

Prognostic influence of cyclooxygenase-2 protein and mRNA expression in node-negative breast cancer patients

authors read and approved the final manuscript. Authors information Marcus Schmidt and Jan. G. Hengstler are shared senior authors.

Negative magnetoresistance without well-defined chirality in the Weyl semimetal TaP

, Marcel Naumann, Mukkattu O. Ajeesh, Marcus Schmidt, Michael Baenitz, Dmitry Sokolov, Horst Borrmann, Michael Nicklas, Claudia Felser, Elena Hassinger & Binghai YanMax Planck Institute for the Physics of ... Research journals • PubMed • Google ScholarSearch for Mukkattu O. Ajeesh in:Nature Research journals • PubMed • Google ScholarSearch for Marcus Schmidt in:Nature Research journals • PubMed • Google

A randomized phase III study evaluating pegylated liposomal doxorubicin versus capecitabine as first-line therapy for metastatic breast cancer: results of the PELICAN study

Purpose The PELICAN trial evaluates for the first time efficacy and safety of pegylated liposomal doxorubicin (PLD) versus capecitabine as first-line treatment of metastatic breast cancer (MBC). Methods This randomized, phase III, open-label, multicenter trial enrolled first-line MBC patients who were ineligible for endocrine or trastuzumab therapy. Cumulative adjuvant...

Survival models with preclustered gene groups as covariates

Kai Kammers 0 Michel Lang 0 Jan G Hengstler Marcus Schmidt Jrg Rahnenfhrer 0 0 Department of Statistics, TU Dortmund University , Dortmund , Germany Background: An important application of high

Prognostic Influence of Pre-Operative C-Reactive Protein in Node-Negative Breast Cancer Patients

The importance of inflammation is increasingly noticed in cancer. The aim of this study was to analyze the prognostic influence of pre-operative serum C-reactive protein (CRP) in a cohort of 148 lymph node-negative breast cancer patients. The prognostic significance of CRP level for disease-free survival (DFS), metastasis-free survival (MFS) and overall survival (OS) was...

Disrupted Functional Brain Connectivity during Verbal Working Memory in Children and Adolescents with Schizophrenia

Children and adolescents who develop schizophrenia tend to have greater symptom severity than adults who develop the illness. Since the brain continues to mature into early adulthood, developmental differences in brain structure and function may provide clues to the underlying neurobiology of schizophrenia. With an emerging body of evidence supporting disrupted connectivity...

Tumor architecture exerts no bias on nuclear grading in breast cancer diagnosis

We recently reported that nuclear grading in prostate cancer is subject to a strong confirmation bias induced by the tumor architecture. We now wondered whether a similar bias governs nuclear grading in breast carcinoma. An unannounced test was performed at a pathology conference. Pathologists were asked to grade nuclei in a PowerPoint presentation. Circular high power fields of...

Comparison of scores for bimodality of gene expression distributions and genome-wide evaluation of the prognostic relevance of high-scoring genes

Background A major goal of the analysis of high-dimensional RNA expression data from tumor tissue is to identify prognostic signatures for discriminating patient subgroups. For this purpose genome-wide identification of bimodally expressed genes from gene array data is relevant because distinguishability of high and low expression groups is easier compared to genes with unimodal...