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Search: authors:"Maren Wehrs"

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Production efficiency of the bacterial non-ribosomal peptide indigoidine relies on the respiratory metabolic state in S. cerevisiae

Beyond pathway engineering, the metabolic state of the production host is critical in maintaining the efficiency of cellular production. The biotechnologically important yeast Saccharomyces cerevisiae adjusts its energy metabolism based on the availability of oxygen and carbon sources. This transition between respiratory and non-respiratory metabolic state is accompanied by...

Isolation and characterization of novel mutations in the pSC101 origin that increase copy number

, Emeryville, CA, 94608, USAMitchell G. Thompson, Nima Sedaghatian, Maren Wehrs, Constance B. Bailey, Nurgul Kaplan, Nathan J. Hillson, Aindrila Mukhopadhyay & Jay D. KeaslingBiological Systems & Engineering ... Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USAMitchell G. Thompson, Nima Sedaghatian, Jesus F. Barajas, Maren Wehrs, Constance B. Bailey, Nurgul Kaplan, Nathan J. Hillson, Aindrila

A Cas9-based toolkit to program gene expression in Saccharomyces cerevisiae

Despite the extensive use of Saccharomyces cerevisiae as a platform for synthetic biology, strain engineering remains slow and laborious. Here, we employ CRISPR/Cas9 technology to build a cloning-free toolkit that addresses commonly encountered obstacles in metabolic engineering, including chromosomal integration locus and promoter selection, as well as protein localization and...