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Correction to: The Italian multiple sclerosis register Unfortunately in the original publication, the affiliation of the author Maria Pia Amato was incorrect. The author inadvertently missed out to include her ... second affiliation. The correct affiliation for Maria Pia Amato should read as follows: 3Department NEUROFARBA, MS Center AOU Careggi, University of Florence, Florence, Italy 4IRCCS Fondazione Don Carlo

Correction to: Management of pregnancy-related issues in multiple sclerosis patients: the need for an interdisciplinary approach

, Italy 3 Gynecology and Obstetrics Department, Hospital Papa Giovanni XXIII , Bergamo , Italy 4 Department of Neurology, INSPE, San Raffaele Scientific Institute , Milan , Italy 5 Maria Pia Amato 6

Efficacy of fingolimod and interferon beta-1b on cognitive, MRI, and clinical outcomes in relapsing–remitting multiple sclerosis: an 18-month, open-label, rater-blinded, randomised, multicentre study (the GOLDEN study)

) Antonio Uccelli, Department of Neurosciences Ophthalmology and Genetics, University of Genoa, Genoa, Italy, (18) Maria Pia Amato, Department NEUROFARBA, University of Florence, Florence, Italy, (19

Less Frequent and Less Severe Flu-Like Syndrome in Interferon Beta-1a Treated Multiple Sclerosis Patients with at Least One Allele Bearing the G>C Polymorphism at Position -174 of the IL-6 Promoter Gene

One of the most common adverse event of interferon beta (IFNβ) therapy for multiple sclerosis is flu-like syndrome (FLS), which has been reportedly related to increased levels of cytokines such as interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-α). Average cytokine levels can be affected by single nucleotide polymorphism in the gene promoter regions. To investigate...

The Use of Immunosuppressant Therapy for Multiple Sclerosis in Italy: A Multicenter Retroprospective Study

in our population. Novartis, Bayer-Schering and receives speaker honoraria from Biogen Idec, Merck Serono, Novartis, Almirall, Bayer-Schering and Genzyme. Prof. Maria Pia Amato serves on scientific

Subcutaneous Interferon β-1a May Protect against Cognitive Impairment in Patients with Relapsing–Remitting Multiple Sclerosis: 5-Year Follow-up of the COGIMUS Study

. Vicenzo Brescia Morra has received travel grants from Bayer Schering, Biogen Dompe, Merck Serono, Novartis and Sanofi-Aventis. Maria Pia Amato had received personal compensation and research grants from

MxA mRNA Quantification and Disability Progression in Interferon Beta-Treated Multiple Sclerosis Patients

-Serono, TEVA. Luisa Imberti: received support to cover travel expenses and participation to congresses from Biogen-Idec, Merck-Serono, TEVA, and grants from Biogen-Idec and Merck-Serono. Maria Pia Amato

Relevance of Brain Lesion Location to Cognition in Relapsing Multiple Sclerosis

Objective To assess the relationship between cognition and brain white matter (WM) lesion distribution and frequency in patients with relapsing-remitting multiple sclerosis (RR MS). Methods MRI-based T2 lesion probability map (LPM) was used to assess the relevance of brain lesion location for cognitive impairment in a group of 142 consecutive patients with RRMS. Significance of...

Impact of Natalizumab on Cognitive Performances and Fatigue in Relapsing Multiple Sclerosis: A Prospective, Open-Label, Two Years Observational Study

Background and Objectives Natalizumab reduces the relapse rate and magnetic resonance imaging activity in patients with Relapsing-Remitting Multiple Sclerosis (RRMS). So far the influence of natalizumab on cognitive functions and fatigue in MS remains uncertain. The aim of this prospective, open-label, observational study was to evaluate the possible effects of natalizumab on...

Brief International Cognitive Assessment for MS (BICAMS): international standards for validation

An international expert consensus committee recently recommended a brief battery of tests for cognitive evaluation in multiple sclerosis. The Brief International Cognitive Assessment for MS (BICAMS) battery includes tests of mental processing speed and memory. Recognizing that resources for validation will vary internationally, the committee identified validation priorities, to...

Improving the Characterization of Radiologically Isolated Syndrome Suggestive of Multiple Sclerosis

Objective To improve the characterization of asymptomatic subjects with brain magnetic resonance imaging (MRI) abnormalities highly suggestive of multiple sclerosis (MS), a condition named as “radiologically isolated syndrome” (RIS). Methods Quantitative MRI metrics such as brain volumes and magnetization transfer (MT) were assessed in 19 subjects previously classified as RIS, 20...

Male Sex Is Independently Associated with Faster Disability Accumulation in Relapse-Onset MS but Not in Primary Progressive MS

Background Multiple Sclerosis is more common in women than men and females have more relapses than men. In a large international cohort we have evaluated the effect of gender on disability accumulation and disease progression to determine if male MS patients have a worse clinical outcome than females. Methods Using the MSBase Registry, data from 15,826 MS patients from 25...

Radiologically Isolated Syndrome: 5-Year Risk for an Initial Clinical Event

Objective To report the 5-year risk and to identify risk factors for the development of a seminal acute or progressive clinical event in a multi-national cohort of asymptomatic subjects meeting 2009 RIS Criteria. Methods Retrospectively identified RIS subjects from 22 databases within 5 countries were evaluated. Time to the first clinical event related to demyelination (acute or...

Epidural analgesia and cesarean delivery in multiple sclerosis post-partum relapses: the Italian cohort study

Vittorio Martinelli 10 Giancarlo Comi 10 Maria Pia Amato 0 for the MS Study Group of the Italian Neurological Society 0 Department of Neurology, University of Florence , Viale Morgagni 85, 50134, Florence

Geographical Variations in Sex Ratio Trends over Time in Multiple Sclerosis

Background A female/male (F/M) ratio increase over time in multiple sclerosis (MS) patients was demonstrated in many countries around the world. So far, a direct comparison of sex ratio time-trends among MS populations from different geographical areas was not carried out. Objective In this paper we assessed and compared sex ratio trends, over a 60-year span, in MS populations...

Immunoproteasome LMP2 60HH Variant Alters MBP Epitope Generation and Reduces the Risk to Develop Multiple Sclerosis in Italian Female Population

Background Albeit several studies pointed out the pivotal role that CD4+T cells have in Multiple Sclerosis, the CD8+ T cells involvement in the pathology is still in its early phases of investigation. Proteasome degradation is the key step in the production of MHC class I-restricted epitopes and therefore its activity could be an important element in the activation and regulation...

Persistence on Therapy and Propensity Matched Outcome Comparison of Two Subcutaneous Interferon Beta 1a Dosages for Multiple Sclerosis

Objectives To compare treatment persistence between two dosages of interferon β-1a in a large observational multiple sclerosis registry and assess disease outcomes of first line MS treatment at these dosages using propensity scoring to adjust for baseline imbalance in disease characteristics. Methods Treatment discontinuations were evaluated in all patients within the MSBase...