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77 papers found.
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T cell receptor repertoire among women who cleared and failed to clear cervical human papillomavirus infection: An exploratory proof-of-principle study

Kuhs, Shih-Wen Lin, Xing Hua, Mark Schiffman, Robert D. Burk, Ana Cecilia Rodriguez, Rolando Herrero, Christian C. Abnet, Neal D. Freedman, Ligia A. Pinto, David Hamm, Harlan Robins, Allan Hildesheim ... , Jianxin Shi, Mahboobeh Data curation: Xing Hua, Mark Schiffman, Ana Cecilia Rodriguez, Rolando Herrero, David Formal analysis: Xing Hua, David Hamm, Jianxin Shi. Funding acquisition: Mahboobeh Safaeian

No Evidence for Synergy Between Human Papillomavirus Genotypes for the Risk of High-Grade Squamous Intraepithelial Lesions in a Large Population-Based Study

for Disease Control and Prevention; Jane McGrath, MD, University of New Mexico Health Sciences Center; Steven Jenison, MD, community member; Mark Schiffman, MD, MPH, National Cancer Institute; Philip

A prospective study of absolute risk and determinants of human papillomavirus incidence among young women in Costa Rica

), Mark Schiffman (Medical Monitor and NCI Co-project Officer), John T. Schiller (HPV Virologist), Mark Sherman (Quality Control Pathologist), Diane Solomon (Medical Monitor and Quality Control Pathologist

Seroprevalence of 8 Oncogenic Human Papillomavirus Genotypes and Acquired Immunity Against Reinfection

Background. Natural human papillomavirus (HPV) antibody titers have shown protection against subsequent HPV infection, but previous studies were restricted to few HPV genotypes. We examined the association of naturally occurring antibodies against 8 carcinogenic HPV types with subsequent infections. Methods. A total of 2302 women enrolled in the Atypical Squamous Cells of...

An Updated Natural History Model of Cervical Cancer: Derivation of Model Parameters

Genetics, National Cancer Institute, Bethesda, Maryland (Mark Schiffman, Alan Hildesheim); Proyecto Epidemiológica Guanacaste, Fundación INCIENSA, San José, Costa Rica (Ana Cecilia Rodriguez, Rolando Herrero

Performance of Self-Collected Cervical Samples in Screening for Future Precancer Using Human Papillomavirus DNA Testing

Epidemiológico Guanacaste , Fundación INCIENSA, San José, Costa Rica (CP, PG 2 Carolina Porras , Allan Hildesheim, Paula González, Mark Schiffman 3 The Author 2014. Published by Oxford University Press. All ... coordinator), Mark Schiffman (medical monitor and NCI co-project officer), John T. Schiller (HPV virologist), Mark Sherman (QC pathologist), Diane Solomon (medical monitor and QC pathologist), Sholom Wacholder

Reassurance Against Future Risk of Precancer and Cancer Conferred by a Negative Human Papillomavirus Test

Primary human papillomavirus (HPV) testing (without concurrent Pap tests) every 3 years is under consideration in the United States as an alternative to the two recommended cervical cancer screening strategies: primary Pap testing every 3 years, or concurrent Pap and HPV testing (“cotesting”) every 5 years. Using logistic regression and Weibull survival models, we estimated and...

Response: Re: Human Papillomavirus Testing in the Prevention of Cervical Cancer

limited, and the opportunities for benefit so great that all earnest approaches must be welcomed. MARK SCHIFFMAN NICOLAS WENTZENSEN SHOLOM WACHOLDER WALTER KINNEY JULIA C. GAGE PHILIP E. CASTLE

Impact of Human Papillomavirus Vaccination on Cervical Cytology Screening, Colposcopy, and Treatment

of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland (Diane Solomon, Allan Hildesheim, Sholom Wacholder, Mark Schiffman); and Prevention and Implementation Group ... , Maryland—Allan Hildesheim (coPrincipal Investigator and NCI co-Project Officer), Aimée R. Kreimer (investigator), Douglas R. Lowy (HPV virologist), Nora Macklin (trial coordinator), Mark Schiffman (medical

Evolution and Taxonomic Classification of Alphapapillomavirus 7 Complete Genomes: HPV18, HPV39, HPV45, HPV59, HPV68 and HPV70

BackgroundThe species Alphapapillomavirus 7 (alpha-7) contains human papillomavirus genotypes that account for 15% of invasive cervical cancers and are disproportionately associated with adenocarcinoma of the cervix. Complete genome analyses enable identification and nomenclature of variant lineages and sublineages. MethodsThe URR/E6 region was sequenced to screen for novel...

Human Papillomavirus Testing in the Prevention of Cervical Cancer

Mark Schiffman Nicolas Wentzensen Sholom Wacholder Walter Kinney Julia C. Gage Philip E. Castle Strong evidence now supports the adoption of cervical cancer prevention strategies that explicitly

A large, population-based study of age-related associations between vaginal pH and human papillomavirus infection

Background Vaginal pH is related to genital tract inflammation and changes in the bacterial flora, both suggested cofactors for persistence of human papillomavirus (HPV) infection. To evaluate the relationship between vaginal pH and HPV, we analyzed data from our large population-based study in Guanacaste, Costa Rica. We examined vaginal pH and the risk of HPV infection...

Longitudinal Analysis of Carcinogenic Human Papillomavirus Infection and Associated Cytologic Abnormalities in the Guanacaste Natural History Study: Looking Ahead to Cotesting

Background. Few studies have addressed the timing of cervical cytologic abnormalities and human papillomavirus (HPV) positivity during the course of an infection. It remains largely unknown how infections detected by HPV and cytology wax and wane relative to each other. The aim of this analysis was to assess the longitudinal relationship of abnormal cytology and HPV positivity in...

Clustering of Multiple Human Papillomavirus Infections in Women From a Population-Based Study in Guanacaste, Costa Rica

Objective. To evaluate clustering patterns of prevalent infection with multiple human papillomavirus (HPV) types in 8365 nonhysterectomized women from the Guanacaste Study of HPV Natural History. Methods. HPV testing was performed on cervical cells by MY09/M11 L1 degenerate consensus primer polymerase chain reaction method, with dot-blot hybridization for genotyping. Logistic...

Impact of Improved Classification on the Association of Human Papillomavirus With Cervical Precancer

: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health , Bethesda, Maryland (Philip E. Castle, Mark Schiffman, Nicolas Wentzensen); Departments of Molec- ular

RESPONSE: Re: Have We Resolved How To Triage Equivocal Cervical Cytology?

, we favor meta-analyses that begin by including only viable testing options, regardless of worthy characteristics of the older published studies. DIANE SOLOMON MARK SCHIFFMAN (2) Sherman ME, Cox JT

Reduced Prevalence of Vulvar HPV16/18 Infection Among Women Who Received the HPV16/18 Bivalent Vaccine: A Nested Analysis Within the Costa Rica Vaccine Trial

), Nora Macklin (trial coordinator), Mark Schiffman (medical monitor and NCI co-project officer), John T. Schiller (HPV virologist), Mark Sherman (QC pathologist), Diane Solomon (medical monitor and QC ... Kuhs, Mark Schiffman, Douglas Lowy, Mahboobeh Safaeian, John Schiller, Sholom Wacholder, Allan Hildesheim, and Aimée R. Kreimer: GlaxoSmithKline Biologicals (GSK) provided vaccine and support for aspects

Methylation of Human Papillomavirus Type 16 Genome and Risk of Cervical Precancer in a Costa Rican Population

Background Previous studies have suggested an association between human papillomavirus type 16 (HPV16) genome methylation and cervical intraepithelial neoplasia grade 3 (CIN3) (ie, cervical precancer) and cancer, but the results have been inconsistent.

The Cervical Microbiome over 7 Years and a Comparison of Methodologies for Its Characterization

Background The rapidly expanding field of microbiome studies offers investigators a large choice of methods for each step in the process of determining the microorganisms in a sample. The human cervicovaginal microbiome affects female reproductive health, susceptibility to and natural history of many sexually transmitted infections, including human papillomavirus (HPV). At...