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Teachers Are Making a Difference: Understanding the Influence of Favorite Teachers

of Favorite Teachers Mark A. Smith and Karen Schmidt University of Northern Colorado, Greeley, CO, USA Using the theoretical framework of occupational socialization, the purpose of this study was to ... . In W. R. Houston, M. Haberman , J. P. Sikula , & Association of Teacher Educators (Eds.), Handbook of research on teacher education (pp. 329 - 348 ). New York, NY: Macmillan. Dr. Mark A. Smith is an

The actin regulator zyxin reinforces airway smooth muscle and accumulates in airways of fatal asthmatics

Bronchospasm induced in non-asthmatic human subjects can be easily reversed by a deep inspiration (DI) whereas bronchospasm that occurs spontaneously in asthmatic subjects cannot. This physiological effect of a DI has been attributed to the manner in which a DI causes airway smooth muscle (ASM) cells to stretch, but underlying molecular mechanisms–and their failure in asthma...

Antimicrobial peptide β-defensin-1 expression is upregulated in Alzheimer’s brain

Mark A Smith 0 Xiongwei Zhu 0 0 Department of Pathology, School of Medicine, Case Western Reserve University , 10900 Euclid Ave., Cleveland, OH 44106 , USA 1 Department of Biological Sciences, School of

Ricin Crosses Polarized Human Intestinal Cells and Intestines of Ricin-Gavaged Mice without Evident Damage and Then Disseminates to Mouse Kidneys

Ricin is a potent toxin found in the beans of Ricinus communis and is often lethal for animals and humans when aerosolized or injected and causes significant morbidity and occasional death when ingested. Ricin has been proposed as a bioweapon because of its lethal properties, environmental stability, and accessibility. In oral intoxication, the process by which the toxin transits...

LIM Domains Target Actin Regulators Paxillin and Zyxin to Sites of Stress Fiber Strain

Contractile actomyosin stress fibers are critical for maintaining the force balance between the interior of the cell and its environment. Consequently, the actin cytoskeleton undergoes dynamic mechanical loading. This results in spontaneous, stochastic, highly localized strain events, characterized by thinning and elongation within a discrete region of stress fiber. Previous work...

Dedicated Industrial Oilseed Crops as Metabolic Engineering Platforms for Sustainable Industrial Feedstock Production

• Google ScholarSearch for Mark A. Smith in:Nature Research journals • PubMed • Google ScholarSearch for Xueyuan Li in:Nature Research journals • PubMed • Google ScholarSearch for Weicong Qi in:Nature

Modeling the heterogeneity in risk of progression to Alzheimer's disease acrosscognitive profiles in mild cognitive impairment

IntroductionHeterogeneity in risk of conversion to Alzheimer's disease (AD) among individualswith mild cognitive impairment (MCI) is well known. Novel statistical methods thatare based on partially ordered set (poset) models can be used to create modelsthat provide detailed and accurate information about performance with specificcognitive functions. This approach allows for the...

Early Induction of Oxidative Stress in Mouse Model of Alzheimer Disease with Reduced Mitochondrial Superoxide Dismutase Activity

the progression of AD. We thank Dr. Lennart Mucke for providing us the brain tissues from the hAPP/Sod2 mice. Professor Mark A. Smith, co-author of this manuscript, passed away on December 19, 2010. His

A Novel Endogenous Indole Protects Rodent Mitochondria and Extends Rotifer Lifespan

Aging is a multi-factorial process, however, it is generally accepted that reactive oxygen species (ROS) are significant contributors. Mitochondria are important players in the aging process because they produce most of the cellular ROS. Despite the strength of the free-radical hypothesis, the use of free radical scavengers to delay aging has generated mixed results in vertebrate...

Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death

In Alzheimer disease (AD), amyloid-β (Aβ) oligomer is suggested to play a critical role in imitating neurodegeneration, although its pathogenic mechanism remains to be determined. Recently, the cellular prion protein (PrPC) has been reported to be an essential co-factor in mediating the neurotoxic effect of Aβ oligomer. However, these previous studies focused on the synaptic...

Dysregulated LRRK2 Signaling in Response to Endoplasmic Reticulum Stress Leads to Dopaminergic Neuron Degeneration in C. elegans

Mutation of leucine-rich repeat kinase 2 (LRRK2) is the leading genetic cause of Parkinson's Disease (PD), manifested as age-dependent dopaminergic neurodegeneration, but the underlying molecular mechanisms remain unclear. Multiple roles of LRRK2 may contribute to dopaminergic neurodegeneration. Endoplasmic reticulum (ER) stress has also been linked to PD pathogenesis, but its...

Pathogenesis of lassa fever in cynomolgus macaques

Lisa E Hensley Mark A Smith Joan B Geisbert 0 Elizabeth A Fritz 0 Kathleen M Daddario-DiCaprio Tom Larsen Thomas W Geisbert 0 0 Galveston National Laboratory, University of Texas Medical Branch

Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels: Implication in the pathogenesis of Alzheimer’s disease

Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels: Implication in the pathogenesis of Alzheimer’s disease Gjumrakch Aliev1, Eldar Gasimov2, Mark E Obrenovich3, Kathryn Fischbach1, Justin C Shenk1, Mark A Smith3, George Perry3,41Department of Biology and 4College of Sciences, University of Texas at San Antonio, San Antonio, Texas, USA; 2Department of...

A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules

The phosphorylated ribosomal protein S6 (pS6) is associated with the 40S ribosomal subunit in eukaryotes and is thought to have a role in RNA storage, degradation, and re-entry into translation. In this study, we found pS6 localized to granulovacuolar degeneration (GVD) within the pyramidal neurons. Immunohistochemical analysis found that nearly 20-fold more neurons contain pS6...

Expression of CD74 is increased in neurofibrillary tangles in Alzheimer's disease

Alzheimer disease (AD) is a chronic neurodegenerative disease that is characterized by progressive memory loss. Pathological markers of AD include neurofibrillary tangles, accumulation of amyloid-β plaques, neuronal loss, and inflammation. The exact events that lead to the neuronal dysfunction and loss are not completely understood. However, pro-inflammatory cytokines, such as...

Organic environments on Saturn’s moon, Titan: Simulating chemical reactions and analyzing products by FT-ICR and ion-trap mass spectrometry

Laboratory simulations have been carried out to model chemical reactions that possibly take place in the stratosphere of Saturn’s moon, Titan. The aerosol products of these reactions (tholin samples) have been systematically analyzed by mass spectrometry using electrospray ionization (ESI) and laser desorption (LD). A wide variety of ions with a general formula CxHyNz detected by...

Neuroprotective effect of cocoa flavonoids on in vitro oxidative stress

When we published the article“Ramiro-Puig E et al (2008) Neuroprotective effect of cocoa flavonoids on in vitro oxidative stress. Eur J Nutr (publication online first)” [The online version of the article can be found at http://dx.doi.org/10.1007/s00394-008-0761-4]on 29 November 2008, a typo in the title remained unnoticed. The correct title should read:Neuroprotective effect of...