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Association between urinary free light chains and progression to end stage renal disease in chronic kidney disease

research fellowship. Author Contributions Conceptualization: Iain Chapple, Indranil Dasgupta, Stephen J. Harding, Charles J. Ferro, Paul Cockwell. Data curation: Anthony Fenton, Mark D. Jesky, Rachel ... . Ferro, Paul Cockwell. Investigation: Anthony Fenton, Mark D. Jesky, Rachel Webster, Stephanie J. Stringer, Indranil Dasgupta, Stephen J. Harding, Charles J. Ferro, Paul Cockwell. Methodology: Anthony

Serum endotrophin, a type VI collagen cleavage product, is associated with increased mortality in chronic kidney disease

Background Patients with chronic kidney disease (CKD) are at increased risk of end-stage renal disease (ESRD) and early mortality. The underlying pathophysiological processes are not entirely understood but may include dysregulation of extracellular matrix formation with accelerated systemic and renal fibrosis. We assessed the relationship between endotrophin (ETP), a marker of...

Humoral immunity to memory antigens and pathogens is maintained in patients with chronic kidney disease

curation: Nadezhda A. Wall, C. Coral Dominguez-Medina, Sian E. Faustini, Charlotte N. Cook, Andrew McClean, Mark D. Jesky, Charles J. Ferro, Paul Cockwell. Formal analysis: Nadezhda A. Wall. Investigation ... . Resources: Andrew McClean, Mark D. Jesky. Supervision: C. Coral Dominguez-Medina, Lorraine Harper, Adam F. Cunningham. Validation: Marisol Perez-Toledo. Writing ? original draft: Nadezhda A. Wall, Lorraine

Health-Related Quality of Life Impacts Mortality but Not Progression to End-Stage Renal Disease in Pre-Dialysis Chronic Kidney Disease: A Prospective Observational Study

Background Chronic kidney disease (CKD) is associated with reduced health-related quality of life (HRQL). However, the relationship between pre-dialysis CKD, HRQL and clinical outcomes, including mortality and progression to end-stage renal disease (ESRD) is unclear. Methods All 745 participants recruited into the Renal Impairment In Secondary Care study to end March 2014 were...

Allopurinol Is an Independent Determinant of Improved Arterial Stiffness in Chronic Kidney Disease: A Cross-Sectional Study

Background Arterial stiffness is increased in patients with CKD and is a powerful predictor of cardiovascular morbidity and mortality. Use of the xanthine oxidase inhibitor allopurinol has been shown to improve endothelial function, reduce left ventricular hypertrophy and possibly improve cardiovascular outcome. We explored the relationship between use of allopurinol and arterial...