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PCORnet’s Collaborative Research Groups

PCORnet's Collaborative Research Groups Mark J Pletcher,1,2 Christopher B Forrest,3 Thomas W Carton4 1Department of Epidemiology and Biostatistics, University of California, San Francisco, CA

Cigarette and e-cigarette dual use and risk of cardiopulmonary symptoms in the Health eHeart Study

Conceptualization: Julie B. Wang, Gregory M. Marcus. Formal analysis: Julie B. Wang, Gregory Nah, Eric Vittinghoff, Mark J. Pletcher, Gregory M. Marcus. Funding acquisition: Julie B. Wang, Jeffrey E. Olgin, Mark J ... . Pletcher, Gregory M. Marcus. Investigation: Julie B. Wang, Gregory M. Marcus. Methodology: Julie B. Wang, Eric Vittinghoff, Mark J. Pletcher, Gregory M. Marcus. Resources: Julie B. Wang, Jeffrey E. Olgin

Trends in rate of acute myocardial infarction among patients aged <30 years

the School of Medicine, Johns Hopkins University , 720 Rutland Avenue, Baltimore, Maryland , USA 2 Xiaofan Guo, Eric Vittinghoff, and Mark J. Pletcher are at the Department of Epidemiology and

Volunteer Participation in the Health eHeart Study: A Comparison with the US Population

Direct volunteer “eCohort” recruitment can be an efficient way of recruiting large numbers of participants, but there is potential for volunteer bias. We compared self-selected participants in the Health eHeart Study to participants in the National Health And Nutrition Examination Survey (NHANES) 2013–14, a cross-sectional survey of the US population. Compared with the US...

Young Adult Exposure to Cardiovascular Risk Factors and Risk of Events Later in Life: The Framingham Offspring Study

Background It is unclear whether coronary heart disease (CHD) risk factor exposure during early adulthood contributes to CHD risk later in life. Our objective was to analyze whether extent of early adult exposures to systolic and diastolic blood pressure (SBP, DBP) and low-and high-density lipoprotein cholesterol (LDL, HDL) are independent predictors of CHD events later in life...

Marijuana use and risk of prediabetes and diabetes by middle adulthood: the Coronary Artery Risk Development in Young Adults (CARDIA) study

Aims/hypothesis The impact of marijuana use on metabolic health is largely unknown. This study sought to clarify the cross-sectional and longitudinal associations between self-reported marijuana use, and prediabetes (defined as fasting glucose 5.6–6.9 mmol/l, 2 h glucose post OGTT 7.8–11.0 mmol/l or HbA1c 5.7–6.4% [39–47 mmol/mol]) and diabetes. Methods Data from the community...

Direct Measurements of Smartphone Screen-Time: Relationships with Demographics and Sleep

Background Smartphones are increasingly integrated into everyday life, but frequency of use has not yet been objectively measured and compared to demographics, health information, and in particular, sleep quality. Aims The aim of this study was to characterize smartphone use by measuring screen-time directly, determine factors that are associated with increased screen-time, and...

Key emerging themes for assessing the cost-effectiveness of reporting incidental findings

the modeling approaches and estimates used. Kathryn?A.?Phillips, PhD1, Uri?Ladabaum,?MD, MS2,3, Mark?J.?Pletcher,?MD, MPH3,4, Deborah?A.?Marshall,?PhD3,5 and Michael?P.?Douglas,?MS3 1Department of

Fatherhood and the risk of cardiovascular mortality in the NIH-AARP Diet and Health Study

Background Fertility potential and reproductive fitness may reflect a man's future health, given that over one-third of the male human genome is involved in reproduction. We sought to determine if offspring number predicts cardiovascular death in the US men.

Framingham Risk Score and Alternatives for Prediction of Coronary Heart Disease in Older Adults

Background Guidelines for the prevention of coronary heart disease (CHD) recommend use of Framingham-based risk scores that were developed in white middle-aged populations. It remains unclear whether and how CHD risk prediction might be improved among older adults. We aimed to compare the prognostic performance of the Framingham risk score (FRS), directly and after recalibration...

Alcohol Consumption in Young Adults and Incident Hypertension: 20-Year Follow-up From the Coronary Artery Risk Development in Young Adults Study

, Birmingham, Alabama (Jewell H. Halanych, Stefan G. Kertesz, Young-Il Kim, Sharina D. Person, Cora E. Lewis); University of California, San Francisco, California (Mark J. Pletcher); and University of

Self-reported Racial Discrimination and Substance Use in the Coronary Artery Risk Development in Adults Study

The authors investigated whether substance use and self-reported racial discrimination were associated in the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Smoking status, alcohol consumption, and lifetime use of marijuana, amphetamines, and opiates were ascertained in 2000–2001, 15 years after baseline (1985–1986). Most of the 1,507 African Americans reported...

Alcohol Consumption, Binge Drinking, and Early Coronary Calcification: Findings from the Coronary Artery Risk Development in Young Adults (CARDIA) Study

It is unclear to what extent the apparently beneficial cardiovascular effects of moderate alcohol consumption are mediated by protection against atherosclerosis. Alcohol consumption, coronary heart disease risk factors, and coronary calcification (a marker of atherosclerosis) were measured during 15 years of follow-up in the Coronary Artery Risk Development in Young Adults...

What does my patient's coronary artery calcium score mean? Combining information from the coronary artery calcium score with information from conventional risk factors to estimate coronary heart disease risk

Background The coronary artery calcium (CAC) score is an independent predictor of coronary heart disease. We sought to combine information from the CAC score with information from conventional cardiac risk factors to produce post-test risk estimates, and to determine whether the score may add clinically useful information. Methods We measured the independent cross-sectional...