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Neighbourhood walkability and home neighbourhood-based physical activity: an observational study of adults with type 2 diabetes

Background Converging international evidence suggests that diabetes incidence is lower among adults living in more walkable neighbourhoods. The association between walkability and physical activity (PA), the presumed mediator of this relationship, has not been carefully examined in adults with type 2 diabetes. We investigated the associations of walkability with total PA...

Intratumoral heterogeneity as a source of discordance in breast cancer biomarker classification

Background Spatial heterogeneity in biomarker expression may impact breast cancer classification. The aims of this study were to estimate the frequency of spatial heterogeneity in biomarker expression within tumors, to identify technical and biological factors contributing to spatial heterogeneity, and to examine the impact of discordant biomarker status within tumors on clinical...

Relationship between crown-like structures and sex-steroid hormones in breast adipose tissue and serum among postmenopausal breast cancer patients

Background Postmenopausal obesity is associated with increased circulating levels of androgens and estrogens and elevated breast cancer risk. Crown-like structures (CLS; microscopic foci of dying adipocytes surrounded by macrophages) are proposed to represent sites of increased aromatization of androgens to estrogens. Accordingly, we examined relationships between CLS and sex...

Leukocyte telomere length and its association with mammographic density and proliferative diagnosis among women undergoing diagnostic image-guided breast biopsy

Background Elevated mammographic density (MD) is a strong breast cancer risk factor but the mechanisms underlying the association are poorly understood. High MD and breast cancer risk may reflect cumulative exposures to factors that promote epithelial cell division. One marker of cellular replicative history is telomere length, but its association with MD is unknown. We...

Relationships between mammographic density, tissue microvessel density, and breast biopsy diagnosis

Background Women with high levels of mammographic density (MD) have a four- to six-fold increased risk of developing breast cancer; however, most neither have a prevalent tumor nor will they develop one. Magnetic resonance imaging (MRI) studies suggest that background parenchymal enhancement, an indicator of vascularity, is related to increased breast cancer risk. Correlations of...

Transitioning to Glass Cockpit Primary Training Fleets: Implications

studies will need to be conducted in order to come to a viable conclusion. .) Mark Sherman is an assistant professor and interim department chair at Central Missouri State University. He is a Doctoral ... Sherman and Deak Arch Transitioningto Glass In late July, 2004, Ohio University had the unique opportunity to become a hnt-runner in one of the most significant revolutions in Technically Advanced

Prognostic value of automated KI67 scoring in breast cancer: a centralised evaluation of 8088 patients from 10 study groups

Background The value of KI67 in breast cancer prognostication has been questioned due to concerns on the analytical validity of visual KI67 assessment and methodological limitations of published studies. Here, we investigate the prognostic value of automated KI67 scoring in a large, multicentre study, and compare this with pathologists’ visual scores available in a subset of...

Upper airway compromise secondary to edema in Graves’ disease

de Graves] William Li Pi Shan FRCPC Roupen Hatzakorzian FRCPC Mark Sherman MDCM FRCPC MACP Steven B. Backman MDCM PHD FRCPC [Atteinte des voies ariennes suprieures secondaire un dme dans la

The Elevated 10-Year Risk of Cervical Precancer and Cancer in Women With Human Papillomavirus (HPV) Type 16 or 18 and the Possible Utility of Type-Specific HPV Testing in Clinical Practice

Background: Human papillomavirus (HPV) types 16 and 18 cause 60%–70% of cervical cancer worldwide, and other HPV types cause virtually all remaining cases. Pooled HPV testing for 13 oncogenic types, including HPV16 and 18, is currently used in clinical practice for triage of equivocal cytology and, in conjunction with Pap tests, is an option for general screening among women 30...

Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis

Carl Blomqvist Elena Provenzano Hamid Raza Ali Jonine Figueroa Mark Sherman Jolanta Lissowska Arto Mannermaa Vesa Kataja Veli-Matti Kosma Jaana M. Hartikainen Kelly-Anne Phillips kConFab/AOCS ... project managers, study nurses and research assistants, the heads and staff of the Family Cancer Clinics, and the Clinical Follow Up Study; Louise Brinton, Mark Sherman, Neonila Szeszenia-Dabrowska, Beata

Enrichment of putative PAX8 target genes at serous epithelial ovarian cancer susceptibility loci

Thomas A Sellers Mark Sherman Nadeem Siddiqui Weiva Sieh Honglin Song Melissa Southey Kathryn L Terry Shelley S Tworoger Christine Walsh Nicolas Wentzensen Alice S Whittemore Anna H Wu Hannah Yang Wei

Detection of Human Papillomavirus DNA in Cytologically Normal Women and Subsequent Cervical Squamous Intraepithelial Lesions

“Notes” following “References.” 2 Kai-Li Liaw , Andrew G. Glass, M. Michele Manos, Catherine E. Greer, David R. Scott, Mark Sherman, Robert D. Burk, Robert J. Kurman, Sholom Wacholder, Brenda B. Rush

The role of genetic breast cancer susceptibility variants as prognostic factors

Recent genome-wide association studies identified 11 single nucleotide polymorphisms (SNPs) associated with breast cancer (BC) risk. We investigated these and 62 other SNPs for their prognostic relevance. Confirmed BC risk SNPs rs17468277 (CASP8), rs1982073 (TGFB1), rs2981582 (FGFR2), rs13281615 (8q24), rs3817198 (LSP1), rs889312 (MAP3K1), rs3803662 (TOX3), rs13387042 (2q35...

Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2

Introduction Previous studies have demonstrated that common breast cancer susceptibility alleles are differentially associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. It is currently unknown how these alleles are associated with different breast cancer subtypes in BRCA1 and BRCA2 mutation carriers defined by estrogen (ER) or progesterone receptor (PR...