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10 papers found.
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Differential modulation of pulmonary caspases: Is this the key to Ureaplasma-driven chronic inflammation?

Silwedel, Markus Fehrholz, Christian P. Speer, Kirsten Glaser. Data curation: Christine Silwedel, Markus Fehrholz, Kirsten Glaser. Formal analysis: Christine Silwedel, Markus Fehrholz, Christian P. Speer ... : Markus Fehrholz. Supervision: Christine Silwedel, Christian P. Speer, Kirsten Glaser. Validation: Markus Fehrholz, Katharina C. Ruf, Steffi Manig, Kirsten Glaser. Visualization: Christine Silwedel

Effect of progesterone on Smad signaling and TGF-β/Smad-regulated genes in lung epithelial cells

Kunzmann, Barbara Ottensmeier. Funding acquisition: Steffen Kunzmann. Investigation: Barbara Ottensmeier. Methodology: Barbara Ottensmeier. Project administration: Steffen Kunzmann, Markus Fehrholz ... . Supervision: Steffen Kunzmann, Christian P. Speer, Markus Fehrholz. Validation: Steffen Kunzmann, Markus Fehrholz. Writing ? original draft: Steffen Kunzmann, Markus Fehrholz. Writing ? review & editing

Expression of surfactant protein B is dependent on cell density in H441 lung epithelial cells

. Author Contributions Conceptualization: Markus Fehrholz, Steffen Kunzmann. Data curation: Markus Fehrholz. Formal analysis: Markus Fehrholz, Silvia Seidenspinner. Investigation: Markus Fehrholz, Silvia ... Seidenspinner. Methodology: Markus Fehrholz, Silvia Seidenspinner. Project administration: Markus Fehrholz, Steffen Kunzmann. Supervision: Steffen Kunzmann. Validation: Markus Fehrholz. Visualization: Markus

Ureaplasma isolates stimulate pro-inflammatory CC chemokines and matrix metalloproteinase-9 in neonatal and adult monocytes

Dragan for excellent technical support and all cord blood donors for contributing to this study. Author Contributions Conceptualization: Kirsten Glaser, Christine Silwedel, Markus Fehrholz, Birgit ... Henrich, Christian P. Speer. Data curation: Kirsten Glaser. Formal analysis: Kirsten Glaser, Christine Silwedel, Markus Fehrholz, Birgit Henrich, Heike Claus, Christian P. Speer. 12 / 17 Funding

Effects of the New Generation Synthetic Reconstituted Surfactant CHF5633 on Pro- and Anti-Inflammatory Cytokine Expression in Native and LPS-Stimulated Adult CD14+ Monocytes

Background Surfactant replacement therapy is the standard of care for the prevention and treatment of neonatal respiratory distress syndrome. New generation synthetic surfactants represent a promising alternative to animal-derived surfactants. CHF5633, a new generation reconstituted synthetic surfactant containing SP-B and SP-C analogs and two synthetic phospholipids has...

Impact of the New Generation Reconstituted Surfactant CHF5633 on Human CD4+ Lymphocytes

Background Natural surfactant preparations, commonly isolated from porcine or bovine lungs, are used to treat respiratory distress syndrome in preterm infants. Besides biophysical effectiveness, several studies have documented additional immunomodulatory properties. Within the near future, synthetic surfactant preparations may be a promising alternative. CHF5633 is a new...

Caffeine and Rolipram Affect Smad Signalling and TGF-β1 Stimulated CTGF and Transgelin Expression in Lung Epithelial Cells

Caffeine administration is an important part of the therapeutic treatment of bronchopulmonary dysplasia (BPD) in preterm infants. However, caffeine mediated effects on airway remodelling are still undefined. The TGF-β/Smad signalling pathway is one of the key pathways involved in airway remodelling. Connective tissue growth factor (CTGF), a downstream mediator of TGF-β, and...

Multiple Antenatal Dexamethasone Treatment Alters Brain Vessel Differentiation in Newborn Mouse Pups

Antenatal steroid treatment decreases morbidity and mortality in premature infants through the maturation of lung tissue, which enables sufficient breathing performance. However, clinical and animal studies have shown that repeated doses of glucocorticoids such as dexamethasone and betamethasone lead to long-term adverse effects on brain development. Therefore, we established a...

Synergistic Effect of Caffeine and Glucocorticoids on Expression of Surfactant Protein B (SP-B) mRNA

Administration of glucocorticoids and caffeine is a common therapeutic intervention in the neonatal period, but possible interactions between these substances are still unclear. The present study investigated the effect of caffeine and different glucocorticoids on expression of surfactant protein (SP)-B, crucial for the physiological function of pulmonary surfactant. We measured...

IFN-γ and TNF-α Synergize to Inhibit CTGF Expression in Human Lung Endothelial Cells

Connective tissue growth factor (CTGF/CCN2) is an angiogenetic and profibrotic factor, acting downstream of TGF-β, involved in both airway- and vascular remodeling. While the T-helper 1 (Th1) cytokine interferon-gamma (IFN-γ) is well characterized as immune-modulatory and anti-fibrotic cytokine, the role of IFN-γ in lung endothelial cells (LEC) is less defined. Tumour necrosis...