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13 papers found.
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Sensitive mass spectrometric assay for determination of 15-deoxy-Δ12,14-prostaglandin J2 and its application in human plasma samples of patients with diabetes

The determination of individual prostaglandins (PG) in humans is mainly performed in urine samples. The quantification of PGs in human plasma could improve the understanding of particular PG species under various physiological and pathological conditions. 15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) is a dehydrated downstream product of PGD2 and is of high interest due to its...

Erratum to: The OECD validation program of the H295R steroidogenesis assay: Phase 3. Final inter-laboratory validation study

, Germany 1 Department of Veterinary Biomedical Sciences and Toxicology Centre, University of Saskatchewan , Saskatoon, Saskatchewan , Canada 2 Markus Hecker 3 Office of Science Coordination & Policy, US

Toward understanding the impacts of sediment contamination on a native fish species: transcriptional effects, EROD activity, and biliary PAH metabolites

Background Both frequency and intensity of flood events are expected to increase as a result of global climate change in the upcoming decades, potentially resulting in increased re-suspension of sediments in fluvial systems. Contamination of these re-suspended sediments with legacy contaminants, including dioxins and dioxin-like compounds (DLCs), as well as polycyclic aromatic...

Toward understanding the impacts of sediment contamination on a native fish species: transcriptional effects, EROD activity, and biliary PAH metabolites

Background Both frequency and intensity of flood events are expected to increase as a result of global climate change in the upcoming decades, potentially resulting in increased re-suspension of sediments in fluvial systems. Contamination of these re-suspended sediments with legacy contaminants, including dioxins and dioxin-like compounds (DLCs), as well as polycyclic aromatic...

Endocrine disruptor screening: regulatory perspectives and needs

Markus Hecker 1 Henner Hollert henner.hollert@bio5.rwth-aachen 0 0 Department of Ecosystem Analysis, Institute for Environmental Research, RWTH Aachen University , Worringerweg 1, 52074 Aachen

Project house water: a novel interdisciplinary framework to assess the environmental and socioeconomic consequences of flood-related impacts

Protecting our water resources in terms of quality and quantity is considered one of the big challenges of the twenty-first century, which requires global and multidisciplinary solutions. A specific threat to water resources, in particular, is the increased occurrence and frequency of flood events due to climate change which has significant environmental and socioeconomic impacts...

Effect-directed analysis (EDA) in aquatic ecotoxicology: state of the art and future challenges

Markus Hecker Henner Hollert 0 ) Institute for Environmental Research (Biology V), Department for Ecosystem Analysis, RWTH Aachen University , 52074 Aachen, Germany (TIE) approach, had been

Contribution of Priority PAHs and POPs to Ah Receptor-Mediated Activities in Sediment Samples from the River Elbe Estuary, Germany

Jens C. Otte Steffen Keiter Christopher Fabender Eric B. Higley Paula Suares Rocha Markus Brinkmann Dierk-Steffen Wahrendorf Werner Manz Markus A. Wetzel Thomas Braunbeck John P. Giesy Markus Hecker

A new approach to investigate the interactions between sediment transport and ecotoxicological processes during flood events

Catrina Cofalla cofalla@iww.rwth- 0 Roy M Frings 0 Sabine U Gerbersdorf Markus Hecker Sebastian Hudjetz Ulrike Kammann Gottfried Lennartz Sebastian Roger 0 Andreas Schäffer Henner Hollert 0 Institute of

STAT-1 decoy oligodeoxynucleotide inhibition of acute rejection in mouse heart transplants

During acute rejection of cardiac transplants endothelial cell–leukocyte interaction fuelled by co-stimulatory molecules like CD40/CD154 may ultimately lead to graft loss. One key player in up-regulating the expression of such pro-inflammatory gene products is the interferon-γ-dependent transcription factor STAT-1. Hence down-regulating interferon-γ-stimulated pro-inflammatory...

ARGININE CHALLENGE UNRAVELS PERSISTENT DISTURBANCES OF UREA CYCLE AND GLUCONEOGENESIS IN ABSTINENT ALCOHOLICS

Aims: Data on recovery from hormonal and metabolic sequelae of alcoholism in strictly controlled alcohol abstinence are mainly restricted to short-term abstention. Our previous findings of persistently decreased plasma and urinary urea concentrations in long-term abstinent alcoholics prompted us to further elucidate this unexplained phenomenon. Methods: The response of...

Attenuation of murine antigen-induced arthritis by treatment with a decoy oligodeoxynucleotide inhibiting signal transducer and activator of transcription-1 (STAT-1)

The transcription factor STAT-1 (signal transducer and activator of transcription-1) plays a pivotal role in the expression of inflammatory gene products involved in the pathogenesis of arthritis such as various cytokines and the CD40/CD40 ligand (CD40/CD40L) receptor-ligand dyad. The therapeutic efficacy of a synthetic decoy oligodeoxynucleotide (ODN) binding and neutralizing...