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Adverse Outcome Pathway (AOP) Development I: Strategies and Principles

Daniel L. Villeneuve 3 Doug Crump 0 Nata` lia Garcia-Reyero 2 Markus Hecker 5 Thomas H. Hutchinson 4 Carlie A. LaLone 3 jj Brigitte Landesmannjjj Teresa Lettierijjj Sharon Munnjjj Malgorzata

Adverse Outcome Pathway Development II: Best Practices

Daniel L. Villeneuve 3 Doug Crump 0 Nata` lia Garcia-Reyero 2 Markus Hecker 5 Thomas H. Hutchinson 4 Carlie A. LaLone 3 k Brigitte Landesmannjjj Teresa Lettierijjj Sharon Munnjjj Malgorzata

Bisphenol A Disrupts Steroidogenesis in Human H295R Cells

Xiaowei Zhang Hong Chang Steve Wiseman Yuhe He Eric Higley Paul Jones Chris K.C. Wong Abdulaziz Al-Khedhairy jj John P. Giesy jj jjj jjjj Markus Hecker There is increasing concern over the risk of

Effects of Atrazine on CYP19 Gene Expression and Aromatase Activity in Testes and on Plasma Sex Steroid Concentrations of Male African Clawed Frogs (Xenopus laevis)

Some investigators have suggested that the triazine herbicide atrazine can cause demasculinization of male amphibians via upregulation of the enzyme aromatase. Male adult African clawed frogs (Xenopus laevis) were exposed to three nominal concentrations of atrazine (1, 25, or 250μg atrazine/l) for 36 days, and testicular aromatase activity and CYP19 gene expression, as well as...