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Search: authors:"Martin L. Privalsky"

4 papers found.
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Evolution of NCoR-1 and NCoR-2 corepressor alternative mRNA splicing in placental mammals

The NCoR-1 and NCoR-2 corepressors are products of an early gene duplication near the beginning of vertebrate evolution and play both overlapping and divergent roles in development and physiology. Alternative-splicing of NCoR-1 and NCoR-2 further customizes their functions. To better understand the evolutionary basis of this phenomenon we extended our prior study of NCoR-1 and...

Thyroid Hormone Receptor Mutations in Cancer and Resistance to Thyroid Hormone: Perspective and Prognosis

-Davis, Davis, CA 95616, USA Received 2 February 2011; Accepted 16 March 2011 Academic Editor: Michelina Plateroti Copyright © 2011 Meghan D. Rosen and Martin L. Privalsky. This is an open access

Thyroid Hormone Receptor Mutations in Cancer and Resistance to Thyroid Hormone: Perspective and Prognosis

-Davis, Davis, CA 95616, USA Received 2 February 2011; Accepted 16 March 2011 Academic Editor: Michelina Plateroti Copyright © 2011 Meghan D. Rosen and Martin L. Privalsky. This is an open access

Multiple mutations contribute to repression by the v-Erb A oncoprotein

The v-Erb A oncoprotein of avian erythroblastosis virus is derived from c-Erb A, a hormone-activated transcription factor. Notably, v-Erb A has sustained multiple mutations relative to c-Erb A and functions as a constitutive transcriptional repressor. We report here an analysis of the contributions of these different mutations to v-Erb A function. Our experiments demonstrate that...