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15 papers found.
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Lamivudine monotherapy as a holding regimen for HIV-positive children

Institutes of Health. The authors would like to acknowledge all patients, caregivers, and data managers involved in IeDEA-SA cohorts. Principal investigators: Mary-Ann Davies, Centre for Infectious Disease ... , Mary Ann Davies. Investigation: Lee Fairlie. Methodology: Gabriela Patten, Lee Fairlie. Project administration: Gabriela Patten. Supervision: Mary-Ann Davies. Visualization: Gabriela Patten

Acceptability and performance of a directly assisted oral HIV self-testing intervention in adolescents in rural Mozambique

, Laura Frances Jefferys. Data curation: Jonas Hector, Laura Frances Jefferys. 8 / 11 Formal analysis: Jonas Hector, Mary-Ann Davies, Laura Frances Jefferys. Investigation: Jonas Hector, Cassimo Charifo A ... . Supervision: Jonas Hector, Cassimo Charifo A. Abdalad, Laura Frances Jefferys. Validation: Laura Frances Jefferys. Writing ± original draft: Jonas Hector. Writing ± review & editing: Jonas Hector, Mary-Ann

Growth of HIV-Exposed Uninfected Infants in the First 6 Months of Life in South Africa: The IeDEA-SA Collaboration

Background HIV-exposed uninfected (HEU) infants are a growing population in sub-Saharan Africa especially with the increasing coverage of more effective prevention of mother-to-child transmission (PMTCT) antiretroviral therapy regimens. This study describes the characteristics of South African HEU infants, investigates factors impacting birth weight and assesses their growth...

First-line antiretroviral drug discontinuations in children

Introduction There are a limited number of paediatric antiretroviral drug options. Characterising the long term safety and durability of different antiretrovirals in children is important to optimise management of HIV infected children and to determine the estimated need for alternative drugs in paediatric regimens. We describe first-line antiretroviral therapy (ART) durability...

Provider-Initiated HIV Testing and Counselling for Children

Mary-Ann Davies and Emma Kalk reflect on recent research by Rashida Ferrand and colleagues into barriers to provider-initiated HIV testing for older children in Zimbabwe. Please see later in the

Clinical Mentorship of Nurse Initiated Antiretroviral Therapy in Khayelitsha, South Africa: A Quality of Care Assessment

Introduction To combat the AIDS epidemic and increase HIV treatment access, the South African government implemented a nurse-based, doctor-supported model of care that decentralizes administration of antiretroviral treatment (ART) for HIV positive patients through nurse initiated and managed ART. Médecins Sans Frontières (MSF) implemented a mentorship programme to ensure...

Targeted Spontaneous Reporting: Assessing Opportunities to Conduct Routine Pharmacovigilance for Antiretroviral Treatment on an International Scale

participating IeDEA-SA sites for completing the site assessment and contributing to the IeDEA-SA collaboration. Thanks to the IeDEA-SA Data Centre teams at the Universities of Cape Town (Mary-Ann Davies [PI ... . Conflict of interest Beth Rachlis, Rakhi Karwa, Celia Chema, Sonak Pastakia, Sten Olsson, Beatrice Jakait, Mercy Maina, Nagalingeswaran Kumarsamy, Stephany N Duda, Mary-Ann Davies, and Paula Braitstein have

Retention in Care of HIV-Infected Children from HIV Test to Start of Antiretroviral Therapy: Systematic Review

-Ann Davies 0 Katharina Kranzer, London School of Hygiene and Tropical Medicine, United Kingdom 0 1 Division of International and Environmental Health, Institute of Social and Preventive Medicine (ISPM

Effect of Baseline Renal Function on Tenofovir-Containing Antiretroviral Therapy Outcomes in Zambia

Background. Although tenofovir disoproxil fumarate (TDF) use has increased as part of first-line antiretroviral therapy (ART) across sub-Saharan Africa, renal outcomes among patients receiving TDF remain poorly understood. We assessed changes in renal function and mortality in patients starting TDF- or non–TDF-containing ART in Lusaka, Zambia. Methods. We included patients aged...

Adherence to antiretroviral therapy in young children in Cape Town, South Africa, measured by medication return and caregiver self-report: a prospective cohort study

High School and the University of Cape Town. Mary-Ann Davies and Andrew Boulle receive support from the International Epidemiological Databases to Evaluate AIDS in Southern Africa (IeDEASA) collaboration

Temporal Trends in the Characteristics of Children at Antiretroviral Therapy Initiation in Southern Africa: The IeDEA-SA Collaboration

Background Since 2005, increasing numbers of children have started antiretroviral therapy (ART) in sub-Saharan Africa and, in recent years, WHO and country treatment guidelines have recommended ART initiation for all infants and very young children, and at higher CD4 thresholds for older children. We examined temporal changes in patient and regimen characteristics at ART start...

Monitoring of Antiretroviral Therapy and Mortality in HIV Programmes in Malawi, South Africa and Zambia: Mathematical Modelling Study

Objectives Mortality in patients starting antiretroviral therapy (ART) is higher in Malawi and Zambia than in South Africa. We examined whether different monitoring of ART (viral load [VL] in South Africa and CD4 count in Malawi and Zambia) could explain this mortality difference. Design: Mathematical modelling study based on data from ART programmes. Methods We used a stochastic...

When to Start Antiretroviral Therapy in Children Aged 2–5 Years: A Collaborative Causal Modelling Analysis of Cohort Studies from Southern Africa

Olivia Keiser Mary-Ann Davies for the International Epidemiologic Databases to Evaluate AIDS-Southern Africa (IeDEA-SA) Collaboration Steven G. Deeks, San Francisco General Hospital, United States of

Reversion and conversion of Mycobacterium tuberculosis IFN-γ ELISpot results during anti-tuberculous treatment in HIV-infected children

Background Recent interest has focused on the potential use of serial interferon gamma (IFN-γ) release assay (IGRA) measurements to assess the response to anti-tuberculous (TB) treatment. The kinetics of IFN-γ responses to Mycobacterium tuberculosis (MTB) antigens in HIV-infected children during treatment have not however been previously investigated. Methods IFN-γ responses to...