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33 papers found.
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Evaluation of Dynamic Tumor-tracking Intensity-modulated Radiotherapy for Locally Advanced Pancreatic Cancer

Intensity-modulated radiotherapy (IMRT) is now regarded as an important treatment option for patients with locally advanced pancreatic cancer (LAPC). To reduce the underlying tumor motions and dosimetric errors during IMRT as well as the burden of respiratory management for patients, we started to apply a new treatment platform of the dynamic tumor dynamic tumor-tracking...

UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization

Morinibu Michio Yoshimura Masahiro Hiraoka Ester M. Hammond Hiroshi Harada OPEN Hypoxia-inducible factor 1 (HIF-1) has been recognized as an important mediator of the reprogramming of carbohydrate metabolic

Non-coplanar volumetric-modulated arc therapy (VMAT) for craniopharyngiomas reduces radiation doses to the bilateral hippocampus: a planning study comparing dynamic conformal arc therapy, coplanar VMAT, and non-coplanar VMAT

Background Recent studies suggest that radiation-induced injuries to the hippocampus play important roles in compromising neurocognitive functioning for patients with brain tumors and it could be important to spare the hippocampus using modern planning methods for patients with craniopharyngiomas. As bilateral hippocampus are located on the same level as the planning target...

ALC1/CHD1L, a chromatin-remodeling enzyme, is required for efficient base excision repair

, Reiko Watanabe, Yuka Nakazawa, Hiroshi Harada, Keli Agama, Jun Nakamura, Ryuta Asada, Haruna Fujiike, Tetsushi Sakuma, Junko Murai, Masahiro Hiraoka, Kaoru Koike, Kouji Hirota. Methodology: Takashi

PLK1 blockade enhances therapeutic effects of radiation by inducing cell cycle arrest at the mitotic phase

Morinibu, Satoshi Itasaka, Masahiro Hiraoka & Hiroshi HaradaGroup of Radiation and Tumor Biology, Career-Path Promotion Unit for Young Life Scientists, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto ... Morinibu in:Nature Research journals • PubMed • Google ScholarSearch for Satoshi Itasaka in:Nature Research journals • PubMed • Google ScholarSearch for Masahiro Hiraoka in:Nature Research journals • PubMed

Comparison of the pharmacokinetics between L-BPA and L-FBPA using the same administration dose and protocol: a validation study for the theranostic approach using [ 18 F]-L-FBPA positron emission tomography in boron neutron capture therapy

-ichiro Masunaga Masahiro Hiraoka Koji Ono Minoru Suzuki Mitsunori Kirihata 0 0 Research Center of Boron Neutron Capture Therapy, Research Organization for the 21st Century, Osaka Prefecture University , 1

Surveillance on interfacility differences in dose-prescription policy of intensity-modulated radiation therapy plans for prostate cancer

Takashi MIZOWAKI 0 Kazuo HATANO 0 Masahiro HIRAOKA 0 0 Number of institutions Intensity-modulated radiation therapy (IMRT) has recently become popular in Japan. Prostate cancer is indisputably one

Initial characterization, dosimetric benchmark and performance validation of Dynamic Wave Arc

Background Dynamic Wave Arc (DWA) is a clinical approach designed to maximize the versatility of Vero SBRT system by synchronizing the gantry-ring noncoplanar movement with D-MLC optimization. The purpose of this study was to verify the delivery accuracy of DWA approach and to evaluate the potential dosimetric benefits. Methods DWA is an extended form of VMAT with a continuous...

Assessment of interfractional prostate motion in patients immobilized in the prone position using a thermoplastic shell

The aim of this study was to evaluate the interfractional prostate motion of patients immobilized in the prone position using a thermoplastic shell. A total of 24 patients with prostate calcifications detectable using a kilo-voltage X-ray image-guidance system (ExacTrac X-ray system) were examined. Daily displacements of the calcification within the prostate relative to pelvic...

Initial and cumulative recurrence patterns of glioblastoma after temozolomide-based chemoradiotherapy and salvage treatment: a retrospective cohort study in a single institution

Purpose To analyze initial recurrence patterns in patients with newly diagnosed glioblastoma after radiotherapy plus concurrent and adjuvant temozolomide, and to investigate cumulative recurrence patterns after salvage treatment, including surgery, stereotactic radiotherapy, and chemotherapy. Methods Twenty-one patients with glioblastoma that recurred after concurrent...

The impact of abdominal compression on outcome in patients treated with stereotactic body radiotherapy for primary lung cancer

Wambaka Ange MAMPUYA Yukinori MATSUO Nami UEKI Mitsuhiro NAKAMURA Nobutaka MUKUMOTO Akira NAKAMURA Yusuke IIZUKA Takahiro KISHI Takashi MIZOWAKI Masahiro HIRAOKA The aim of this study was to

Protection of Cardiomyocytes from the Hypoxia-Mediated Injury by a Peptide Targeting the Activator of G-Protein Signaling 8

Signaling via heterotrimeric G-protein is involved in the development of human diseases including ischemia-reperfusion injury of the heart. We previously identified an ischemia-inducible G-protein activator, activator of G-protein signaling 8 (AGS8), which regulates Gβγ signaling and plays a key role in the hypoxia-induced apoptosis of cardiomyocytes. Here, we attempted to...

Feasibility evaluation of a new irradiation technique: three-dimensional unicursal irradiation with the Vero4DRT (MHI-TM2000)

The Vero4DRT (MHI-TM2000) is a newly designed unique image-guided radiotherapy system consisting of an O-ring gantry. This system can realize a new irradiation technique in which both the gantry head and O-ring continuously and simultaneously rotate around the inner circumference of the O-ring and the vertical axis of the O-ring, respectively, during irradiation. This technique...

Two cases of radiation-induced cutaneous angiosarcoma

We report two cases of radiation-induced cutaneous angiosarcoma that occurred years after radiotherapy for pelvic cancer. The tumors in both cases were inoperable because of the poor performance status of the patient or the extent of the lesion. We treated the tumors with concurrent chemotherapy and radiotherapy. The chemotherapy consisted of the weekly administration of 70 mg/m2...

Differences in the dose–volume metrics with heterogeneity correction status and its influence on local control in stereotactic body radiation therapy for lung cancer

Nami UEKI Yukinori MATSUO Keiko SHIBUYA Mitsuhiro NAKAMURA Masaru NARABAYASHI Katsuyuki SAKANAKA Yoshiki NORIHISA Takashi MIZOWAKI Masahiro HIRAOKA The purpose of this

Dosimetric evaluation of the impacts of different heterogeneity correction algorithms on target doses in stereotactic body radiation therapy for lung tumors

Masaru NARABAYASHI Takashi MIZOWAKI Yukinori MATSUO Mitsuhiro NAKAMURA Kenji TAKAYAMA Yoshiki NORIHISA Katsuyuki SAKANAKA Masahiro HIRAOKA Heterogeneity correction algorithms can have a large impact

Distribution patterns of metastatic pelvic lymph nodes assessed by CT/MRI in patients with uterine cervical cancer

Goro Kasuya 0 Takafumi Toita 0 Kazuhisa Furutani Takeshi Kodaira Tatsuya Ohno Yuko Kaneyasu Ryouichi Yoshimura Takashi Uno Akira Yogi 0 Satoshi Ishikura Masahiro Hiraoka 0 Department of Radiology

Interference in DNA Replication Can Cause Mitotic Chromosomal Breakage Unassociated with Double-Strand Breaks

Morphological analysis of mitotic chromosomes is used to detect mutagenic chemical compounds and to estimate the dose of ionizing radiation to be administered. It has long been believed that chromosomal breaks are always associated with double-strand breaks (DSBs). We here provide compelling evidence against this canonical theory. We employed a genetic approach using two cell...