Advanced search    

Search: authors:"Masahiro Nakashima"

34 papers found.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

Mouse models of sporadic thyroid cancer derived from BRAFV600E alone or in combination with PTEN haploinsufficiency under physiologic TSH levels

, Japan for providing a rat lung tumor tissue. Author Contributions Conceptualization: Masanobu Yamada, Yuji Nagayama. zaki, Masahiro Nakashima. Funding acquisition: Masanobu Yamada, Yuji Nagayama ... . Investigation: Masahiro Nakashima. Data curation: Mika Shimamura, Nobuyuki Shibusawa, Tomomi Kurashige, Hiroki MatsuMethodology: Mika Shimamura, Nobuyuki Shibusawa, Tomomi Kurashige, Zhanna Mussazhanova

Activation and increase of radio-sensitive CD11b+ recruited Kupffer cells/macrophages in diet-induced steatohepatitis in FGF5 deficient mice

We have recently reported that Kupffer cells consist of two subsets, radio-resistant resident CD68+ Kupffer cells and radio-sensitive recruited CD11b+ Kupffer cells/macrophages (Mφs). Non-alcoholic steatohepatitis (NASH) is characterized not only by hepatic steatosis but also chronic inflammation and fibrosis. In the present study, we investigated the immunological mechanism of...

Hsa-miR-520d-5p promotes survival in human dermal fibroblasts exposed to a lethal dose of UV irradiation

Medicine, Tottori University, Yonago, JapanYoshitaka Ishihara, Satoshi Tsuno, Bingqiong Ping, Taichiro Ashizaki, Masahiro Nakashima, Taro Yamashita, Junichi Hasegawa & Norimasa MiuraPEZY-Pharma, Yonago ... ScholarSearch for Masahiro Nakashima in:Nature Research journals • PubMed • Google ScholarSearch for Keigo Miura in:Nature Research journals • PubMed • Google ScholarSearch for Yugo Miura in:Nature Research

Rapid growth of mitotically active cellular fibroma of the ovary: a case report and review of the literature

Background Mitotically active cellular fibroma (MACF) of the ovary, characterized by relatively high mitotic activity without severe atypia, represents a relatively new disease entity. MACF is categorized as a benign ovarian tumor. However, due to a limited number of case reports, its clinical and pathological features and optimum management remains largely undetermined. Herein...

Toyocamycin attenuates free fatty acid-induced hepatic steatosis and apoptosis in cultured hepatocytes and ameliorates nonalcoholic fatty liver disease in mice

Background and aims A high serum level of saturated free fatty acids (FFAs) is associated with the development of nonalcoholic fatty liver disease (NAFLD). X-box binding protein-1 (XBP-1) is activated by FFA treatment upon splicing. XBP-1 is a transcription factor induced by the endoplasmic reticulum (ER) stress sensor endoribonuclease inositol-requiring enzyme 1 alpha (IRE1...

Mouse CD11b+Kupffer Cells Recruited from Bone Marrow Accelerate Liver Regeneration after Partial Hepatectomy

TNF and Fas/FasL are vital components, not only in hepatocyte injury, but are also required for hepatocyte regeneration. Liver F4/80+Kupffer cells are classified into two subsets; resident radio-resistant CD68+cells with phagocytic and bactericidal activity, and recruited radio-sensitive CD11b+cells with cytokine-producing capacity. The aim of this study was to investigate the...

Effect of age on the sensitivity of the rat thyroid gland to ionizing radiation

Exposure to ionizing radiation during childhood is a well-known risk factor for thyroid cancer. Our study evaluated the effect of age on the radiosensitivity of rat thyroid glands. Four-week-old (4W), 7 -week-old (7W), and 8-month-old (8M) male Wistar rats were exposed to 8 Gy of whole-body X-ray irradiation. Thyroids were removed 3–72 h after irradiation, and non-irradiated...

Intra-uterine microbial colonization and occurrence of endometritis in women with endometriosis†

STUDY QUESTION Is there any risk of intra-uterine bacterial colonization and concurrent occurrence of endometritis in women with endometriosis?

Internal exposure to neutron-activated 56Mn dioxide powder in Wistar rats—Part 2: pathological effects

conflict of interest; Author Zhanna Mussazhanova declares that she has no conflict of interest; Author Daisuke Niino declares that he has no conflict of interest; Author Masahiro Nakashima declares that he

Occult microscopic endometriosis: undetectable by laparoscopy in normal peritoneum

STUDY QUESTION Is there any occurrence of hidden (occult) endometriotic lesions in normal peritoneum of women with and without visible endometriosis?

Involvement of the TNF and FasL Produced by CD11b Kupffer Cells/Macrophages in CCl4-Induced Acute Hepatic Injury

We previously reported that F4/80+ Kupffer cells are subclassified into CD68+ Kupffer cells with phagocytic and ROS producing capacity, and CD11b+ Kupffer cells with cytokine-producing capacity. Carbon tetrachloride (CCl4)-induced hepatic injury is a well-known chemical-induced hepatocyte injury. In the present study, we investigated the immunological role of Kupffer cells...

Low VHL mRNA Expression is Associated with More Aggressive Tumor Features of Papillary Thyroid Carcinoma

Alterations of the von Hippel–Lindau (VHL) tumor suppressor gene can cause different hereditary tumors associated with VHL syndrome, but the potential role of the VHL gene in papillary thyroid carcinoma (PTC) has not been characterized. This study set out to investigate the relationship of VHL expression level with clinicopathological features of PTC in an ethnically and...

Antitumor Immunity Produced by the Liver Kupffer Cells, NK Cells, NKT Cells, and CD8

Mouse and human livers contain innate immune leukocytes, NK cells, NKT cells, and macrophage-lineage Kupffer cells. Various bacterial components, including Toll-like receptor (TLR) ligands and an NKT cell ligand (α-galactocylceramide), activate liver Kupffer cells, which produce IL-1, IL-6, IL-12, and TNF. IL-12 activates hepatic NK cells and NKT cells to produce IFN-γ, which...

Antitumor Immunity Produced by the Liver Kupffer Cells, NK Cells, NKT Cells, and CD8

+ CD122+ T Cells Shuhji Seki, Hiroyuki Nakashima, Masahiro Nakashima, and Manabu Kinoshita Department of Immunology and Microbiology, National Defense Medical College, Namiki-3-2, Tokorozawa, Saitama 358

Additive effects of inflammation and stress reaction on Toll-like receptor 4-mediated growth of endometriotic stromal cells

STUDY QUESTION Is there any combined effect between inflammation and stress reaction on Toll-like receptor 4 (TLR4)-mediated growth of endometriotic cells?

The Effect of Synthetic C-Reactive Protein on the In Vitro Immune Response of Human PBMCs Stimulated with Bacterial Reagents

Synthetic C-reactive protein (CRP) rescues mice from lethal endotoxin shock or bacterial infection by suppressing tumor necrosis factor (TNF-α), but in turn, enhances Kupffer cell phagocytic activity. We herein assessed the influence of CRP in human peripheral blood mononuclear cells (PBMCs). When human PBMCs were stimulated in vitro with penicillin-treated Streptococcus pyogenes...

Infliximab therapy for Crohn’s-like disease in common variable immunodeficiency complicated by massive intestinal hemorrhage: a case report

Background Common variable immune deficiency is the most frequently encountered immunodeficiency in adults, which is characterized by low levels of serum immunoglobulins. Common variable immune deficiency can present with inflammatory bowel disease-like colitis because of the dysregulated immune system; paradoxically activated T cell receptor pathways are thought to be pivotal in...

The Effect of Varying Sound Velocity on Primordial Curvature Perturbations

We study the effects of sudden change in the sound velocity on primordial curvature perturbation spectrum in inflationary cosmology, assuming that the background evolution satisfies the slow-roll condition throughout. It is found that the power spectrum acquires oscillating features which are determined by the ratio of the sound speed before and after the transition and the...