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Search: authors:"Masami Arai"

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Five screening-detected breast cancer cases in initially disease-free BRCA1 or BRCA2 mutation carriers

Individuals carrying pathogenic BRCA1 or BRCA2 mutations have an increased lifetime risk of breast and/or ovarian cancer. The incidence of breast cancer amongst disease-free BRCA mutation carriers under surveillance and the clinical and pathological characteristics of those who subsequently develop the disease remain unclear in Japan. We reviewed the records of 155 individuals...

High rate of occult cancer found in prophylactic mastectomy specimens despite thorough presurgical assessment with MRI and ultrasound: findings from the Hereditary Breast and Ovarian Cancer Registration 2016 in Japan

PurposeProphylactic surgery is a preemptive strategy for hereditary breast and ovarian cancer (HBOC). Prophylactic mastectomy (PM) reduces breast cancer risk by >‚ÄČ90%. The aim of our study is to analyze the information of the Japanese pedigrees and to utilize the results for clinical practice.MethodsWe statistically analyzed records of HBOC registrees who had undergone BRCA1/2...

Decreased hormonal sensitivity after childbirth rather than the tumor size influences the prognosis of very young breast cancer patients

Ito 2 Naoya Gomi 1 Masahiko Oguchi 6 Mizuho Kita 5 Masami Arai 5 Futoshi Akiyama 4 Takuji Iwase 3 0 Department of Breast Surgery, Nippon Medical School Musashi Kosugi Hospital , 1-396 Kosugi-machi