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Food availability before aestivation governs growth and winter reproductive potential in the capital breeding fish, Ammodytes japonicus

. Supervision: Takeshi Tomiyama. 13 / 16 Validation: Michio Yoneda, Masanori Takahashi, Naoaki Kono. Writing ? original draft: Hirotsune Kuzuhara. Writing ? review & editing: Takeshi Tomiyama. 14 / 16 29

Erratum to: Hemodynamic effect of the left gastric artery on esophageal varices in patients with cirrhosis

Taro Shimada 0 Masanori Takahashi 0 Osamu Yokosuka 0 0 Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University , Chiba , Japan The author would like to correct the

Linoleate appears to protect against palmitate-induced inflammation in Huh7 cells

Background Polyunsaturated fatty acids (PUFAs) may protect against metabolic diseases. Although the benefits of the n-3 family of PUFA have been well investigated in nonalcoholic steatohepatitis (NASH), little is known about the effect of the n-6 family. This study examined the effect of linoleate, a member of the n-6 family, on regulation of the palmitate-induced inflammatory...

A Phox2b BAC Transgenic Rat Line Useful for Understanding Respiratory Rhythm Generator Neural Circuitry

The key role of the respiratory neural center is respiratory rhythm generation to maintain homeostasis through the control of arterial blood pCO2/pH and pO2 levels. The neuronal network responsible for respiratory rhythm generation in neonatal rat resides in the ventral side of the medulla and is composed of two groups; the parafacial respiratory group (pFRG) and the pre-B...

Expression study of cadherin7 and cadherin20 in the embryonic and adult rat central nervous system

Background Vertebrate classic cadherins are divided into type I and type II subtypes, which are individually expressed in brain subdivisions (e.g., prosomeres, rhombomeres, and progenitor domains) and in specific neuronal circuits in region-specific manners. We reported previously the expression of cadherin19 (cad19) in Schwann cell precursors. Cad19 is a type II classic cadherin...

Demonstration of intrahepatic accumulated microbubble on ultrasound represents the grade of hepatic fibrosis

Hiroyuki Ishibashi Hitoshi Maruyama Masanori Takahashi Taro Shimada Hidehiro Kamesaki Keiichi Fujiwara Fumio Imazeki Osamu Yokosuka Objectives To examine the feasibility of perflubutane-based

Discovery of a spawning area of the common Japanese conger Conger myriaster along the Kyushu-Palau Ridge in the western North Pacific

The common Japanese conger Conger myriaster is an important commercial coastal fisheries species in East Asia, but its spawning area has not been determined. A larval sampling survey was conducted in September 2008 along 136°E between 13°N and 22°N, which roughly followed the Kyushu-Palau Ridge in the western North Pacific. Twenty larval specimens were confirmed to be C...

Patterns of Neurogenesis and Amplitude of Reelin Expression Are Essential for Making a Mammalian-Type Cortex

The mammalian neocortex is characterized as a six-layered laminar structure, in which distinct types of pyramidal neurons are distributed coordinately during embryogenesis. In contrast, no other vertebrate class possesses a brain region that is strictly analogous to the neocortical structure. Although it is widely accepted that the pallium, a dorsal forebrain region, is specified...

Downstream genes of Pax6 revealed by comprehensive transcriptome profiling in the developing rat hindbrain

Background The transcription factor Pax6 is essential for the development of the central nervous system and it exerts its multiple functions by regulating the expression of downstream target molecules. To screen for genes downstream of Pax6, we performed comprehensive transcriptome profiling analyses in the early hindbrain of Pax6 homozygous mutant and wild-type rats using...

Specification of cell fate along the proximal-distal axis in the developing chick limb bud

Kosei Sato Yutaka Koizumi Masanori Takahashi Atsushi Kuroiwa Koji Tamura Pattern formation along the proximal-distal (PD) axis in the developing limb bud serves as a good model for learning how cell

Pax6 regulates specification of ventral neurone subtypes in the hindbrain by establishing progenitor domains

Masanori Takahashi 0 Noriko Osumi ) 0 0 Department of Developmental Neurobiology, Tohoku University Graduate School of Medicine , 2-1, Seiryo-machi, Aoba-ku, Sendai 980-8575 , Japan - Recent

Molecular Marker Identification for Relapse Prediction in 5-FU-Based Adjuvant Chemotherapy in Gastric and Colorectal Cancers

To confirm the clinical significance of NF-κB and JNK protein expression from experimentally identified candidates for predicting prognosis for patients with 5-FU treatment, we evaluated the protein expression of surgically removed specimens. A total of 79 specimens were obtained from 30 gastric and 49 colorectal cancer patients who underwent R0 resection followed by...

p53 mutations in tumor and non-tumor tissues of Thorotrast recipients: a model for cellular selection during radiation carcinogenesis in the liver

Concerns over cancer development from exposure to environmental sources of densely ionizing, high linear energy transfer (LET) radiation, such as α-particles from radon, is a current public health issue. The study of tumors attributable to high LET irradiation would greatly augment our insights into the biological mechanisms of carcinogenesis. Chronic low-dose-rate internal...