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22 papers found.
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The osteopontin-CD44 axis in hepatic cancer stem cells regulates IFN signaling and HCV replication

, Kanazawa University Graduate School of Health Medicine, Kanazawa, JapanTakayoshi Shirasaki, Masao Honda, Ryougo Shimizu, Saki Nakasyo & Kazuhisa MuraiDepartment of General Medicine, Kanazawa University ... Search for Masao Honda in:Nature Research journals • PubMed • Google Scholar Search for Taro Yamashita in:Nature Research journals • PubMed • Google Scholar Search for Kouki Nio in:Nature Research

Immune Condition of Colorectal Cancer Patients Featured by Serum Chemokines and Gene Expressions of CD4

Miyazawa,2 Norihiko Ogawa,1 Akihiro Seki,1 Masao Honda,4 Takashi Wada,5 Shigeyuki Matsui,3 Shuichi Kaneko,1,4 and Yoshio Sakai4 1System Biology, Graduate School of Advanced Preventive Medical Sciences ... Akihiro Seki contributed to acquisition of data and analysis of data. Masao Honda and Takashi Wada contributed to analysis of data and interpretation of data. Shigeyuki Matsui and Shuichi Kaneko contributed

Immune Condition of Colorectal Cancer Patients Featured by Serum Chemokines and Gene Expressions of CD4

Miyazawa,2 Norihiko Ogawa,1 Akihiro Seki,1 Masao Honda,4 Takashi Wada,5 Shigeyuki Matsui,3 Shuichi Kaneko,1,4 and Yoshio Sakai4 1System Biology, Graduate School of Advanced Preventive Medical Sciences ... Akihiro Seki contributed to acquisition of data and analysis of data. Masao Honda and Takashi Wada contributed to analysis of data and interpretation of data. Shigeyuki Matsui and Shuichi Kaneko contributed

Light alcohol consumption has the potential to suppress hepatocellular injury and liver fibrosis in non-alcoholic fatty liver disease

, Hajime Sunagozaka, Shuichi Kaneko. Data curation: Kazutoshi Yamada, Eishiro Mizukoshi. Formal analysis: Kazutoshi Yamada, Masao Honda. Funding acquisition: Eishiro Mizukoshi, Shuichi Kaneko ... . Investigation: Kazutoshi Yamada, Takuya Seike, Hajime Sunagozaka, Tatsuya Yamashita. Methodology: Eishiro Mizukoshi. Project administration: Eishiro Mizukoshi, Masao Honda, Shuichi Kaneko. Resources: Rika Horii

Prognosis of type 1 autoimmune pancreatitis after corticosteroid therapy-induced remission in terms of relapse and diabetes mellitus

Kitamura, Kuniaki Arai, Taro Yamashita, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, Masao Honda, Shuichi Kaneko. Resources: Koichiro Matsuda, Taku Sanada, Takeshi Urabe, Katsuhisa Inamura, Takashi

Efficient Suppression of Hepatitis C Virus Replication by Combination Treatment with miR-122 Antagonism and Direct-acting Antivirals in Cell Culture Systems

Murai Takayoshi Shirasaki Masaya Funaki Masao Honda Seishi Murakami MinkyungYi Hong Tang Shuichi Kaneko OPEN Direct-acting antivirals (DAAs) against Hepatitis C virus (HCV) show effective antiviral

Potential efficacy of therapies targeting intrahepatic lesions after sorafenib treatment of patients with hepatocellular carcinoma

Background We investigated the contribution of subsequent therapy for advanced hepatocellular carcinoma refractory or intolerant to sorafenib. Further, we investigated the impact of sorafenib on overall survival using individual data. Methods We reviewed the medical records of patients with advanced hepatocellular carcinoma treated with sorafenib. Survival after sorafenib...

Genome-wide association study identified new susceptible genetic variants in HLA class I region for hepatitis B virus-related hepatocellular carcinoma

Nishida 10 11 17 Seik-Soon Khor 10 17 Masao Honda 12 17 Masaya Sugiyama 11 17 Natsumi 17 KayokoYamada 10 17 Norie Sawada 13 17 Shoichiro Tsugane 17 Kazuhiko Koike 13 14 17 Yuji Kondo 14 17 HiroshiYatsuhashi

microRNA-122 Abundance in Hepatocellular Carcinoma and Non-Tumor Liver Tissue from Japanese Patients with Persistent HCV versus HBV Infection

Mechanisms of hepatic carcinogenesis in chronic hepatitis B and hepatitis C are incompletely defined but often assumed to be similar and related to immune-mediated inflammation. Despite this, several studies hint at differences in expression of miR-122, a liver-specific microRNA with tumor suppressor properties, in hepatocellular carcinoma (HCC) associated with hepatitis B virus...

Peretinoin, an acyclic retinoid, improves the hepatic gene signature of chronic hepatitis C following curative therapy of hepatocellular carcinoma

Background The acyclic retinoid, peretinoin, has been shown to be effective for suppressing hepatocellular carcinoma (HCC) recurrence after definitive treatment in a small-scale randomized clinical trial. However, little has been documented about the mechanism by which peretinoin exerts its inhibitory effects against recurrent HCC in humans in vivo. Methods Twelve hepatitis C...

Small tRNA-derived RNAs are increased and more abundant than microRNAs in chronic hepatitis B and C

Jeanette Baran-Gale in:Nature Research journals • PubMed • Google ScholarSearch for Masao Honda in:Nature Research journals • PubMed • Google ScholarSearch for Daisuke Yamane in:Nature Research journals

The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial

Aims/hypothesis The cholesterol absorption inhibitor ezetimibe has been shown to ameliorate non-alcoholic fatty liver disease (NAFLD) pathology in a single-armed clinical study and in experimental animal models. In this study, we investigated the efficacy of ezetimibe on NAFLD pathology in an open-label randomised controlled clinical trial. Methods We had planned to enrol 80...

CD14+ Monocytes Are Vulnerable and Functionally Impaired Under Endoplasmic Reticulum Stress in Patients With Type 2 Diabetes

Takuya Komura Yoshio Sakai Masao Honda Toshinari Takamura Kouji Matsushima Shuichi Kaneko OBJECTIVE-Although patients with diabetes suffer from increased infections and a higher incidence of cancer

La Protein Required for Internal Ribosome Entry Site—Directed Translation Is a Potential Therapeutic Target for Hepatitis C Virus Replication

Background. Translation of the hepatitis C virus (HCV) is mediated by an internal ribosome entry site (IRES). Here, we analyzed the functional relevance of La protein for replication of HCV using an infectious HCV clone, JFH-1. Methods. A single-nucleotide mutation from A to U was introduced at the 338th nucleotide in the stem-loop domain IV structure of HCV IRES, which...

Expression Profiling of Peripheral-Blood Mononuclear Cells from Patients with Chronic Hepatitis C Undergoing Interferon Therapy

BackgroundInterferon (IFN) is now the standard treatment for chronic hepatitis C (CH-C); however, treatment efficacy is unpredictable before IFN therapy is started MethodsWe investigated the gene-expression profiles of peripheral-blood mononuclear cells (PBMCs) from patients with CH-C showing different responses to IFN. Gene-expression profiles of PBMCs were analyzed in 21...

Gene Systems Network Inferred from Expression Profiles in Hepatocellular Carcinogenesis by Graphical Gaussian Model

Hepatocellular carcinoma (HCC) in a liver with advanced-stage chronic hepatitis C (CHC) is induced by hepatitis C virus, which chronically infects about 170 million people worldwide. To elucidate the associations between gene groups in hepatocellular carcinogenesis, we analyzed the profiles of the genes characteristically expressed in the CHC and HCC cell stages by a statistical...

A randomized phase II trial of intra-arterial chemotherapy using SM-11355 (Miriplatin) for hepatocellular carcinoma

Background SM-11355 is a platinum complex developed to treat hepatocellular carcinoma (HCC) via administration into the hepatic artery as a sustained-release suspension in iodized oil. We conducted a multicenter phase II trial in patients with HCC to evaluate the efficacy and safety of SM-11355, using a Zinostatin stimalamer suspension in iodized oil as a reference. Methods...

Genome-wide association study identified ITPA/DDRGK1 variants reflecting thrombocytopenia in pegylated interferon and ribavirin therapy for chronic hepatitis C

Hematologic abnormalities during current therapy with pegylated interferon and ribavirin (PEG-IFN/RBV) for chronic hepatitis C (CHC) often necessitate dose reduction and premature withdrawal from therapy. The aim of this study was to identify host factors associated with IFN-induced thrombocytopenia by genome-wide association study (GWAS). In the GWAS stage using 900K single...

New Susceptibility and Resistance HLA-DP Alleles to HBV-Related Diseases Identified by a Trans-Ethnic Association Study in Asia

Tatsuya Ide Kazuhide Yamamoto Isao Sakaida Yoshikazu Murawaki Yoshito Itoh Akihiro Tamori Etsuro Orito Yoichi Hiasa Masao Honda Shuichi Kaneko Eiji Mita Kazuyuki Suzuki Keisuke Hino Eiji Tanaka Satoshi