Advanced search    

Search: authors:"Masashi Hirooka"

12 papers found.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

New diagnostic technique to evaluate hepatic steatosis using the attenuation coefficient on ultrasound B mode

) Author Contributions Conceptualization: Masashi Hirooka, Yoichi Hiasa. Data curation: Yohei Koizumi, Masashi Hirooka. Formal analysis: Yohei Koizumi, Osamu Nakashima. Supervision: Nobuharu Tamaki

Stimulated hepatic stellate cell promotes progression of hepatocellular carcinoma due to protein kinase R activation

: Yusuke Imai, Osamu Yoshida, Takao Watanabe, Atsushi Yukimoto, Yohei Koizumi, Yoshio Ikeda, Yoshio Tokumoto, Masashi Hirooka, Masanori Abe, Yoichi Hiasa. Funding acquisition: Osamu Yoshida, Yoichi Hiasa

Depletion of B cell-activating factor attenuates hepatic fat accumulation in a murine model of nonalcoholic fatty liver disease

Watanabe osamu Yoshida Masashi Hirooka Bunzo Matsuura Yoichi Hiasa obesity-induced adipose-tissue dysfunction is a critical contributor to the pathogenesis of nonalcoholic fatty liver disease (NAFLD). B

Cigarette smoking is a risk factor for the onset of fatty liver disease in nondrinkers: A longitudinal cohort study

, Teruki Miyake, Masashi Hirooka. Supervision: Teruki Miyake. Writing ± original draft: Masashi Okamoto. Writing ± review & editing: Teruki Miyake. 11 / 13 12 / 13 1. Angulo P . Nonalcoholic fatty liver ... . Data curation: Masashi Okamoto, Teruki Miyake, Kohichiro Kitai, Shin Yamamoto, Hidenori Senba, Sayaka Kanzaki, Akiko Deguchi, Mitsuhito Koizumi, Toru Ishihara, Hiroaki Miyaoka, Osamu Yoshida, Masashi

Downregulation of ANP32B exerts anti-apoptotic effects in hepatocellular carcinoma

The acidic (leucine-rich) nuclear phosphoprotein 32 family member B (ANP32B), a highly conserved member of the acidic nuclear phosphoprotein 32 (ANP32) family, is critical for the development of normal tissue. However, its role in the development of hepatocellular carcinoma (HCC) is controversial. In this study, we elucidated the role of ANP32B in HCC cell lines and tissues...

Usefulness of a New Three-Dimensional Simulator System for Radiofrequency Ablation

Multipuncture radiofrequency ablation is expected to produce a large ablated area and reduce intrahepatic recurrence of hepatocellular carcinoma; however, it requires considerable skill. This study evaluated the utility of a new simulator system for multipuncture radiofrequency ablation. To understand positioning of multipuncture electrodes on three-dimensional images, we...

Simeprevir with peginterferon/ribavirin for patients with hepatitis C virus genotype 1: high frequency of viral relapse in elderly patients

Purpose The tolerability and efficacy of simeprevir in combination with peginterferon and ribavirin in patients infected with hepatitis C virus (HCV) genotype 1 under actual clinical conditions were investigated. Methods A total of 176 patients with chronic HCV genotype 1 infection were treated with simeprevir for 12 weeks plus Peg-IFN/RBV for 24 weeks. Overall, 107 (60.7...

Hyperuricemia Is a Risk Factor for the Onset of Impaired Fasting Glucose in Men with a High Plasma Glucose Level: A Community-Based Study

Background It is not clear whether elevated uric acid is a risk factor for the onset of impaired fasting glucose after stratifying by baseline fasting plasma glucose levels. We conducted a community-based retrospective longitudinal cohort study to clarify the relationship between uric acid levels and the onset of impaired fasting glucose, according to baseline fasting plasma...

Protein Kinase R Modulates c-Fos and c-Jun Signaling to Promote Proliferation of Hepatocellular Carcinoma with Hepatitis C Virus Infection

Double-stranded RNA-activated protein kinase R (PKR) is known to be upregulated by hepatitis C virus (HCV) and overexpressed in hepatocellular carcinoma (HCC). However, the precise roles of PKR in HCC with HCV infection remain unclear. Two HCV replicating cell lines (JFH-1 and H77s), generated by transfection of Huh7.5.1 cells, were used for experiments reported here. PKR...

Muscle atrophy as pre-sarcopenia in Japanese patients with chronic liver disease: computed tomography is useful for evaluation

Background/Aim The definition of muscle atrophy (pre-sarcopenia) and its diagnostic criteria have not been well reported. To elucidate the frequency of pre-sarcopenia in chronic liver disease (CLD), we examined clinical features of Japanese CLD patients using abdominal computed tomography (CT) findings. Methods We enrolled 988 CLD (736 with naïve hepatocellular carcinoma) and 372...

Improvement of long-term outcomes in pancreatic cancer and its associated factors within the gemcitabine era: a collaborative retrospective multicenter clinical review of 1,082 patients

Background Although the outcomes of pancreatic cancer have been improved by gemcitabine, the changes in its characteristics and long-term outcomes within the gemcitabine era remain unclear. This study was conducted to identify clinical characteristics of pancreatic cancer patients within the gemcitabine era. Methods A retrospective chart review was performed at 10 centers for 1...

Improvement of long-term outcomes in pancreatic cancer and its associated factors within the gemcitabine era: a collaborative retrospective multicenter clinical review of 1,082 patients

Although the outcomes of pancreatic cancer have been improved by gemcitabine, the changes in its characteristics and long-term outcomes within the gemcitabine era remain unclear. This study was conducted to identify clinical characteristics of pancreatic cancer patients within the gemcitabine era. A retrospective chart review was performed at 10 centers for 1,248 consecutive...