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Independent, Controllable Stretch-Perfusion Bioreactor Chambers to Functionalize Cell-Seeded Decellularized Tendons

, Daniele D’Arrigo, Matteo Moretti, and Arianna B. Lovati have equally contributed to this work. Electronic supplementary material The online version of this article ( https://doi.org/10.1007/s10439-019-02257

Injective mesenchymal stem cell-based treatments for knee osteoarthritis: from mechanisms of action to current clinical evidences

PurposeOsteoarthritis (OA) represents a relevant social and economic burden worldwide. “Mesenchymal stem cells” or, as recently proposed, “medicinal signaling cells” (MSCs) have been recently introduced as injective treatments for OA with the aim of restoring joint homeostasis. The aim of this review is to provide the reader with the tools necessary to interpret the currently...

Translational Application of Microfluidics and Bioprinting for Stem Cell-Based Cartilage Repair

Correspondence should be addressed to Matteo Moretti; ti.otanodnasoppurg@itterom.oettam Received 14 July 2017; Revised 6 November 2017; Accepted 5 December 2017; Published 20 February 2018 Academic Editor

Decellularized and Engineered Tendons as Biological Substitutes: A Critical Review

Tendon ruptures are a great burden in clinics. Finding a proper graft material as a substitute for tendon repair is one of the main challenges in orthopaedics, for which the requirement of a biological scaffold would be different for each clinical application. Among biological scaffolds, the use of decellularized tendon-derived matrix increasingly represents an interesting...

Catch-and-Release of Target Cells Using Aptamer-Conjugated Electroactive Zwitterionic Oligopeptide SAM

Nucleic acid aptamers possess attractive features such as specific molecular recognition, high-affinity binding, and rapid acquisition and replication, which could be feasible components for separating specific cells from other cell types. This study demonstrates that aptamers conjugated to an oligopeptide self-assembled monolayer (SAM) can be used to selectively trap human...

Interstitial Perfusion Culture with Specific Soluble Factors Inhibits Type I Collagen Production from Human Osteoarthritic Chondrocytes in Clinical-Grade Collagen Sponges

Articular cartilage has poor healing ability and cartilage injuries often evolve to osteoarthritis. Cell-based strategies aiming to engineer cartilaginous tissue through the combination of biocompatible scaffolds and articular chondrocytes represent an alternative to standard surgical techniques. In this context, perfusion bioreactors have been introduced to enhance cellular...

Direct but not indirect co-culture with osteogenically differentiated human bone marrow stromal cells increases RANKL/OPG ratio in human breast cancer cells generating bone metastases

Chiara Arrigoni Paola De Luca 0 Mara Gilardi 0 Sara Previdi Massimo Broggini Matteo Moretti 0 0 Cell and Tissue Engineering Lab, IRCCS Istituto Ortopedico Galeazzi , Via R. Galeazzi 4, 20161 Milano