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Far from the Eyes, Close to the Heart: Dysbiosis of Gut Microbiota and Cardiovascular Consequences

Ethics Guidelines Conflict of Interest Matteo Serino, Vincent Blasco-Baque, and Simon Nicolas declare that they have no conflict of interest. Remy Burcelin reports personal fees from Vaiomer, outside the

Associations between hepatic miRNA expression, liver triacylglycerols and gut microbiota during metabolic adaptation to high-fat diet in mice

Cardiovasculaires (I2MC) , Université Paul Sabatier (UPS), Toulouse , France 1 Institut National de la Santé et de la Recherche Médicale (Inserm) , Toulouse , France 2 Matteo Serino 3 Unité Mixte de Recherche

Intestinal permeability � a new target for disease prevention and therapy

Data are accumulating that emphasize the important role of the intestinal barrier and intestinal permeability for health and disease. However, these terms are poorly defined, their assessment is a matter of debate, and their clinical significance is not clearly established. In the present review, current knowledge on mucosal barrier and its role in disease prevention and therapy...

Gut microbiota and diabetes: from pathogenesis to therapeutic perspective

More than several hundreds of millions of people will be diabetic and obese over the next decades in front of which the actual therapeutic approaches aim at treating the consequences rather than causes of the impaired metabolism. This strategy is not efficient and new paradigms should be found. The wide analysis of the genome cannot predict or explain more than 10–20% of the...

The gut microbiota profile is associated with insulin action in humans

The role of the gut microbiota in the induction of metabolic diseases has now been increasingly recognized worldwide. Indeed, a specific gut microbiota has been shown to characterize lean versus obese phenotypes both in humans and mice. We have also recently demonstrated that a precise gut microbiota is associated with the host’s responsiveness to a high-fat diet. Therefore, we...

High-Fat Diet Induces Periodontitis in Mice through Lipopolysaccharides (LPS) Receptor Signaling: Protective Action of Estrogens

Background A fat-enriched diet favors the development of gram negative bacteria in the intestine which is linked to the occurrence of type 2 diabetes (T2D). Interestingly, some pathogenic gram negative bacteria are commonly associated with the development of periodontitis which, like T2D, is characterized by a chronic low-grade inflammation. Moreover, estrogens have been shown to...

Resveratrol Increases Glucose Induced GLP-1 Secretion in Mice: A Mechanism which Contributes to the Glycemic Control

Resveratrol (RSV) is a potent anti-diabetic agent when used at high doses. However, the direct targets primarily responsible for the beneficial actions of RSV remain unclear. We used a formulation that increases oral bioavailability to assess the mechanisms involved in the glucoregulatory action of RSV in high-fat diet (HFD)-fed diabetic wild type mice. Administration of RSV for...

Lipid-Induced Peroxidation in the Intestine Is Involved in Glucose Homeostasis Imbalance in Mice

Background Daily variations in lipid concentrations in both gut lumen and blood are detected by specific sensors located in the gastrointestinal tract and in specialized central areas. Deregulation of the lipid sensors could be partly involved in the dysfunction of glucose homeostasis. The study aimed at comparing the effect of Medialipid (ML) overload on insulin secretion and...

Erratum to: Targeting the association of calgranulin B (S100A9) with insulin resistance and type 2 diabetes

Carlos III (ISCIII) , Pamplona , Spain and their affiliations is given below. Dr. Matteo Serino actively participated in the mice protocol by implanting subcutaneously osmotic minipumps filled either with

CD14 Modulates Inflammation-Driven Insulin Resistance

Jos Manuel Fernndez-Real Sofia Prez del Pulgar Elodie Luche Jos Maria Moreno-Navarrete Aurelie Waget Matteo Serino Eleonora Sorianello Alex Snchez-Pla Francesc Carmona Pontaque Joan Vendrell Matilde

Mice Heterozygous for Tumor Necrosis Factor-α Converting Enzyme Are Protected From Obesity-Induced Insulin Resistance and Diabetes

Matteo Serino Rossella Menghini Loredana Fiorentino Roberta Amoruso Alessandro Mauriello Davide Lauro Paolo Sbraccia Marta L. Hribal Renato Lauro Massimo Federici OBJECTIVE-Tumor necrosis factor

A role for adipocyte-derived lipopolysaccharide-binding protein in inflammation- and obesity-associated adipose tissue dysfunction

Aims/hypothesisCirculating lipopolysaccharide-binding protein (LBP) is an acute-phase reactant known to be increased in obesity. We hypothesised that LBP is produced by adipose tissue (AT) in association with obesity.Methods LBP mRNA and LBP protein levels were analysed in AT from three cross-sectional (n = 210, n = 144 and n = 28) and three longitudinal (n = 8, n = 25, n = 20...