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The immunological effect of Galectin-9/TIM-3 pathway after low dose Mifepristone treatment in mice at 14.5 day of pregnancy

contribution is dedicated to the 650th anniversary of the foundation of the University of PeÂcs, Hungary. Author Contributions Conceptualization: Beata Polgar. Data curation: Matyas Meggyes. Formal analysis ... : Matyas Meggyes. Funding acquisition: Laszlo Szereday. Investigation: Adrienn Lajko, Matyas Meggyes. 13 / 16 Methodology: Laszlo Szereday. Project administration: Laszlo Szereday. Writing ± original

Peripheral Blood TIM-3 Positive NK and CD8+ T Cells throughout Pregnancy: TIM-3/Galectin-9 Interaction and Its Possible Role during Pregnancy

Problem The T-cell immunoglobulin and mucin domain (TIM) family is a relatively newly described group of molecules with a conserved structure and important immunological functions. Identification of Galectin-9 as a ligand for TIM-3 has established the Galectin-9/TIM-3 pathway as an important negative regulator of Th1 immunity and tolerance induction. Data about the TIM-3/Gal-9...

Involvement of Galectin-9/TIM-3 Pathway in the Systemic Inflammatory Response in Early-Onset Preeclampsia

BackgroundPreeclampsia is a common obstetrical disease affecting 3-5% of pregnancies and representing one of the leading causes of both maternal and fetal mortality. Maternal symptoms occur as an excessive systemic inflammatory reaction in response to the placental factors released by the oxidatively stressed and functional impaired placenta. The T-cell immunoglobulin domain and...