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Search: authors:"Maurice Selman"

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Subclass-specific IgG glycosylation is associated with markers of inflammation and metabolic health

, Karli R. Reiding, Maurice Selman & Manfred WuhrerDepartment of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, The NetherlandsL. Renee RuhaakDepartment of Medical ... • Google Scholar Search for Hae-Won Uh in:Nature Research journals • PubMed • Google Scholar Search for Karli R. Reiding in:Nature Research journals • PubMed • Google Scholar Search for Maurice Selman

Pro-inflammatory pattern of IgG1 Fc glycosylation in multiple sclerosis cerebrospinal fluid

Background Immunoglobulin G (IgG) effector functions are regulated by the composition of glycans attached to a conserved N-glycosylation site in the Fc part. Intrathecal production of IgG, especially IgG1, is a hallmark of multiple sclerosis (MS), but nothing is known about IgG Fc glycosylation in MS and in cerebrospinal fluid (CSF) in general. Methods We applied mass...