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Extracellular vesicles are associated with the systemic inflammation of patients with seropositive rheumatoid arthritis

Patients with rheumatoid arthritis (RA) and autoantibodies, such as rheumatoid factor and those against cyclic citrullinated peptides, are designated as seropositive and have a more severe disease with worse prognosis than seronegative RA patients. Understanding the factors that participate in systemic inflammation, in addition to articular commitment, would allow better...

Senescence of bone marrow-derived mesenchymal stem cells from patients with idiopathic pulmonary fibrosis

BackgroundIdiopathic pulmonary fibrosis (IPF) is a chronic lung disease for which age is the most important risk factor. Different mechanisms associated with aging, including stem cell dysfunction, have been described to participate in the pathophysiology of IPF. We observed an extrapulmonary effect associated with IPF: increase in cell senescence of bone marrow-derived...

Procesos de formación en investigación en la Universidad: ¿qué le queda a los estudiantes?

? Processos de formação em investigação na Universidade: O que resta para os estudantes? Mauricio Rojas Betancur1  , Raquel Méndez Villamizar2  1Doctor en Ciencias Sociales. Profesor Titular

Procesos de formación en investigación en la Universidad: ¿qué le queda a los estudiantes?

? Processos de formação em investigação na Universidade: O que resta para os estudantes? Mauricio Rojas Betancur1  , Raquel Méndez Villamizar2  1Doctor en Ciencias Sociales. Profesor Titular

Procesos de formación en investigación en la Universidad: ¿qué le queda a los estudiantes?

? Processos de formação em investigação na Universidade: O que resta para os estudantes? Mauricio Rojas Betancur1  , Raquel Méndez Villamizar2  1Doctor en Ciencias Sociales. Profesor Titular

Procesos de formación en investigación en la Universidad: ¿qué le queda a los estudiantes?

? Processos de formação em investigação na Universidade: O que resta para os estudantes? Mauricio Rojas Betancur1  , Raquel Méndez Villamizar2  1Doctor en Ciencias Sociales. Profesor Titular

Procesos de formación en investigación en la Universidad: ¿qué le queda a los estudiantes?

? Processos de formação em investigação na Universidade: O que resta para os estudantes? Mauricio Rojas Betancur1  , Raquel Méndez Villamizar2  1Doctor en Ciencias Sociales. Profesor Titular

Procesos de formación en investigación en la Universidad: ¿qué le queda a los estudiantes?

? Processos de formação em investigação na Universidade: O que resta para os estudantes? Mauricio Rojas Betancur1  , Raquel Méndez Villamizar2  1Doctor en Ciencias Sociales. Profesor Titular

Endothelial Alterations in Systemic Lupus Erythematosus and Rheumatoid Arthritis: Potential Effect of Monocyte Interaction

Patients with systemic autoimmune diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are prone to develop atherosclerosis and cardiovascular diseases five times more often than the general population; this increase in frequency could be partially explained by an increase in the macrovasculature endothelial damage. In these autoimmune diseases, a...

Endothelial Alterations in Systemic Lupus Erythematosus and Rheumatoid Arthritis: Potential Effect of Monocyte Interaction

Patients with systemic autoimmune diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are prone to develop atherosclerosis and cardiovascular diseases five times more often than the general population; this increase in frequency could be partially explained by an increase in the macrovasculature endothelial damage. In these autoimmune diseases, a...

Regenerative medicine in the treatment of idiopathic pulmonary fibrosis: current position

Regenerative medicine in the treatment of idiopathic pulmonary fibrosis: current position Diana Álvarez,1,2 Melanie Levine,1 Mauricio Rojas1–3 1Dorothy P and Richard P Simmons Center for Interstitial Lung Disease, 2Pulmonary, Allergy, and Critical Care Medicine, 3McGowan Institute for Regenerative Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA Abstract...

Microparticles That Form Immune Complexes as Modulatory Structures in Autoimmune Responses

Microparticles (MPs) are induced during apoptosis, cell activation, and even “spontaneous” release. Initially MPs were considered to be inert cellular products with no biological function. However, an extensive research and functional characterization have shown that the molecular composition and the effects of MPs depend upon the cellular background and the mechanism inducing...

Mujer adolescente con acidemia metilmalónica y desenlace fatal

-Rodríguez1  César Mauricio Rojas-Maruri2  1Pediatra Internista, Encargado del Departamento de Medicina Interna, Instituto Nacional de Pediatría. 2Médico Patólogo adscrito al Servicio de Patología

PPD-induced monocyte mitochondrial damage is associated with a protective effect to develop tuberculosis in BCG vaccinated individuals: A cohort study

Introduction The mechanisms of mononuclear phagocyte death have been associated with the permissiveness and resistance to mycobacterial replication, but it remains unknown whether or not they help predict the risk of developing TB. Objective To describe the factors associated with the induction of monocyte mitochondrial and membrane damage in response to PPD as well as determine...

Infiltrating CD16

Burbano,1 Mauricio Restrepo,2 Adriana L. Vanegas,2 Carlos H. Muñoz,2 Mauricio Rojas,1 Luis A. González,2 and Gloria Vásquez1,2 1Grupo de Inmunología Celular e Inmunogenética, GICIG, Universidad de ... participated in data analysis of kidney biopsies and approved the final version of the manuscript. Catalina Burbano and Mauricio Rojas participated in data analysis of monocytes subsets and reviewed and approved

Infiltrating CD16

Burbano,1 Mauricio Restrepo,2 Adriana L. Vanegas,2 Carlos H. Muñoz,2 Mauricio Rojas,1 Luis A. González,2 and Gloria Vásquez1,2 1Grupo de Inmunología Celular e Inmunogenética, GICIG, Universidad de ... participated in data analysis of kidney biopsies and approved the final version of the manuscript. Catalina Burbano and Mauricio Rojas participated in data analysis of monocytes subsets and reviewed and approved

El género: una variable invisible pero sustantiva en la educación superior

Villamizar* Mauricio Rojas Betancur** *Mg. Estudios de Desarrollo, Universidad Industrial de Santander, Bucaramanga-Colombia **PhD. Ciencias Sociales Universidad Industrial de Santander, Bucaramanga

El género: una variable invisible pero sustantiva en la educación superior

Villamizar* Mauricio Rojas Betancur** *Mg. Estudios de Desarrollo, Universidad Industrial de Santander, Bucaramanga-Colombia **PhD. Ciencias Sociales Universidad Industrial de Santander, Bucaramanga