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Search: authors:"Max Plischke"

7 papers found.
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Augmented Backward Elimination: A Pragmatic and Purposeful Way to Develop Statistical Models

Statistical models are simple mathematical rules derived from empirical data describing the association between an outcome and several explanatory variables. In a typical modeling situation statistical analysis often involves a large number of potential explanatory variables and frequently only partial subject-matter knowledge is available. Therefore, selecting the most suitable...

Late Conversion of Kidney Transplant Recipients from Ciclosporin to Tacrolimus Improves Graft Function: Results from a Randomized Controlled Trial

Background Tacrolimus (TAC) to ciclosporin A (CSA) conversion studies in stable kidney transplant recipients have reported varying effects on graft function. Here we study graft function (eGFR) trajectories using linear mixed models, which provide effect estimates on both slope and baseline level of GFR and offer increased statistical power. Methods Secondary analysis of a...

Urine Osmolarity and Risk of Dialysis Initiation in a Chronic Kidney Disease Cohort – a Possible Titration Target?

Background Increasing evidence is linking fluid intake, vasopressin suppression and osmotic control with chronic kidney disease progression. Interestingly, the association between urine volume, urine osmolarity and risk of dialysis initiation has not been studied in chronic kidney disease patients before. Objective To study the relationship between urine volume, urine osmolarity...

Effect of oral sodium bicarbonate supplementation on progression of chronic kidney disease in patients with chronic metabolic acidosis: study protocol for a randomized controlled trial (SoBic-Study)

Background Overt chronic metabolic acidosis in patients with chronic kidney disease develops after a drop of glomerular filtration rate to less than approximately 25 mL/min/1.73 m2. The pathogenic mechanism seems to be a lack of tubular bicarbonate production, which in healthy individuals neutralizes the acid net production. As shown in several animal and human studies the...

TRANSPLANTATION BASIC SCIENCE, ALLOGENIC AND XENOGENIC TOLERANCE

Introduction and Aims: IgA nephropathy, the most common primary glomerulonephritis worldwide, can lead to end-stage renal disease and kidney transplantation. Disease recurrence frequently occurs after transplantation. We investigated the predictive value of three markers including galactose-deficient (Gd) IgA1, IgG anti-IgA autoantibodies, IgA-soluble (s) CD89 complexes for IgA...

Mineral and bone disease - CKD 5D

Introduction and Aims: In Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) patients, most treatment decisions concerning vitamin D use, administration of calcimimetics and parathyroidectomy are guided by parathyroid hormone (PTH) levels. The quality of the PTH test has been judged of paramount importance. Various fully automated assays are currently available, measuring...

Transplantation - clinical II

Introduction and Aims: Endothelial progenitor cells (EPCs) participate in regenerative processes of the vasculature, develop incompetence in several states of disease, and also have prognostic value. The effects of various immunosuppressants on EPCs are unknown. Methods: In an open-label, randomized controlled trial cyclosporine A (CSA) treated kidney transplant recipients (KTRs...