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Low-density lipoprotein cholesterol levels are associated with insulin-like growth factor-1 in short-stature children and adolescents: a cross-sectional study

Elevated low-density lipoprotein cholesterol (LDL-C) levels in childhood have recently been found to be the strongest predictive risk factor for coronary artery disease in adulthood. There is an increased level of LDL-C in children and adolescents with short stature. However, the underlying factors associated with increased LDL-C levels in children and adolescents with short...

Paracrine effects of CCN3 from non-cancerous hepatic cells increase signaling and progression of hepatocellular carcinoma

The liver microenvironment plays a key role in the progression and metastasis of hepatocellular carcinoma (HCC). Gene expression profiling of non-cancerous hepatic tissues obtained from patients with metastatic HCC exhibit a unique immune response signature, including upregulation of CCN3. However, the role of CCN3 secreted from non-cancerous hepatic tissues in the progression of...

Chemical Constituents from Mentha haplocalyx Briq. (Mentha canadensis L.) and Their α-Glucosidase Inhibitory Activities

Mentha haplocalyx (Mentha canadensis) is widely used as a medicinal plant in traditional Chinese medicine, and the extracts of its aerial parts are found to significantly inhibit the activity of α-glucosidase with an IC50 value of 21.0 μg/mL. Bioactivity-guided isolation of the extracts afforded two new compounds (1 and 2), together with 23 known ones (3–25). Their structures...

Anti-oral Microbial Flavanes from Broussonetia papyrifera Under the Guidance of Bioassay

A new flavane, bropapyriferol (1), and eleven known ones were isolated from the EtOAc part of Broussonetia papyrifera under the guidance of bioassay. The structure of compound 1 was determined by extensive 1D and 2D NMR, [α]D spectroscopic data and quantum computation. Daphnegiravan F (2) and 5,7,3′,4′-tetrahydroxy-3-methoxy-8,5′-diprenylflavone (3) showed significantly anti-oral...

Epidemiological characteristics of human rabies in Henan province in China from 2005 to 2013

 Lam 5   Ding Mei Zhang 1   Jia Hai Lu 1   *   1Department of Medical Statistic and Epidemiology, School of Public Health Zhongshan School of Medicine, Sun Yat-sen University, 74 Zhongshan

ATM Induces Cell Death with Autophagy in Response to H2O2 Specifically in Caenorhabditis elegans Nondividing Cells

Ministry of Education, Culture, Sports, Science and Technology of Japan (to Qiu-Mei Zhang-Akiyama). Supplementary Materials Supplementary Table: the primers used in this study. These primers were used for

ATM Induces Cell Death with Autophagy in Response to H2O2 Specifically in Caenorhabditis elegans Nondividing Cells

, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan Correspondence should be addressed to Qiu-Mei Zhang-Akiyama; pj.ca.u-otoyk.looz.oygnik@gnahzmq Received 23 February 2018; Revised 28 ... , Sports, Science and Technology of Japan (to Qiu-Mei Zhang-Akiyama). Supplementary Materials Supplementary Table: the primers used in this study. These primers were used for the verification of the atm-1

ATM Induces Cell Death with Autophagy in Response to H2O2 Specifically in Caenorhabditis elegans Nondividing Cells

, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan Correspondence should be addressed to Qiu-Mei Zhang-Akiyama; pj.ca.u-otoyk.looz.oygnik@gnahzmq Received 23 February 2018; Revised 28 ... , Sports, Science and Technology of Japan (to Qiu-Mei Zhang-Akiyama). Supplementary Materials Supplementary Table: the primers used in this study. These primers were used for the verification of the atm-1

Reliable design for virtual network requests with location constraints in edge-of-things computing

How to efficiently map virtual networks (VNs) onto a shared physical network is a challenging issue in the field of network virtualization in edge-of-things computing. Since an efficient VN mapping approach can reduce network resource consumption, lower latency, and enhance service reliability, it is important for both customers and network service providers. In this paper, we...

Elevated expression of human bHLH factor ATOH7 accelerates cell cycle progression of progenitors and enhances production of avian retinal ganglion cells

The production of vertebrate retinal projection neurons, retinal ganglion cells (RGCs), is regulated by cell-intrinsic determinants and cell-to-cell signaling events. The basic-helix-loop-helix (bHLH) protein Atoh7 is a key neurogenic transcription factor required for RGC development. Here, we investigate whether manipulating human ATOH7 expression among uncommitted progenitors...

Aberrant activation of Notch-1 signaling inhibits podocyte restoration after islet transplantation in a rat model of diabetic nephropathy

. Author information AffiliationsDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, ChinaYunqiang He, Mei Zhang, Ying Wu, Hemin Jiang ... for Yunqiang He in:Nature Research journals • PubMed • Google Scholar Search for Mei Zhang in:Nature Research journals • PubMed • Google Scholar Search for Ying Wu in:Nature Research journals • PubMed

Correction: Metabolic syndrome in Xinjiang Kazakhs and construction of a risk prediction model for cardiovascular disease risk

Wenwen Yang Jingyu Zhang Shugang Li Yunhua Hu Lati Mu Yizhong Yan Jiaolong Ma Yusong Ding Mei Zhang Jiaming Liu Rulin Ma Shuxia Guo In the Materials and Methods section, there is an error in the first

An Integrated FDD Approach for an Intensified HEX/Reactor

© 2018 Mei Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the

An Integrated FDD Approach for an Intensified HEX/Reactor

In this paper, a fault detection and diagnosis (FDD) scheme is developed for a class of intensified HEX/reactor, in which faults caused by sensor, actuator, and process are taken into account in the unified framework. By considering overall heat transfer coefficient as a function of fouling and fluid flow rate, a dynamic model which is capable of identifying these two faults...

Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells

Circulating monocytes can compete for virtually any tissue macrophage niche and become long-lived replacements that are phenotypically indistinguishable from their embryonic counterparts. As the factors regulating this process are incompletely understood, we studied niche competition in the brain by depleting microglia with >95% efficiency using Cx3cr1CreER/+R26DTA/+ mice and...

Identification of a rice metal tolerance protein OsMTP11 as a manganese transporter

Metal tolerance proteins (MTPs) are a gene family of cation efflux transporters that occur widely in plants and might serve an essential role in metal homeostasis and tolerance. Our research describes the identification, characterization, and localization of OsMTP11, a member of the MTP family from rice. OsMTP11 was expressed constitutively and universally in different tissues in...

Factors affecting medication adherence in community-managed patients with hypertension based on the principal component analysis: evidence from Xinjiang, China

Factors affecting medication adherence in community-managed patients with hypertension based on the principal component analysis: evidence from Xinjiang, China Yuji Zhang,* Xiaoju Li,* Lu Mao, Mei

In healthy volunteers, taking flucloxacillin with food does not compromise effective plasma concentrations in most circumstances

acquisition: Sharon J. Gardiner. Investigation: Sharon J. Gardiner, Philip G. Drennan, Mei Zhang, Jared K. Green, Heather L. Methodology: Sharon J. Gardiner, Ronald Begg, Richard J. Everts, Stephen T. Chambers ... ? review & editing: Philip G. Drennan, Ronald Begg, Mei Zhang, Jared K. Green, 13 / 14 1. Staphlex datasheet ( 07 January 2016 ), Mylan New Zealand Limited, Auckland, NZ. Available from: http

Impact of interactions among metabolic syndrome components on the development of cardiovascular disease among Kazakhs in Xinjiang

. Resources: Shuxia Guo. Software: Wenwen Yang, Xianghui Zhang, Jingyu Zhang, Shugang Li. Supervision: Wenwen Yang, Xiang Gao, Shuxia Guo. Validation: Yizhong Yan, Jiaolong Ma, Yusong Ding, Mei Zhang

The association of telomere attrition with first-onset stroke in Southern Chinese: a case-control study and meta-analysis

Zhang Weili Zhang OPEN Published: xx xx xxxx The relationship between telomere length and stroke was inconsistent mostly due to different pathogenesis of subtypes, environment and genetics. We aimed to