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New records of Tylokepon with the description of a new species (Epicaridea, Bopyridae, Keponinae)

The parasitic isopod genus Tylokepon is recorded for the first time from the Mariana Islands and Australia. Tylokepon marianensis sp. n. is described from the Mariana Islands, infesting Thusaenys irami (Laurie, 1906). The holotype female differs from other known Tylokepon females by the tri-lobed projection on pereomere 6, almost smooth lateral plates and pleopods, shape of...

Cannabinoid 2 receptor attenuates inflammation during skin wound healing by inhibiting M1 macrophages rather than activating M2 macrophages

The anti-inflammatory properties of the cannabinoid 2 receptor (CB2R) in injury and inflammatory diseases have been widely substantiated. Specifically, the anti-inflammatory effect of CB2R may be achieved by regulating macrophage polarisation. Several research findings suggested that the activation of CB2R could attenuate inflammation by reducing pro-inflammatory M1 macrophage...

Energy Efficiency Design for Secure MISO Cognitive Radio Network Based on a Nonlinear EH Model

In this work, we investigate the secrecy energy efficiency (SEE) optimization problem for a multiple-input single-output (MISO) cognitive radio (CR) network based on a practical nonlinear energy-harvesting (EH) model. In particular, the energy receiver (ER) is assumed to be a potential eavesdropper due to the open architecture of a CR network with simultaneous wireless...

The Last Mile: Safety Management Implementation in Construction Sites

To deepen the understanding of the construction safety accidents rules as well as identify and cure the crux of construction safety management failures in China, we analyzed the status quo of safety management and identified the “last mile” problem, that is, the failure of implementation of the extensive legal and regulatory systems on the construction site. The safety factors...

Narrow-bandgap Nb2O5 nanowires with enclosed pores as high-performance photocatalyst

)Xiaofei Zhao (赵小菲)Jiannan Lin (林建楠)Na Li (李娜)Ziyang Huo (霍子扬)Zifeng Yan (闫子峰)Miao Zhang (张苗)Shi Hu (胡适) Articles First Online: 31 July 2018 Received: 27 March 2018 Accepted: 04 June 2018 16 ... and conversion. Miao Zhang received her PhD from the Institute of Chemistry, Chinese Academy of Sciences. After her postdoctoral research in Lawrence Berkeley National Laboratory (LBNL), she is

Ensilage of oats and wheatgrass under natural alpine climatic conditions by indigenous lactic acid bacteria species isolated from high-cold areas

. 41101244), a grant (No. 152300410037) from Henan Province of China. Author Contributions Conceptualization: Miao Zhang, Zhongfang Tan. Data curation: Miao Zhang. Formal analysis: Miao Zhang. Funding ... acquisition: Yanping Wang, Zhen Jiao, Zhongfang Tan. Investigation: Miao Zhang, Meiyan Cui. Resources: Miao Zhang, Xiaojie Wang. Software: Miao Zhang. Supervision: Zhongfang Tan. Writing ± original draft

Authorship attribution of source code by using back propagation neural network based on particle swarm optimization

Contributions Conceptualization: Qi Li. Data curation: Xinyu Yang. Funding acquisition: Guoai Xu. Investigation: Xinyu Yang, Qi Li. Methodology: Xinyu Yang, Guoai Xu, Qi Li, Yanhui Guo, Miao Zhang. Project ... administration: Xinyu Yang. Resources: Xinyu Yang, Miao Zhang. Software: Xinyu Yang. Supervision: Guoai Xu, Qi Li, Yanhui Guo, Miao Zhang. Validation: Xinyu Yang, Miao Zhang. Writing ± original draft: Xinyu

Absorption Characteristics of Combination Medication of Realgar and Indigo Naturalis: In Vitro Transport across MDCK-MDR1 Cells and In Vivo Pharmacokinetics in Mice after Oral Administration

Realgar and indigo naturalis are clinically combined to treat varieties of leukemia. Exploring the drug-drug interactions might be beneficial to find active substances and develop new targeted drugs. This study aimed at exploring the change of arsenic concentration in mice and across MDCK-MDR1 cells and the cytotoxicity on K562 cells when realgar and indigo naturalis were...

The soil seed bank of a rehabilitated draw-down zone and its similarity to standing vegetation in the Three Gorges Reservoir Area

The reverse seasonal flooding that resulted from the construction of the Three Gorges Project has induced a drastic degradation of draw-down zone vegetation and the seed bank in the reservoir. The composition and distribution of seed banks and their similarities to standing vegetation were determined through field investigations and germination experiments on the vegetation as...

Inhibition of GRP78 abrogates radioresistance in oropharyngeal carcinoma cells after EGFR inhibition by cetuximab

) Acknowledgments This study was supported by National Natural Science Foundation of China (No. 81402521). Author Contributions Conceptualization: Yuanjun Jiang, Qiao Qiao. Data curation: Ning Han, Miao Zhang ... . Resources: Guang Li, Qiao Qiao. 14 / 17 Software: Chaonan Sun, Chuyang Han. Supervision: Qiao Qiao. Validation: Ning Han, Miao Zhang. Visualization: Chuyang Han. Writing ± original draft: Chaonan Sun

Structural insights into the potency of SK channel positive modulators

Small-conductance Ca2+-activated K+ (SK) channels play essential roles in the regulation of cellular excitability and have been implicated in neurological and cardiovascular diseases through both animal model studies and human genetic association studies. Over the past two decades, positive modulators of SK channels such as NS309 and 1-EBIO have been developed. Our previous...

Clinical implications of pathological features of primary membranous nephropathy

The clinical outcome varies considerably in primary membranous nephropathy (pMN). Risk factors for kidney prognosis include ageing, male gender, persistent heavy proteinuria, decreased eGFR at presentation, persistent elevation of anti-PLA2R antibodies, no remission, and so on. It was controversial whether the histopathological features of pMN could predict treatment response and...

Freeze-drying of mammalian cells using trehalose: preservation of DNA integrity

The aim of this study was to investigate preservation of biomolecular structures, particularly DNA, in freeze-dried fibroblasts, after loading with trehalose via freezing-induced uptake. Cells were freeze-dried with trehalose alone or in a mixture of albumin and trehalose. Albumin was added to increase the glass transition temperature and storage stability. No viable cells were...

Survey on Driverless Train Operation for Urban Rail Transit Systems

The length of metro lines with driverless train operation (DTO) systems is increasing globally and is predicted to triple in the next 10 years. This paper gives the history and future trend of the DTO systems. The opportunities provided by the DTO systems, such as lower operation costs, increased capacity, and energy efficiency, are explained and the relevant research are...

Characterisation of Lamp2-deficient rats for potential new animal model of Danon disease

Danon disease (DD) is caused by the absence or malfunction of lysosomal-associated membrane protein 2 (LAMP2). Although Lamp2-deficient mice and DD patients have similar characteristics, these mice have clear limitations and are clinically inconsistent. The aim of our paper is to outline the characteristics of Lamp2-deficient rats and to contrast this model with currently...

The effects of the reverse seasonal flooding on soil texture within the hydro-fluctuation belt in the Three Gorges reservoir, China

Purpose The formation of the large hydro-fluctuation belt at the altitude of 145–175 m, following the construction of the Three Gorges Dam, developed from the terrestrial system in the Three Gorges reservoir. This research mainly concerned the effects of the resultant reverse seasonal flooding on soil texture. Materials and methods Four field experimental plots were designed with...

A density-based material balance equation for the analysis of liquid-rich natural gas systems

This study analytically cross examines the consistency among available zero-dimensional material balance equations (MBEs) for liquid-rich gas equations and derive a new simple yet rigorous MBE starting from governing equations applicable to these systems. We propose a new zero-dimensional (tank) material balance equation directly applicable to the analysis of liquid-rich (wet and...

Tracheid cell-wall structures and locations of (1 → 4)-β-d-galactans and (1 → 3)-β-d-glucans in compression woods of radiata pine (Pinus radiata D. Don)

Background Compression wood (CW) forms on the underside of tilted stems of coniferous gymnosperms and opposite wood (OW) on the upperside. The tracheid walls of these wood types differ structurally and chemically. Although much is known about the most severe form of CW, severe CW (SCW), mild CWs (MCWs), also occur, but less is known about them. In this study, tracheid wall...

Identification of a novel linear B-cell epitope using a monoclonal antibody against the carboxy terminus of the canine distemper virus nucleoprotein and sequence analysis of the identified epitope in different CDV isolates

The Nucleoprotein (NP) is the most abundant and highly immunogenic protein in canine distemper virus (CDV), playing an important role in CDV viral replication and assembly. In this study, a specific monoclonal antibody, named C8, was produced against the NP protein C terminal (amino acids 401–523). A linear N protein epitope was identified by subjecting a series of partially...

Frequency Reconfigurable Circular Patch Antenna with an Arc-Shaped Slot Ground Controlled by PIN Diodes

In this paper, a compact frequency reconfigurable circular patch antenna with an arc-shaped slot loaded in the ground layer is proposed for multiband wireless communication applications. By controlling the ON/OFF states of the five PIN diodes mounted on the arc-shaped slot, the effective length of the arc-shaped slot and the effective length of antennas current are changed, and...