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Accuracy of a fecal immunochemical test according to outside temperature and travel time

Accuracy of a fecal immunochemical test according to outside temperature and travel time Tobias Niedermaier,1,2 Korbinian Weigl,1–3 Anton Gies,2,4 Michael Hoffmeister,1 Hermann Brenner1,3,4 1Division

Flexible sigmoidoscopy in colorectal cancer screening: implications of different colonoscopy referral strategies

Flexible sigmoidoscopy (FS) screening reduces colorectal cancer incidence and mortality. Its potential to detect proximal neoplasms depends on colonoscopy referral. We estimated diagnostic performance of sigmoidoscopy using 12 different referral criteria in detecting colorectal cancer and advanced adenomas. Colonoscopy results from 14,947 participants of screening colonoscopy in...

Strongly enhanced colorectal cancer risk stratification by combining family history and genetic risk score

Strongly enhanced colorectal cancer risk stratification by combining family history and genetic risk score Korbinian Weigl,1,2 Jenny Chang-Claude,3,4 Phillip Knebel,5 Li Hsu,6 Michael Hoffmeister,1

Fecal Immunochemical Tests Combined With Other Stool Tests for Colorectal Cancer and Advanced Adenoma Detection: A Systematic Review

, Korbinian Weigl, Michael Hoffmeister & Hermann BrennerGerman Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Division of Preventive Oncology, Heidelberg, GermanyHermann ... for Korbinian Weigl in:Nature Research journals • PubMed • Google ScholarSearch for Michael Hoffmeister in:Nature Research journals • PubMed • Google ScholarSearch for Hermann Brenner in:Nature Research

Different definitions of CpG island methylator phenotype and outcomes of colorectal cancer: a systematic review

Contradictory results were reported for the prognostic role of CpG island methylator phenotype (CIMP) among colorectal cancer (CRC) patients. Differences in the definitions of CIMP were the most common explanation for these discrepancies. The aim of this systematic review was to give an overview of the published studies on CRC prognosis according to the different definitions of...

Colorectal cancer screening: the time to act is now

authors read and approved the final manuscript. Acknowledgements The work of Hermann Brenner and Michael Hoffmeister on colorectal cancer screening was funded in part by grants from the German Federal

Colorectal cancer screening: the time to act is now

Michael Hoffmeister on colorectal cancer screening was funded in part by grants from the German Federal Ministry of Education and Research, the German Research Council (Deutsche Forschungsgemeinschaft), the

Heritability Estimation using a Regularized Regression Approach (HERRA): Applicable to continuous, dichotomous or age-at-onset outcome

The popular Genome-wide Complex Trait Analysis (GCTA) software uses the random-effects models for estimating the narrow-sense heritability based on GWAS data of unrelated individuals without knowing and identifying the causal loci. Many methods have since extended this approach to various situations. However, since the proportion of causal loci among the variants is typically...

Pre- and post-diagnostic β-blocker use and lung cancer survival: A population-based cohort study

Beta-blockers have been associated with decreased cancer mortality. However, evidence for lung cancer is sparse and reported beneficial effects might be based on biased analyses. In this so far largest study we investigated the association between β-blocker use and lung cancer survival. Therefore, patients with a lung cancer diagnosis between April 1998 and December 2011 were...

Coding variants in NOD-like receptors: An association study on risk and survival of colorectal cancer

I. da Silva Filho. Funding acquisition: Pavel Vodicka, Jan Wehkamp, Kari Hemminki, Jenny Chang-Claude, Hermann Brenner, Michael Hoffmeister, Malcolm G. Dunlop, Alexander N. R. Weber. Investigation ... Wehkamp, Kari Hemminki, Jenny Chang-Claude, Hermann Brenner, Michael Hoffmeister, Malcolm G. Dunlop, Alexander N. R. Weber, Asta Fo?rsti. Resources: Stefanie Huhn, Pavel Vodicka, Jan Wehkamp, Kari Hemminki

No association of CpG island methylator phenotype and colorectal cancer survival: population-based study

Background:Previous studies have shown adverse effects of CpG island methylator phenotype (CIMP) on colorectal cancer (CRC) prognosis. However, sample sizes were often limited and only few studies were able to adjust for relevant molecular features associated with CIMP. The aim of this study was to investigate the impact of CIMP on CRC survival in a large population-based study...

Inter-Physician Variation in Follow-Up Colonoscopies after Screening Colonoscopy

Background and AimsSurveillance is an integral part of the colorectal cancer (CRC) screening process. We aimed to investigate inter-physician variation in follow-up procedures after screening colonoscopy in an opportunistic CRC screening program. MethodsA historical cohort study in the German statutory health insurance system was conducted. 55,301 individuals who underwent...

Genetic variant predictors of gene expression provide new insight into risk of colorectal cancer

Genome-wide association studies have reported 56 independently associated colorectal cancer (CRC) risk variants, most of which are non-coding and believed to exert their effects by modulating gene expression. The computational method PrediXcan uses cis-regulatory variant predictors to impute expression and perform gene-level association tests in GWAS without directly measured...

Adherence to Physician Recommendations for Surveillance in Opportunistic Colorectal Cancer Screening: The Necessity of Organized Surveillance

BackgroundLimited evidence exists on the utilization of surveillance colonoscopy in colorectal cancer (CRC) screening programs. We assessed adherence to physician recommendations for surveillance in opportunistic CRC screening in Germany. MethodsA follow-up study of screening colonoscopy participants in 2007-2009 in Saarland, Germany, was conducted using health insurance claims...

Repeat polymorphisms in ESR2 and AR and colorectal cancer risk and prognosis: results from a German population-based case-control study

Background Evidence has accumulated which suggests that sex steroids influence colorectal cancer development and progression. We therefore assessed the association of repeat polymorphisms in the estrogen receptor β gene (ESR2) and the androgen receptor gene (AR) with colorectal cancer risk and prognosis. Methods The ESR2 CA and AR CAG repeat polymorphisms were genotyped in 1798...

Sojourn Time of Preclinical Colorectal Cancer by Sex and Age: Estimates From the German National Screening Colonoscopy Database

affiliations: Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany (Hermann Brenner, Michael Hoffmeister); Central Research Institute of Ambulatory Health Care

Helicobacter pylori Infection and Colorectal Cancer Risk: Evidence From a Large Population-based Case-Control Study in Germany

. ACKNOWLEDGMENTS Author affiliations: Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany (Yan Zhang, Michael Hoffmeister, Melanie N. Weck, Hermann Brenner); and

Designing and implementation of an intelligent manufacturing system

Purpose: The goal of XPRESS is to establish a breakthrough for the factory of the future with a new flexible production concept based on the generic idea of “specialized intelligent process units” (“Manufactrons”) integrated in cross-sectoral learning networks for a customized production. XPRESS meets the challenge to integrate intelligence and flexibility at the “highest” level...

Meta-Analysis of Mismatch Repair Polymorphisms within the Cogent Consortium for Colorectal Cancer Susceptibility

In the last four years, Genome-Wide Association Studies (GWAS) have identified sixteen low-penetrance polymorphisms on fourteen different loci associated with colorectal cancer (CRC). Due to the low risks conferred by known common variants, most of the 35% broad-sense heritability estimated by twin studies remains unexplained. Recently our group performed a case-control study for...