Microsatellite DNAs that form non-B structures are implicated in replication fork stalling, DNA double strand breaks (DSBs) and human disease. Fanconi anemia (FA) is an inherited disorder in which mutations in at least nineteen genes are responsible for the phenotypes of genome instability and cancer predisposition. FA pathway proteins are active in the resolution of non-B DNA...
Xiaomi Chen 0 Guoqi Liu 0 Michael Leffak 0 0 Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University , Dayton, OH 45435 The specification of
Sobha Kamath 0 Michael Leffak 0 0 Department of Biochemistry and Molecular Biology, Wright State University , Dayton, OH 45435, USA The cell cycle-dependent, ordered assembly of protein
Leffak 0 0 Department of Biochemistry and Molecular Biology, Wright State University , 3640 Colonel Glenn Highway, Dayton, OH 45435 , USA Eukaryotic chromatin structure limits the initiation of DNA
Farruggia 4 Alessandra Santoro 9 Süreyya Savasan 8 Kathrin Scheckenbach 7 Jörg Schipper 7 Martin Wagenmann 7 Todd Lewis 2 Michael Leffak 2 Janice L. Farlow 1 Tatiana M. Foroud 1 Ellen Honisch 10 Dieter
Michael Leffak 0 Kettering Medical Center-Wright State University Clinical Molecular Genetics Laboratory , Dayton, OH 45435 , USA 1 Department of Biochemistry and Molecular Biology, Wright State University
The origin of replication of the c-myc gene in HeLa cells was previously identified at low resolution within 3.5 kb 5′ to the P1 promoter, based on replication fork polarity and the location of DNA nascent strands. To define the initiation events in the c-myc origin at higher resolution the template bias of nascent DNAs in a 12 kb c-myc domain has been analyzed by hybridization...