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9 papers found.
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FANCJ is essential to maintain microsatellite structure genome-wide during replication stress

Microsatellite DNAs that form non-B structures are implicated in replication fork stalling, DNA double strand breaks (DSBs) and human disease. Fanconi anemia (FA) is an inherited disorder in which mutations in at least nineteen genes are responsible for the phenotypes of genome instability and cancer predisposition. FA pathway proteins are active in the resolution of non-B DNA...

Activation of a human chromosomal replication origin by protein tethering

Xiaomi Chen 0 Guoqi Liu 0 Michael Leffak 0 0 Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University , Dayton, OH 45435 The specification of

Multiple sites of replication initiation in the human β-globin gene locus

Sobha Kamath 0 Michael Leffak 0 0 Department of Biochemistry and Molecular Biology, Wright State University , Dayton, OH 45435, USA The cell cycle-dependent, ordered assembly of protein

The histone deacetylase inhibitor trichostatin A alters the pattern of DNA replication origin activity in human cells

Leffak 0 0 Department of Biochemistry and Molecular Biology, Wright State University , 3640 Colonel Glenn Highway, Dayton, OH 45435 , USA Eukaryotic chromatin structure limits the initiation of DNA

AluY-mediated germline deletion, duplication and somatic stem cell reversion in UBE2T defines a new subtype of Fanconi anemia

Farruggia 4 Alessandra Santoro 9 Süreyya Savasan 8 Kathrin Scheckenbach 7 Jörg Schipper 7 Martin Wagenmann 7 Todd Lewis 2 Michael Leffak 2 Janice L. Farlow 1 Tatiana M. Foroud 1 Ellen Honisch 10 Dieter

Alteration of in vivo DNA synthesis in the alpha globin locus of chick embryo fibroblasts due to in vivo activity of Rous sarcoma virus pp60src

Michael Leffak 0 Kettering Medical Center-Wright State University Clinical Molecular Genetics Laboratory , Dayton, OH 45435 , USA 1 Department of Biochemistry and Molecular Biology, Wright State University

DNA Replication Initiates Non-Randomly at Multiple Sites Near the c-myc Gene in HeLa Cells

The origin of replication of the c-myc gene in HeLa cells was previously identified at low resolution within 3.5 kb 5′ to the P1 promoter, based on replication fork polarity and the location of DNA nascent strands. To define the initiation events in the c-myc origin at higher resolution the template bias of nascent DNAs in a 12 kb c-myc domain has been analyzed by hybridization...