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Estradiol-17β protects against hypoxia-induced hepatocyte injury through ER-mediated upregulation of Bcl-2 as well as ER-independent antioxidant effects

University, Seoul 151-742, KoreaJang Hern Lee AuthorsSearch for Min Young Lee in:Nature Research journals • PubMed • Google ScholarSearch for Sun Chul Jung in:Nature Research journals • PubMed • Google

Identification of novel substrates for human checkpoint kinase Chk1 and Chk2 through genome-wide screening using a consensus Chk phosphorylation motif

Checkpoint kinase 1 (Chk1) and Chk2 are effector kinases in the cellular DNA damage response and impairment of their function is closely related to tumorigenesis. Previous studies revealed several substrate proteins of Chk1 and Chk2, but identification of additional targets is still important in order to understand their tumor suppressor functions. In this study, we screened...

Menthol, a unique urinary volatile compound, is associated with chronic inflammation in interstitial cystitis

College of Medicine, Incheon, South KoreaJayoung Kim AuthorsSearch for Muhammad Shahid in:Nature Research journals • PubMed • Google Scholar Search for Min Young Lee in:Nature Research journals • PubMed