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Elevated Glycemic Gap Predicts Acute Respiratory Failure and In-hospital Mortality in Acute Heart Failure Patients with Diabetes

Diabetes is a common comorbidity in patients hospitalized for acute heart failure (AHF), but the relationship between admission glucose level, glycemic gap, and in-hospital mortality in patients with both conditions has not been investigated thoroughly. Clinical data for admission glucose, glycemic gap and in-hospital death in 425 diabetic patients hospitalized because of AHF...

ANO1 inhibits cardiac fibrosis after myocardial infraction via TGF-β/smad3 pathway

. AffiliationsDepartment of Geriatrics, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, ChinaYao Gao, Yan Mei Zhang, Li Jun Qian, Ming Chu, Jian Hong & Di Xu AuthorsSearch for Yao Gao in:Nature ... Search for Ming Chu in:Nature Research journals • PubMed • Google Scholar Search for Jian Hong in:Nature Research journals • PubMed • Google Scholar Search for Di Xu in:Nature Research journals • PubMed

Therapeutic efficacy and safety of PCSK9-monoclonal antibodies on familial hypercholesterolemia and statin-intolerant patients: A meta-analysis of 15 randomized controlled trials

Qian Yao Gao Yan Mei Zhang Ming Chu Jing Yao Di Xu OPEN Published: xx xx xxxx Proprotein convertase subtilisin/kexin9 monoclonal antibodies (PCSK9-mAb) have been studied intensively to identify their

Proteome profiling reveals novel biomarkers to identify complicated parapneumonic effusions

Chi-Ming Chu in:Nature Research journals • PubMed • Google Scholar Search for Li-Jane Shih in:Nature Research journals • PubMed • Google Scholar Search for Yu-Ching Liu in:Nature Research journals

Engineering optical mode ferromagnetic resonance in FeCoB films with ultrathin Ru insertion

Ferromagnetic resonance (FMR) in soft magnetic films (SMFs) to a large extent determines the maximum working frequency of magnetic devices. The FMR frequency (fr) in an optical mode is usually much higher than that in the corresponding acoustic mode for exchange coupled ferromagnet/nonmagnet/ferromagnet (FM/NM/FM) trilayers. In this study, we prepared a 50 nm FeCoB film with...

A Null Mutation of the Serotonin 6 Receptor Alters Acute Responses to Ethanol

The anatomical distribution and pharmacology of serotonin 6 receptors (5-HT6Rs) implicate them as contributors to the serotonergic regulation of complex behavior. To complement the limited range of pharmacological tools available to examine 5-HT6R function, we have generated a mouse line bearing a constitutive null mutation of the 5-HT6R gene. No perturbations of baseline...

Role of rat liver cytochrome P450 3A and 2D in metabolism of imrecoxib

Aim:To investigate the in vitro metabolism of imrecoxib in rat liver microsomes and to identify the cytochrome P450 (CYP) forms involved in its metabolism.Methods:Liver microsomes of Wistar rats were prepared using an ultracentrifuge. The in vitro metabolism of imrecoxib was studied by incubation with rat liver microsomes. To characterize the CYP forms involved in the 4′-methyl...

Formation of 4′-carboxyl acid metabolite of imrecoxib by rat liver microsomes

Aim:Imrecoxib is a novel and moderately selective COX-2 inhibitor. The aim of the present in vitro investigation was to study the formation of the major metabolite 4′-carboxylic acid imrecoxib (M2) and identify the enzyme(s) involved in the reaction.Methods:The formation of M2 was studied in rat liver cytosol in the absence or presence of liver microsomes. The formed metabolite...

Identification and characterization of a prevalent hepatitis B virus X protein mutant in Taiwanese patients with hepatocellular carcinoma

, Chang Gung Memorial Hospital, 199 Tung Hwa North Road, Taipei 105, TaiwanChau-Ting Yeh, Chien-Hong Shen, Dar-In Tai, Chia-Ming Chu & Yun-Fan LiawChang Gung University School of Medicine, Taipei 105 ... , TaiwanChau-Ting Yeh, Chien-Hong Shen, Dar-In Tai, Chia-Ming Chu & Yun-Fan Liaw AuthorsSearch for Chau-Ting Yeh in:Nature Research journals • PubMed • Google ScholarSearch for Chien-Hong Shen in:Nature Research