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33 papers found.
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Injectable polypeptide hydrogel/inorganic nanoparticle composites for bone tissue engineering

-Shun Huang. 13 / 17 Methodology: Wei-Shun Huang. Project administration: Wei-Shun Huang. Resources: Wei-Shun Huang. Software: Wei-Shun Huang. Supervision: Wei-Shun Huang, I-Ming Chu. Validation: Wei ... -Shun Huang. Visualization: Wei-Shun Huang. Writing ? original draft: Wei-Shun Huang. Writing ? review & editing: Wei-Shun Huang, I-Ming Chu. 14 / 17 21. 15 / 17 16 / 17 1. Liu G , Zhao L , Zhang W

TFDP3 regulates the apoptosis and autophagy in breast cancer cell line MDA-MB-231

; National Natural Science Foundation of China, 81603119 to Ming Chu; Leading Academic Discipline Project of Beijing Education Bureau, BMU20110254 to Ming Chu; Fostering Talents in Basic Science of the ... National Natural Science Foundation of China, J1030831/J0108 to Yuedan Wang and the Natural Science Foundation of Beijing Municipality, 7174316 to Ming Chu. The funders had no role in study design, data

Prediction of novel target genes and pathways involved in bevacizumab-resistant colorectal cancer

findings and determine their clinical applicability. Supporting information S1 Table. Down-regulated bevacizumab-resistant genes. (DOCX) 12 / 18 Conceptualization: Chien-Yu Huang, Chi-Ming Chu, Po-Li Wei ... . Data curation: Precious Takondwa Makondi, Chia-Hwa Lee, Yu-Jia Chang. Investigation: Precious Takondwa Makondi, Chi-Ming Chu, Po-Li Wei. S2 Table. Up-regulated genes. (DOCX) Author Contributions Formal

Prediction of novel target genes and pathways involved in irinotecan-resistant colorectal cancer

Background Acquired drug resistance to the chemotherapeutic drug irinotecan (the active metabolite of which is SN-38) is one of the significant obstacles in the treatment of advanced colorectal cancer (CRC). The molecular mechanism or targets mediating irinotecan resistance are still unclear. It is urgent to find the irinotecan response biomarkers to improve CRC patients’ therapy...

TFDP3 Regulates Epithelial-Mesenchymal Transition in Breast Cancer

Breast cancer remains a lethal disease to women due to lymph node metastasis, the tumor microenvironment, secondary resistance and other unknown factors. Several important transcription factors involved in this disease, such as PTEN, p53 and beta-catenin, have been identified and researched in-depth as candidates for targeted therapy in breast cancer. TFDP3 is a new, promising...

Survival factors of hospitalized out-of-hospital cardiac arrest patients in Taiwan: A retrospective study

: Chi-Ming Chu, Chi-Wen Chang. Validation: Hsin Chu, Chi-Ming Chu, Chi-Wen Chang. Visualization: Chi-Wen Chang. Writing ± original draft: Chung-Yu Lai. Writing ± review & editing: Hsin Chu, Chih-Hung ... Ku, Shih-Hung Tsai, Chi-Ming Chu, Chi Wen Chang. 10 / 12 community. J Am Coll Cardiol. 2004; 44(6): 1268±1275. https://doi.org/10.1016/j.jacc.2004.06.029 PMID: 15364331 11 / 12 35. 37. 31. 1

Epistasis Test in Meta-Analysis: A Multi-Parameter Markov Chain Monte Carlo Model for Consistency of Evidence

Conventional genome-wide association studies (GWAS) have been proven to be a successful strategy for identifying genetic variants associated with complex human traits. However, there is still a large heritability gap between GWAS and transitional family studies. The “missing heritability” has been suggested to be due to lack of studies focused on epistasis, also called gene–gene...

Effects of cancer-testis antigen, TFDP3, on cell cycle regulation and its mechanism in L-02 and HepG2 cell lines in vitro

Ding. Formal analysis: Yunshen Jiao, Lingyu Ding, Xiaofan Zhao. Investigation: Yunshen Jiao, Xi Chen, Zirui Gao, Likai Gao. Project administration: Yunshen Jiao, Ming Chu, Yuedan Wang. Resources: Jiarui ... Kang. Software: Yunshen Jiao, Lingyu Ding, Tieshan Wang. Supervision: Ming Chu, Yuedan Wang. Visualization: Lingyu Ding. Writing ± original draft: Yunshen Jiao. Writing ± review & editing: Lingyu

Circumferential Strain Can Be Used to Detect Lipopolysaccharide-Induced Myocardial Dysfunction and Predict the Mortality of Severe Sepsis in Mice

Background Sepsis-induced myocardial dysfunction is a common and severe complication of septic shock. However, conventional echocardiography often fails to reveal myocardial depression in severe sepsis. Recently, strain measurements based on speckle tracking echocardiography (STE) have been used to evaluate cardiac function. Aims To investigate the role of STE in detecting...

Albuminuria and neck circumference are determinate factors of successful accurate estimation of glomerular filtration rate in high cardiovascular risk patients

Lin, Shih-Tai Chang, Wei-Shiang Lin, Chang Min Chung, Yun-Wen Shih, Fu-Chi Chen, Fu-Kang Hu, Yi-Syuan Wu, Chi-Wen Chang, Chi-Ming Chu. Data curation: Po-Jen Hsiao, Hung-Che Lin, Shih-Tai Chang, Jen ... -Te Hsu, Wei-Shiang Lin, Chang-Min Chung, Jung-Jung Chang, Yun-Wen Shih, Fu-Chi Chen, Fu-Kang Hu, Yi Syuan Wu, Chi-Wen Chang, Chi-Ming Chu. Formal analysis: Po-Jen Hsiao, Jen-Te Hsu, Wei-Shiang Lin

Gene-Gene and Gene-Environment Interactions in Meta-Analysis of Genetic Association Studies

Extensive genetic studies have identified a large number of causal genetic variations in many human phenotypes; however, these could not completely explain heritability in complex diseases. Some researchers have proposed that the “missing heritability” may be attributable to gene–gene and gene–environment interactions. Because there are billions of potential interaction...

Differentiation of Malignant and Benign Incidental Breast Lesions Detected by Chest Multidetector-Row Computed Tomography: Added Value of Quantitative Enhancement Analysis

To retrospectively determine the association between breast lesion morphology and malignancy and to determine the optimal value of lesion enhancement (HU, Hounsfield units) to improve the diagnostic accuracy of breast cancer in patients with incidental breast lesions (IBLs). A total of 97 patients with 102 IBLs detected from July 2009 to December 2012 were enrolled in this study...

Involvement of DNA-PKcs in the Type I IFN Response to CpG-ODNs in Conventional Dendritic Cells in TLR9-Dependent or -Independent Manners

CpG-ODNs activate dendritic cells (DCs) to produce interferon alpha (IFNα) and beta (IFNβ). Previous studies demonstrated that Toll-like receptor 9 (TLR9) deficient DCs exhibited a residual IFNα response to CpG-A, indicating that yet-unidentified molecules are also involved in induction of IFNα by CpG-A. Here, we report that the catalytic subunit of DNA-dependent protein kinase...

Clinical and Molecular Characteristics of Neonatal Extended-Spectrum β-Lactamase-Producing Gram-Negative Bacteremia: A 12-Year Case-Control-Control Study of a Referral Center in Taiwan

Extended-spectrum β-lactamase (ESBL)-producing Gram-negative bacteremia (GNB) in the neonatal intensive care unit was characterized by comparison with two control groups: a susceptible control group and a general base population group over 2001 to 2012. The influence of ESBL production on mortality was studied in all study subjects and ESBL-GNB isolates were microbiologically...

Identification of Bacteriology and Risk Factor Analysis of Asymptomatic Bacterial Colonization in Pacemaker Replacement Patients

Background Recent researches revealed that asymptomatic bacterial colonization on PMs might be ubiquitous and increase the risk of clinical PM infection. Early diagnosis of patients with asymptomatic bacterial colonization could provide opportunity for targeted preventive measures. Objective The present study explores the incidence of bacterial colonization of generator pockets...

Differences in COPD Patient Care by Primary Family Caregivers: An Age-Based Study

Background Because Taiwan has the fastest aging rate among developed countries, care for the elderly is becoming more prominent in the country. Primary family caregivers play an important role in patient health and health promotion behavior. Chronic obstructive pulmonary disease (COPD), an age-related disease, is a major public health problem with high morbidity and mortality and...

Biological and Clinical Significance of MAD2L1 and BUB1, Genes Frequently Appearing in Expression Signatures for Breast Cancer Prognosis

To investigate the biologic relevance and clinical implication of genes involved in multiple gene expression signatures for breast cancer prognosis, we identified 16 published gene expression signatures, and selected two genes, MAD2L1 and BUB1. These genes appeared in 5 signatures and were involved in cell-cycle regulation. We analyzed the expression of these genes in relation to...

Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and Susceptibility to Osteoarthritis of the Knee: A Case-Control Study and Meta-Analysis

Background Studies of angiotensin-converting enzyme insertion/deletion (ACE I/D) polymorphisms and the risks of knee osteoarthritis (OA) have yielded conflicting results. Objective To determine the association between ACE I/D and knee OA, we conducted a combined case-control study and meta-analysis. Methods For the case-control study, 447 knee OA cases and 423 healthy controls...

Involvement of DNA-PKcs in the IL-6 and IL-12 Response to CpG-ODN Is Mediated by Its Interaction with TRAF6 in Dendritic Cells

CpG-ODN stimulates dendritic cells (DCs) to produce cytokines, which are important for pathogenesis of autoimmune disorders and vaccine strategy for cancer. CpG-ODN activates the TLR9/MyD88/TRAF6 cascade leading to activation of IKK-NF-κB and JNK, which are critical for production of pro-inflammatory cytokines. However, whether other molecules are involved in activation of CpG...

Incidence, Clinical Characteristics and Attributable Mortality of Persistent Bloodstream Infection in the Neonatal Intensive Care Unit

Background An atypical pattern of neonatal sepsis, characterized by persistent positive blood culture despite effective antimicrobial therapy, has been correlated with adverse outcomes. However, previous studies focused only on coagulate-negative staphylococcus infection. Methods All episodes of persistent bloodstream infection (BSI), defined as 3 or more consecutive positive...