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A New Perspective of Acupuncture: The Interaction among Three Networks Leads to Neutralization

Acupuncture has been used to treat multiple medical conditions, but whether the diverse effects of acupuncture are intrinsically linked and how they might be connected have yet to be determined. More and more researches have shown that acupuncture is a kind of nociceptive stimulus, which can cause inflammatory reaction in the sites of acupuncture and then further activate the...

Baicalein prevents 6-OHDA/ascorbic acid-induced calcium-dependent dopaminergic neuronal cell death

Medical Sciences, University of Macau, Taipa, Macao SAR, ChinaSheng-Fang Wang, Ming-Yue Wu, Cui-Zan Cai, Huanxing Su & Jia-Hong LuSchool of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong ... AuthorsSearch for Sheng-Fang Wang in:Nature Research journals • PubMed • Google Scholar Search for Liang-Feng Liu in:Nature Research journals • PubMed • Google Scholar Search for Ming-Yue Wu in:Nature Research

Binding sensitivity of adefovir to the polymerase from different genotypes of HBV: molecular modeling, docking and dynamics simulation studies

China (No 2009CB918502), and the National Natural Science Foundation of China (No 81001399). Author contribution Ming-yue ZHENG and Ai-long HUANG designed the study, supervised the research and revised

Clinical Characteristics and Risk Factors of an Outbreak with Scrub Typhus in Previously Unrecognized Areas, Jiangsu Province, China 2013

Scrub typhus, caused by Orientia tsutsugamushi, has emerged recently in Jingjiang City, China where the disease had not been known to exist. We analyzed epidemiological data, clinical characteristics and risk factors of scrub typhus outbreak in Jingjiang City, 2013. The 271 clinically diagnosed patients were predominantly farmers 50 to 69 years old and the peak of onset was early...

Diagnostic and prognostic role of serum protein peak at 6449 m/z in gastric adenocarcinoma based on mass spectrometry

Background:Gastric cancer (GC) is a highly aggressive cancer type associated with significant mortality owing to delayed diagnosis and non-specific symptoms observed in the early stages. Therefore, identification of novel specific GC serum biomarkers for screening purposes is an urgent clinical requirement.Methods:This study recruited a total of 432 serum samples from 296 GC...

Discovery of a new series of imidazo[1,2-a]pyridine compounds as selective c-Met inhibitors

acknowledged. Author contribution Bing XIONG, Jing AI and Dong-mei ZHAO designed the research; Tong-chao LIU, Xia PENG, Yu-chi MA and Yin-chun JI conducted the research; Dan-qi CHEN, Ming-yue ZHENG, Mao-sheng

Effect of Mild Hypothermia on the Coagulation-Fibrinolysis System and Physiological Anticoagulants after Cardiopulmonary Resuscitation in a Porcine Model

The aim of this study was to evaluate the effect of mild hypothermia on the coagulation-fibrinolysis system and physiological anticoagulants after cardiopulmonary resuscitation (CPR). A total of 20 male Wuzhishan miniature pigs underwent 8 min of untreated ventricular fibrillation and CPR. Of these, 16 were successfully resuscitated and were randomized into the mild hypothermia...

Effects of Ultraviolet-B Irradiance on Intraspecific Competition and Facilitation of Plants: Self-Thinning, Size Inequality, and Phenotypic Plasticity

(1) The effects of facilitation on the structure and dynamics of plant populations have not been studied so widely as competition. The UV-B radiation, as a typical environmental factor causing stress, may result in direct stress and facilitation. (2) The effects of UV-B radiation on intraspecific competition and facilitation were investigated based on the following three...

Efficacy and safety of electroacupuncture with different acupoints for chemotherapy-induced nausea and vomiting: study protocol for a randomized controlled trial

Background Many patients experience nausea and vomiting during chemotherapy treatment. Evidence demonstrates that electroacupuncture is beneficial for controlling chemotherapy-induced nausea and vomiting (CINV). However, the acupoint or matching acupoint with the best efficacy for controlling CINV still remains unidentified. Methods/Design This study consists of a randomized...

Efficacy differences of electroacupuncture with single acupoint or matching acupoints for chemotherapy-induced nausea and vomiting: study protocol for a randomized controlled trial

Previous studies have shown that acupuncture is beneficial for the alleviation of chemotherapy-induced nausea and vomiting. However, there is a lack of clinical evidence concerning the effects of acupoint-matching on chemotherapy-induced nausea and vomiting. This is a parallel randomized controlled trial to evaluate the occurrence of nausea and vomiting after chemotherapy (the...

Enhanced Biological Behavior of In Vitro Human Gingival Fibroblasts on Cold Plasma-Treated Zirconia

Objective To evaluate whether atmospheric-pressure dielectric-barrier-discharge plasma treatment of zirconia enhances its biocompatibility with human gingival fibroblasts. Materials and Methods The zirconia disks were divided into four groups and treated using helium atmospheric-pressure dielectric-barrier-discharge plasmas for 30, 60 or 90 s or left untreated. The surface...

Evaluation of the mechanisms of intron loss and gain in the social amoebae Dictyostelium

Background Spliceosomal introns are a common feature of eukaryotic genomes. To approach a comprehensive understanding of intron evolution on Earth, studies should look beyond repeatedly studied groups such as animals, plants, and fungi. The slime mold Dictyostelium belongs to a supergroup of eukaryotes not covered in previous studies. Results We found 441 precise intron losses in...

FOXP3 promotes tumor growth and metastasis by activating Wnt/β-catenin signaling pathway and EMT in non-small cell lung cancer

The role of cancer cell FOXP3 in tumorigenesis is conflicting. We aimed to study FOXP3 expression and regulation, function and clinical implication in human non-small cell lung cancer (NSCLC). One hundred and six patients with histologically-confirmed NSCLC who underwent surgery were recruited for the study. Tumor samples and NSCLC cell lines were used to examine FOXP3 and its...

Fundamental-Solution-Based Hybrid Element Model for Nonlinear Heat Conduction Problems with Temperature-Dependent Material Properties

The boundary-type hybrid finite element formulation coupling the Kirchhoff transformation is proposed for the two-dimensional nonlinear heat conduction problems in solids with or without circular holes, and the thermal conductivity of material is assumed to be in terms of temperature change. The Kirchhoff transformation is firstly used to convert the nonlinear partial...

Genetic variants in interferon-λ 4 influences HCV clearance in Chinese Han population

Recent many studies indicated a novel dinucleotide variant in ss469415590 (TT vs. ΔG) of interferon-λ 4 (IFNL4) gene strongly associated with hepatitis C virus clearance. To evaluate the impact and clinical usefulness of IFNL4 ss469415590 genotype on predicting both spontaneous HCV clearance and response to therapy in Chinese population, we genotyped 795 chronic HCV carriers, 460...

Grazoprevir and Elbasvir in Patients with Genotype 1 Hepatitis C Virus Infection: A Comprehensive Efficacy and Safety Analysis

conflict of interests. Authors’ Contributions Rongbin Yu and Peng Huang participated in the design of the study. Yinan Yao, Ming Yue, Mei Liu, and Feng Zang took charge of data collection and quality control ... . Yinan Yao, Jie Wang, and Hongbo Chen performed the statistical analysis. Jun Li and Yun Zhang contributed materials and analysis tools. Yinan Yao, Ming Yue, and Peng Huang wrote the paper. All authors