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Invasive meningococcal disease in Shanghai, China from 1950 to 2016: implications for serogroup B vaccine implementation

ChenDepartment of Zoology, University of Oxford, Oxford, United KingdomCharlene M. C. Rodrigues, Odile B. Harrison & Martin C. J. Maiden AuthorsSearch for Mingliang Chen in:Nature Research journals • PubMed ... The authors declare no competing interests. Corresponding authors Correspondence to Mingliang Chen or Min Chen or Martin C. J. Maiden. Electronic supplementary material Supplementary material

Reduction of Scan Time and Echo Time in 3D Time-of-Flight (TOF) MR Angiography, Using Reverse Elliptical Centric Dual-Echo Acquisition

In the conventional single-echo three dimension (3D) time-of-flight (TOF) magnetic resonance angiography (MRA), it always takes long scan time to obtain the good images. In addition, high-resolution MRA with flow compensation requires long echo time (TE). Here, a reverse elliptical centric dual-echo 3D TOF MRA pulse sequence was developed to reduce the scan time and minimize the...

Hydrogen Sulfide Mitigates Kidney Injury in High Fat Diet-Induced Obese Mice

Obesity is prevalent worldwide and is a major risk factor for the development and progression of kidney disease. Hydrogen sulfide (H2S) plays an important role in renal physiological and pathophysiological processes. However, whether H2S is able to mitigate kidney injury induced by obesity in mice remains unclear. In this study, we demonstrated that H2S significantly reduced the...

Carboxylic Acid Fullerene (C60) Derivatives Attenuated Neuroinflammatory Responses by Modulating Mitochondrial Dynamics

Fullerene (C60) derivatives, a unique class of compounds with potent antioxidant properties, have been reported to exert a wide variety of biological activities including neuroprotective properties. Mitochondrial dynamics are an important constituent of cellular quality control and function, and an imbalance of the dynamics eventually leads to mitochondria disruption and cell...

De Novo Assembly and Characterization of Early Embryonic Transcriptome of the Horseshoe Crab Tachypleus tridentatus

The horseshoe crab Tachypleus tridentatus is a unique marine species and a potential model for marine invertebrate. Limited genomic and transcriptional data are currently available to understand the molecular mechanisms underlying the embryonic development of T. tridentatus. Here, we reported for the first time the de novo transcriptome assembly for T. tridentatus at embryonic...

Polyhydroxylated fullerene attenuates oxidative stress-induced apoptosis via a fortifying Nrf2-regulated cellular antioxidant defence system

Polyhydroxylated fullerene attenuates oxidative stress-induced apoptosis via a fortifying Nrf2-regulated cellular antioxidant defence system Shefang Ye,1 Min Chen,1 Yuanqin Jiang,1,2 Mingliang Chen,3

Shifts in the Antibiotic Susceptibility, Serogroups, and Clonal Complexes of Neisseria meningitidis in Shanghai, China: A Time Trend Analysis of the Pre-Quinolone and Quinolone Eras

Background Fluoroquinolones have been used broadly since the end of the 1980s and have been recommended for Neisseria meningitidis prophylaxis since 2005 in China. The aim of this study was to determine whether and how N. meningitidis antimicrobial susceptibility, serogroup prevalence, and clonal complex (CC) prevalence shifted in association with the introduction and expanding...

RMDAP: A Versatile, Ready-To-Use Toolbox for Multigene Genetic Transformation

Background The use of transgenes to improve complex traits in crops has challenged current genetic transformation technology for multigene transfer. Therefore, a multigene transformation strategy for use in plant molecular biology and plant genetic breeding is thus needed. Methodology/Principal Findings Here we describe a versatile, ready-to-use multigene genetic transformation...

High-Density Three-Dimension Graphene Macroscopic Objects for High-Capacity Removal of Heavy Metal Ions

, Liqiong Wu, Shengqiang Qiu, Yufen Guo, Xiumei Geng, Mingliang Chen, Shutian Liao, Chao Zhu, Youpin Gong, Mingsheng Long, Jianbao Xu, Xiangfei Wei & Liwei LiuUniversity of Chinese Academy of Sciences, 19A ... Research journals • PubMed • Google ScholarSearch for Mingliang Chen in:Nature Research journals • PubMed • Google ScholarSearch for Shutian Liao in:Nature Research journals • PubMed • Google ScholarSearch

The Effect of the Potential PhoQ Histidine Kinase Inhibitors on Shigella flexneri Virulence

PhoQ/PhoP is an important two-component system that regulates Shigella virulence. We explored whether the PhoQ/PhoP system is a promising target for new antibiotics against S. flexneri infection. By using a high-throughput screen and enzymatic activity coupled assay, four compounds were found as potential PhoQ inhibitors. These compounds not only inhibited the activity of SF...

Interlayer catalytic exfoliation realizing scalable production of large-size pristine few-layer graphene

ChinaXiumei Geng, Yufen Guo, Dongfang Li, Weiwei Li, Chao Zhu, Xiangfei Wei, Mingliang Chen, Song Gao, Shengqiang Qiu, Youpin Gong, Liqiong Wu, Mingsheng Long, Gebo Pan & Liwei LiuInstitute of Physics, Chinese ... Research journals • PubMed • Google ScholarSearch for Xiangfei Wei in:Nature Research journals • PubMed • Google ScholarSearch for Mingliang Chen in:Nature Research journals • PubMed • Google ScholarSearch