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15 papers found.
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Plasma amino acid profile associated with fatty liver disease and co-occurrence of metabolic risk factors

Fatty liver disease (FLD) increases the risk of diabetes, cardiovascular disease, and steatohepatitis, which leads to fibrosis, cirrhosis, and hepatocellular carcinoma. Thus, the early detection of FLD is necessary. We aimed to find a quantitative and feasible model for discriminating the FLD, based on plasma free amino acid (PFAA) profiles. We constructed models of the...

Relationship between estimated glomerular filtration rate, albuminuria, and oxidant status in the Japanese population

Background In the general population, reported levels of oxidative stress and antioxidant potential seem to vary. The aim of this study was to investigate the levels of oxidant status markers in relation to estimated glomerular filtration rate (eGFR) and albuminuria in Japanese population. Methods Data were analyzed from 8335 individuals who underwent a general health screening...

A Novel Multivariate Index for Pancreatic Cancer Detection Based On the Plasma Free Amino Acid Profile

Background The incidence of pancreatic cancer (PC) continues to increase in the world, while most patients are diagnosed with advanced stages and survive <12 months. This poor prognosis is attributable to difficulty of early detection. Here we developed and evaluated a multivariate index composed of plasma free amino acids (PFAAs) for early detection of PC. Methods We conducted a...

The significance and robustness of a plasma free amino acid (PFAA) profile-based multiplex function for detecting lung cancer

Fumio Imamura Nobuhiro Saruki Akira Imaizumi 1 Hiroshi Yamamoto 1 Takashi Daimon Osamu Tochikubo Toru Mitsushima Minoru Yamakado Hideki Kimura 0 0 Division of Thoracic Diseases, Chiba Cancer Center , 666 ... . Competing interest Takashi Daimon, Osamu Tochikubo, and Minoru Yamakado have been consultants for Ajinomoto, Co., Inc. and receive consultancy fees from Ajinomoto, CO., Inc. Akira Imaizumi and Hiroshi

Possibility of multivariate function composed of plasma amino acid profiles as a novel screening index for non-small cell lung cancer: a case control study

Background The amino-acid balance in cancer patients often differs from that in healthy individuals, because of metabolic changes. This study investigated the use of plasma amino-acid profiles as a novel marker for screening non-small-cell lung cancer (NSCLC) patients. Methods The amino-acid concentrations in venous blood samples from pre-treatment NSCLC patients (n = 141), and...

Relationship between Blood Pressure and Chronic Kidney Disease in the Japanese Population: The Lower the Better Even in Individuals without Hypertension?

Nobukazu ISHIZAKA Yuko ISHIZAKA Ei-ichi TODA Ryozo NAGAI Minoru YAMAKADO In hypertensive subjects, it has been demonstrated that the lower the blood pressure, the lower the incidence of chronic kidney

Association Between Smoking, Hematological Parameters, and Metabolic Syndrome in Japanese Men

increase the circulating WBC count. NOBUKAZU ISHIZAKA, MD, PHD1 YUKO ISHIZAKA, MD, PHD2 EI-ICHI TODA, RMS2 RYOZO NAGAI, MD, PHD1 MINORU YAMAKADO, MD, PHD2 Changing Incidence of

Association between Obesity and Chronic Kidney Disease in Japanese: Differences in Gender and Hypertensive Status?

George SEKI Ryozo NAGAI Minoru YAMAKADO Obesity is a known risk factor for hypertension and diabetes, both of which ultimately promote renal dysfunction. In the current study, we investigated the

Association between Chronic Kidney Disease and Carotid Intima-Media Thickening in Individuals with Hypertension and Impaired Glucose Metabolism

-ichi TODA Kazuhiko KOIKE George SEKI Ryozo NAGAI Minoru YAMAKADO We investigated whether chronic kidney disease (CKD) was associated with carotid intima-media thickening in 1,351 male individuals

Association between Cigarette Smoking and Chronic Kidney Disease in Japanese Men

NAGAI Minoru YAMAKADO Cigarette smoking may affect urinary albumin excretion and the glomerular filtration rate in both diabetic and nondiabetic subjects. Here we investigated the association between

Replication of Prostate Cancer Risk Loci in a Japanese Case–Control Association Study

Background Two prostate cancer genome-wide scans in populations of European ancestry identified several genetic variants that are strongly associated with prostate cancer risk. The effect of these risk variants and their cumulative effect in other populations are unknown.

Hypertension Is the Most Common Component of Metabolic Syndrome and the Greatest Contributor to Carotid Arteriosclerosis in Apparently Healthy Japanese Individuals

ISHIZAKA Yuko ISHIZAKA Ei-Ichi TODA Hideki HASHIMOTO Ryozo NAGAI Minoru YAMAKADO The cluster of metabolic and hemodynamic risk factors known as metabolic syndrome is known to be a risk factor for ischemic

Novel, Objective, Multivariate Biomarkers Composed of Plasma Amino Acid Profiles for the Diagnosis and Assessment of Inflammatory Bowel Disease

Background Inflammatory bowel disease (IBD) is a chronic intestinal disorder that is associated with a limited number of clinical biomarkers. In order to facilitate the diagnosis of IBD and assess its disease activity, we investigated the potential of novel multivariate indexes using statistical modeling of plasma amino acid concentrations (aminogram). Methodology and Principal...

Plasma Free Amino Acid Profiling of Five Types of Cancer Patients and Its Application for Early Detection

Background Recently, rapid advances have been made in metabolomics-based, easy-to-use early cancer detection methods using blood samples. Among metabolites, profiling of plasma free amino acids (PFAAs) is a promising approach because PFAAs link all organ systems and have important roles in metabolism. Furthermore, PFAA profiles are known to be influenced by specific diseases...