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Search: authors:"Monika Trzpis"

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The problem of defecation disorders in children is underestimated and easily goes unrecognized: a cross-sectional study

, analyzed and interpreted data, and drafted the initial manuscript. Monika Trzpis: Dr. Trzpis conceptualized and designed the study, acquired data, interpreted data, and critically revised the manuscript for

Normal Rectal Filling Sensations in Patients with an Enlarged Rectum

BackgroundIncreased rectal volume is believed to be associated with diminished rectal sensation, i.e., rectal hyposensitivity.AimsTo demonstrate that patients with increased rectal volumes do not automatically have diminished rectal filling sensations.MethodsWe, retrospectively, observed 100 adult patients with defecation problems, and 44 healthy controls who had undergone...

The puborectal continence reflex: a new regulatory mechanism controlling fecal continence

PurposeFecal continence is maintained by voluntary and involuntary contraction of the anal sphincter, and voluntary contractions of puborectal muscle. We investigated whether the puborectal muscle can control fecal continence not only by voluntary contractions but also by involuntary contractions.MethodsWe performed anorectal function tests in 23 healthy subjects. The anorectal...

Subtypes and symptoms of fecal incontinence in the Dutch population: a cross-sectional study

PurposeTo study the distribution of subtypes and symptoms of fecal incontinence in the general Dutch population.MethodsWe performed a cross-sectional study in a representative sample of the general Dutch population. All respondents (N = 1259) completed the Groningen Defecation and Fecal Continence questionnaire. We assigned the respondents to a so-called healthy subgroup (n...

On the prevalence of constipation and fecal incontinence, and their co-occurrence, in the Netherlands

Purpose Numerous studies have investigated the prevalence of constipation and fecal incontinence (FI) in the general population and, even though these disorders are known to co-occur, they were studied independently of each other. Our aim was to investigate the prevalence of constipation and FI, and their co-occurrence, in the general population in the Netherlands. Methods We...

Use of the EGP-2/Ep-CAM promoter for targeted expression of heterologous genes in carcinoma derived cell lines

EGP-2, also known as Ep-CAM, is expressed at high levels on the surface of most carcinomas and is therefore considered an attractive target for anticancer strategies. To explore the mechanisms regulating the expression of EGP-2, sequences 3.4 kb upstream of the transcription start site were isolated and assayed for their ability to control the expression of the EGP-2 cDNA, the...