Advanced search    

Search: authors:"Motoki Iwasaki"

48 papers found.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

Plasma cytokine levels and the presence of colorectal cancer

volunteers for their support and participation in this study. Author Contributions Conceptualization: Masaki Yamaguchi. Data curation: Masaki Yamaguchi, Shin Okamura, Taiki Yamaji, Motoki Iwasaki. Funding ... acquisition: Masaki Yamaguchi. Investigation: Masaki Yamaguchi, Shin Okamura, Taiki Yamaji, Motoki Iwasaki. Resources: Taiki Yamaji, Motoki Iwasaki, Shoichiro Tsugane. Supervision: Shoichiro Tsugane, Vivek

Association between NAT2, CYP1A1, and CYP1A2 genotypes, heterocyclic aromatic amines, and prostate cancer risk: a case control study in Japan

Background Heterocyclic aromatic amines (HAAs) may confer prostate cancer risk; however, the evidence is inconclusive and the activity of HAA-metabolizing enzymes is modulated by gene variants. The purpose of our study was to determine whether there was evidence of an association between HAA intake, polymorphisms in NAT2, CYP1A1, and CYP1A2 and prostate cancer risk in Japanese...

Adult height and all-cause and cause-specific mortality in the Japan Public Health Center-based Prospective Study (JPHC)

Ihira, Norie Sawada, Shoichiro Tsugane. Formal analysis: Hikaru Ihira. Funding acquisition: Shoichiro Tsugane. Investigation: Norie Sawada, Motoki Iwasaki, Taiki Yamaji, Atsushi Goto, Mitsuhiko Noda ... , Hiroyasu Iso, Shoichiro Tsugane. Supervision: Shoichiro Tsugane. Writing ? original draft: Hikaru Ihira. Writing ? review & editing: Norie Sawada, Motoki Iwasaki, Taiki Yamaji, Atsushi Goto, Mitsuhiko

Genome-wide association study (GWAS) of ovarian cancer in Japanese predicted regulatory variants in 22q13.1

Fuse, Junichi Sugawara, Atsushi Shimizu, Akimune Fukushima, Asahi Hishida, Norihiro Furusyo, Mariko Naito, Kenji Wakai, Taiki Yamaji, Norie Sawada, Motoki Iwasaki, Shoichiro Tsugane, Yoshinori Murakami

Association between plasma concentrations of branched-chain amino acids and adipokines in Japanese adults without diabetes

AffiliationsEpidemiology and Prevention Group, Centre for Public Health Sciences, National Cancer Centre, Tokyo, JapanRyoko Katagiri, Atsushi Goto, Sanjeev Budhathoki, Taiki Yamaji, Motoki Iwasaki & Shoichiro ... for Yumiko Kato in:Nature Research journals • PubMed • Google Scholar Search for Motoki Iwasaki in:Nature Research journals • PubMed • Google Scholar Search for Shoichiro Tsugane in:Nature Research

Severe cervical flexion myelopathy with long tract signs: a case report and a review of literature

in:Nature Research journals • PubMed • Google ScholarSearch for Toshitada Miwa in:Nature Research journals • PubMed • Google ScholarSearch for Motoki Iwasaki in:Nature Research journals • PubMed • Google

Association of plasma C-reactive protein level with the prevalence of colorectal adenoma: the Colorectal Adenoma Study in Tokyo

Epidemiologic studies have identified a positive association between obesity and colorectal neoplasia. Adiposity induces systemic low-grade inflammation, which is commonly assessed with a sensitive biomarker, C-reactive protein (CRP). To understand the molecular mechanisms of obesity in the etiology of colorectal neoplasia, the present study was conducted in 782 adenoma cases and...

Perceived stress level and risk of cancer incidence in a Japanese population: the Japan Public Health Center (JPHC)-based Prospective Study

for Public Health Sciences, National Cancer Center, 5-1-1 Tsukiji Chuo-ku, Tokyo, 104-0045, JapanEiko Saito, Norie Sawada, Akihisa Hidaka, Taichi Shimazu, Taiki Yamaji, Atsushi Goto, Motoki Iwasaki ... Motoki Iwasaki in:Nature Research journals • PubMed • Google Scholar Search for Shizuka Sasazuki in:Nature Research journals • PubMed • Google Scholar Search for Weimin Ye in:Nature Research journals

Vitamin D Receptor Gene Polymorphism and the Risk of Colorectal Cancer: A Nested Case-Control Study

Epidemiological and experimental evidence suggest that vitamin D is protective against the risk of colorectal cancer. Polymorphisms in the gene encoding vitamin D receptor (VDR), which mediates most of the known cellular effects of vitamin D, have been suggested to alter this association. Here, using a tag SNP approach, we comprehensively evaluated the role of common genetic...

Alcohol consumption, genetic variants in the alcohol- and folate metabolic pathways and colorectal cancer risk: the JPHC Study

data for the work, drafting of the manuscript, and final approval of the version to be published; Shoichiro Tsugane, Motoki Iwasaki, Taiki Yamaji, Norie Sawada, Manami Inoue, Shizuka Sasazuki, and Taichi ... Iwasaki Norie Sawada Manami Inoue Shizuka Sasazuki Taichi Shimazu Shoichiro Tsugane OPEN The association between alcohol intake and colorectal cancer (CRC) may vary secondary to single nucleotide

Low back pain and patient-reported QOL outcomes in patients with adolescent idiopathic scoliosis without corrective surgery

Purpose To reveal the prevalence of low back pain (LBP) and association between LBP and patient-reported QOL outcomes (JOABPEQ and SRS-22r) in patients with adolescent idiopathic scoliosis (AIS) without corrective surgery. Methods Ninety-eight female patients with AIS without corrective surgery who answered JOABPEQ, SRS-22r, and VAS for LBP were included. The scores of all...

Interaction between Red Meat Intake and NAT2 Genotype in Increasing the Risk of Colorectal Cancer in Japanese and African Americans

Heterocyclic aromatic amines formed in cooked meat may be an underlying mechanism for the red meat-colorectal cancer (CRC) association. These compounds require bioactivaction by N-acetyltransferase 2 (NAT2). An interaction effect between red meat consumption and NAT2 in increasing CRC risk has been inconsistently reported in whites. We investigated this interaction in two...

Neighborhood Deprivation and Risk of Cancer Incidence, Mortality and Survival: Results from a Population-Based Cohort Study in Japan

Background In many developed countries, socioeconomic status is associated with cancer incidence and survival. However, research in Japan is sparse. We examined the association between neighborhood deprivation based on the Japanese Deprivation Index and the risk of incidence, mortality and survival from total and major cancers in the Japan Public Health Center-based Prospective...

Identification of IGFBP2 and IGFBP3 As Compensatory Biomarkers for CA19-9 in Early-Stage Pancreatic Cancer Using a Combination of Antibody-Based and LC-MS/MS-Based Proteomics

Pancreatic cancer is one of the most lethal tumors, and reliable detection of early-stage pancreatic cancer and risk diseases for pancreatic cancer is essential to improve the prognosis. As 260 genes were previously reported to be upregulated in invasive ductal adenocarcinoma of pancreas (IDACP) cells, quantification of the corresponding proteins in plasma might be useful for...

Dietary arsenic intake and subsequent risk of cancer: the Japan Public Health Center-based (JPHC) Prospective Study

Purpose Arsenic is a known human carcinogen and has been linked to adverse health outcomes, including cancer. However, the effects of arsenic exposure from food on health are still unknown. We researched to examine the association between arsenic exposure from food and incidence of cancer in a Japanese population. Methods We conducted a population-based prospective study in 90...

Association Between Plasma 25-Hydroxyvitamin D and Colorectal Adenoma According to Dietary Calcium Intake and Vitamin D Receptor Polymorphism

: Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan (Taiki Yamaji, Motoki Iwasaki, Shizuka Sasazuki, Shoichiro Tsugane); and Genetics

Adjustment of Cell-Type Composition Minimizes Systematic Bias in Blood DNA Methylation Profiles Derived by DNA Collection Protocols

Differences in DNA collection protocols may be a potential confounder in epigenome-wide association studies (EWAS) using a large number of blood specimens from multiple biobanks and/or cohorts. Here we show that pre-analytical procedures involved in DNA collection can induce systematic bias in the DNA methylation profiles of blood cells that can be adjusted by cell-type...

The utility of superficial abdominal reflex in the initial diagnosis of scoliosis: a retrospective review of clinical characteristics of scoliosis with syringomyelia

Background With increasing use of magnetic resonance imaging (MRI), underlying syringomyelia is increasingly found in patients with presumed idiopathic scoliosis. To determine the indications for MRI in the differential diagnosis of scoliosis, several clinical characteristics of syringomyelia have been reported. Neurological signs, particularly abnormal superficial abdominal...