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Clinical features and pathogenesis of membranoproliferative glomerulonephritis: a nationwide analysis of the Japan renal biopsy registry from 2007 to 2015

Background The incidence and age distribution of membranoproliferative glomerulonephritis (MPGN) vary throughout the world by race and ethnicity. We sought to evaluate the clinical features, pathogenesis, and age distribution of MPGN among a large nationwide data from the Japan Renal Biopsy Registry (J-RBR). Methods A cross-sectional survey of 593 patients with MPGN (types I and...

A grading system that predicts the risk of dialysis induction in IgA nephropathy patients based on the combination of the clinical and histological severity

Histological classification is essential in the clinical management of immunoglobulin A nephropathy (IgAN). However, there are limitations in predicting the prognosis of IgAN based on histological information alone, which suggests the need for better prognostic models. Therefore, we defined a prognostic model by combining the grade of clinical severity with the histological...

Spectrum of LMX1B mutations: from nail–patella syndrome to isolated nephropathy

Society of Pediatric Nephrology, and the Japanese Renal Pathology Society. Compliance with ethical standards Conflicts of interest Motoshi Hattori has received a research grant from Astellas Pharma and

A consensus statement on health-care transition of patients with childhood-onset chronic kidney diseases: providing adequate medical care in adolescence and young adulthood

, Hirokazu Okada, Motoshi Hattori, Masayuki Iwano, Yuko Akioka, Akira Ashida, Yukihiko Kawasaki, Hideyasu Kiyomoto, Mayumi Sako, Yoshio Terada, Daishi Hirano, Mikiya Fujieda, Shouichi Fujimoto, Takao Masaki

Corrigendum: Analysis of the genes responsible for steroid-resistant nephrotic syndrome and/or focal segmental glomerulosclerosis in Japanese patients by whole-exome sequencing analysis

sequencing analysis Daisuke Ogino Taeko Hashimoto Motoshi Hattori Noriko Sugawara Yuko Akioka Gen Tamiya Satoshi Makino Kentaro Toyota Tetsuo Mitsui Kiyoshi Hayasaka Since the publication of the above

2015 Japanese Society for Dialysis Therapy: Guidelines for Renal Anemia in Chronic Kidney Disease

Masakane Kazuhide Saito Masaomi Nangaku Motoshi Hattori Takahiro Suzuki Satoshi Morita Akira Ashida Yasuhiko Ito Takahiro Kuragano Yasuhiro Komatsu Ken Sakai Yoshiharu Tsubakihara Kazuhiko Tsuruya Terumasa ... Tokyo. Member (Japanese Society for Pediatric Nephrology): Motoshi Hattori, Department of Pediatric Nephrology, Tokyo Women’s Medical University. Member (invited): Takahiro Suzuki, Division of

2015 Japanese Society for Dialysis Therapy: Guidelines for Renal Anemia in Chronic Kidney Disease

of Nephrology and Endocrinology, The University of Tokyo. Member (Japanese Society for Pediatric Nephrology): Motoshi Hattori, Department of Pediatric Nephrology, Tokyo Women’s Medical University

Afadin is localized at cell–cell contact sites in mesangial cells and regulates migratory polarity

In kidney glomeruli, mesangial cells provide structural support to counteract for expansile forces caused by pressure gradients and to regulate the blood flow. Glomerular injury results in proliferation and aberrant migration of mesangial cells, which is the pathological characteristic of mesangial proliferative glomerulonephritis. To date, molecular changes that occur in...

Clinical guides for atypical hemolytic uremic syndrome in Japan

from Nippon Boehringer Ingelheim Co., Ltd. Motoshi Hattori received research funding from Astellas, and Chugai. Shuichi Ito received lecture fees from Alexion and received research funding from Astellas

LMX1B mutation with residual transcriptional activity as a cause of isolated glomerulopathy

Background Nail–patella syndrome (NPS) is a rare autosomal-dominant disorder caused by LMX1B mutation. In patients with the renal lesions typical of NPS without skeletal or nail findings, it is described as nail–patella-like renal disease (NPLRD). However, the pathogenesis of NPLRD is largely unknown.

Podocyte expression of nonmuscle myosin heavy chain-IIA decreases in idiopathic nephrotic syndrome, especially in focal segmental glomerulosclerosis

Background Previous studies have identified significant associations between the development of idiopathic focal segmental glomerulosclerosis (FSGS) and MYH9 encoding nonmuscle myosin heavy chain-IIA (NMMHC-IIA). However, these studies focused only on the linkage of MYH9 polymorphisms and development of FSGS. There have been no reports on pathological changes of NMMHC-IIA in...

Diagnostic criteria for atypical hemolytic uremic syndrome proposed by the joint committee of the Japanese society of nephrology and the Japan pediatric society

Fujimaru, Hiroshi Hataya, Motoshi Hattori, Yoshihiko Hidaka, Shinya Kaname, Masaomi Nangaku, Hirokazu Okada, Waichi Sato, Toshihiro Sawai, Takashi Yasuda, Yoko Yoshida (Adviser) and Yoshihiro Fujimura

Pre-dialysis chronic kidney disease in children: results of a nationwide survey in Japan

Background Chronic kidney disease (CKD) in children is a progressive and intractable condition that may severely impair the child's growth, development and quality of life. Epidemiological information on pediatric CKD, particularly in Asians, is scant.

Elevated urinary plasmin activity resistant to α2-antiplasmin in acute poststreptococcal glomerulonephritis

Background. A pathogenic role of intraglomerular plasmin bound to nephritogenic antigen (nephritis-associated plasmin receptor, NAPlr) and resistant to physiologic inhibitors such as α2-antiplasmin (α2-AP) has recently been proposed in acute poststreptococcal glomerulonephritis (APSGN). To confirm this concept, we analysed the urinary profile of plasmin cascade in APSGN patients...

Phenotypic Characteristics and Cyclin-Dependent Kinase Inhibitors Repression in Hyperplastic Epithelial Pathology in Idiopathic Focal Segmental Glomerulosclerosis

Motoshi Hattori in:Nature Research journals • PubMed • Google ScholarSearch for Katsumi Ito in:Nature Research journals • PubMed • Google ScholarSearch for Teruo Watanabe in:Nature Research journals

Japan Renal Biopsy Registry and Japan Kidney Disease Registry: Committee Report for 2009 and 2010

12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 Motoshi Hattori 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 Kazumasa ... (Department of Nephrology), Hiroshi Hataya Tokyo Womens Medical University (Department of Pediatric Nephrology), Motoshi Hattori, Kiyonobu Ishizuka, Noriko Sugawara Tokyo Womens Medical University (The Forth

Japan Renal Biopsy Registry: the first nationwide, web-based, and prospective registry system of renal biopsies in Japan

Background The Committee for the Standardization of Renal Pathological Diagnosis and the Working Group for Renal Biopsy Database of the Japanese Society of Nephrology started the first nationwide, web-based, and prospective registry system, the Japan Renal Biopsy Registry (J-RBR), to record the pathological, clinical, and laboratory data of renal biopsies in 2007. Methods The...

Paediatric nephrology - A

Introduction and Aims: Patients with acquired solitary kidney due to nephrectomy are known to have satisfactory renal prognosis. However, according to some recent reports, renal outcome of the patients with congenital solitary kidney is not so good as has been previously recognized. So, we retrospectively reviewed the renal outcome and extrarenal complications in the patients...

Paediatric nephrology II

Introduction and Aims: Renal interstitial fibrosis is a final common pathway in chronic kidney disease (CKD) progression, independent of its origin. Matrix metalloproteinases (MMPs) are known for their proteolytic activity, regulating extracellular matrix content and tissue remodeling. The increased serum levels of MMPs have been described both in children and adults with...