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A High-Sensitivity and Broad-Range SPR Glucose Sensor Based on Improved Glucose Sensitive Membranes

An improved glucose sensitive membrane (GSM) is prepared by immobilizing glucose oxidase (GOD) onto a mixture of silica mesocellular foams (SiMCFs) and SiO2 nanoparticles (SiNPs) and then trapping it in a polyvinyl alcohol (PVA) gel. The membrane is coated onto a gold-glass sheet to create a surface plasmon resonance (SPR) sensor. A series of experiments are conducted to...

Follicle-stimulating hormone inhibits cervical cancer via NF-κB pathway

Follicle-stimulating hormone inhibits cervical cancer via NF-kappaB pathway Xi Shi,1,* Shiwei Qiu,1,* Wei Zhuang,1,* Caiji Wang,1 Shili Zhang,1 Na Yuan,1 Fukang Yuan,2 Yuehua Qiao1 1The Institute of

Erythroleukemia cells acquire an alternative mitophagy capability

Innovation Center of Hematology, Jiangsu Key Laboratory for Stem Cell Research, Soochow University School of Medicine, Suzhou 215123, ChinaJian Wang, Yixuan Fang, Lili Yan, Na Yuan, Suping Zhang, Li Xu, Meilan ... for Lili Yan in:Nature Research journals • PubMed • Google ScholarSearch for Na Yuan in:Nature Research journals • PubMed • Google ScholarSearch for Suping Zhang in:Nature Research journals • PubMed

Nuclear localization of Beclin 1 promotes radiation-induced DNA damage repair independent of autophagy

Beclin 1 is a well-established core mammalian autophagy protein that is embryonically indispensable and has been presumed to suppress oncogenesis via an autophagy-mediated mechanism. Here, we show that Beclin 1 is a prenatal primary cytoplasmic protein but rapidly relocated into the nucleus during postnatal development in mice. Surprisingly, deletion of beclin1 in in vitro human...

A strong ‘filter’ effect of the East China Sea land bridge for East Asia’s temperate plant species: inferences from molecular phylogeography and ecological niche modelling of Platycrater arguta (Hydrangeaceae)

Background In East Asia, an increasing number of studies on temperate forest tree species find evidence for migration and gene exchange across the East China Sea (ECS) land bridge up until the last glacial maximum (LGM). However, it is less clear when and how lineages diverged in this region, whether in full isolation or in the face of post-divergence gene flow. Here, we...

Citreoviridin Enhances Atherogenesis in Hypercholesterolemic ApoE-Deficient Mice via Upregulating Inflammation and Endothelial Dysfunction

Vascular endothelial dysfunction and inflammatory response are early events during initiation and progression of atherosclerosis. In vitro studies have described that CIT markedly upregulates expressions of ICAM-1 and VCAM-1 of endothelial cells, which result from NF-κB activation induced by CIT. In order to determine whether it plays a role in atherogenesis in vivo, we conducted...

Comparative Study on Interface Elements, Thin-Layer Elements, and Contact Analysis Methods in the Analysis of High Concrete-Faced Rockfill Dams

This paper presents a study on the numerical performance of three contact simulation methods, namely, the interface element, thin-layer element, and contact analysis methods, through the analysis of the contact behavior between the concrete face slab and the dam body of a high concrete-faced rockfill dam named Tianshengqiao-I in China. To investigate the accuracy and limitations...

Bending Moment Calculations for Piles Based on the Finite Element Method

Using the finite element analysis program ABAQUS, a series of calculations on a cantilever beam, pile, and sheet pile wall were made to investigate the bending moment computational methods. The analyses demonstrated that the shear locking is not significant for the passive pile embedded in soil. Therefore, higher-order elements are not always necessary in the computation. The...

Bending Moment Calculations for Piles Based on the Finite Element Method

Using the finite element analysis program ABAQUS, a series of calculations on a cantilever beam, pile, and sheet pile wall were made to investigate the bending moment computational methods. The analyses demonstrated that the shear locking is not significant for the passive pile embedded in soil. Therefore, higher-order elements are not always necessary in the computation. The...

Ethanolic extract of propolis inhibits atherosclerosis in ApoE-knockout mice

Background The present study was undertaken to investigate the effects and underlying mechanism of ethanolic extract of propolis (EEP) on the development of atherosclerotic lesions in ApoE−/− mice. Methods Eight-week-old male ApoE−/− mice fed a high-fat diet were treated with EEP (160 mg/kg/d) or vehicle (the same dose) respectively for 14 weeks. The serum levels of total...

Autophagy confers DNA damage repair pathways to protect the hematopoietic system from nuclear radiation injury

. Author information Author notesWeiwei Lin & Na Yuan These authors contributed equally to this work. AffiliationsHematology Center of Cyrus Tang Medical Institute, Jiangsu Institute of Hematology ... , Collaborative Innovation Center of Hematology, Jiangsu Key Laboratory for Stem Cell Research, Soochow University School of Medicine, Suzhou 215123, ChinaWeiwei Lin, Na Yuan, Zhen Wang, Yan Cao, Yixuan Fang, Xin

Inhibitory effect of the combination therapy of simvastatin and pinocembrin on atherosclerosis in apoE-deficient mice

The present study was performed to investigate the effects of the combination therapy of pinocembrin and simvastatin on the atherosclerotic lesions development in the ApoE−/− mice. Methods Eight-week-old male ApoE−/− mice were fed high fat diet (HFD) and treated with simvastatin (10 mg/kg per day), pinocembrin (20 mg/kg per day), or the combination therapy (simvastatin 5 mg/kg...

Ordered Mesostructured CdS Nanowire Arrays with Rectifying Properties

Highly ordered mesoporous CdS nanowire arrays were synthesized by using mesoporous silica as hard template and cadmium xanthate (CdR2) as a single precursor. Upon etching silica, mesoporous CdS nanowire arrays were produced with a yield as high as 93 wt%. The nanowire arrays were characterized by XRD, N2adsorption, TEM, and SEM. The results show that the CdS products replicated...