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Effects of the levonorgestrel-containing intrauterine device, copper intrauterine device, and levonorgestrel-containing oral contraceptive on susceptibility of immune cells from cervix, endometrium and blood to HIV-1 fusion measured ex vivo

like to thank all study participants. Author Contributions McCune. Karen Smith-McCune. Conceptualization: Marielle Cavrois, Joan F. Hilton, Nadia R. Roan, Dominika Seidman, Sarah Averbach, Ruth ... SmithFunding acquisition: Marielle Cavrois, Joan F. Hilton, Ruth Greenblatt, Barbara L. Shacklett, Investigation: Marielle Cavrois, Nadia R. Roan, Margaret Takeda, Eric Chang, Nandhini Raman, Ruth Greenblatt

Semen inhibits Zika virus infection of cells and tissues from the anogenital region

-Philippe Herbeuval in:Nature Research journals • PubMed • Google Scholar Search for Jonas Schmidt-Chanasit in:Nature Research journals • PubMed • Google Scholar Search for Nadia R. Roan in:Nature Research

Interaction of Fibronectin With Semen Amyloids Synergistically Enhances HIV Infection

Semen harbors amyloids that enhance human immunodeficiency virus type 1 (HIV-1) infection. We set out to identify factors that bind these amyloids and to determine whether these factors modulate amyloid-mediated HIV-enhancing activity. Using biochemical and mass spectrometric approaches, we identified fibronectin as a consistent interaction partner. Although monomeric fibronectin...

Developmental Regulation of Chlamydia trachomatis Class I Accessible Protein–1, a CD8+ T Cell Antigen

In this report, we show that the Chlamydia trachomatis–specific CD8+ T cell antigen class I accessible protein–1 (Cap1) is expressed during the early stages of the C. trachomatis developmental cycle. We provide additional evidence suggesting that Cap1 may be important in early immune recognition of the organism. Understanding the temporal and spatial expression of CD8+ T cell...

Semen-mediated enhancement of HIV infection is donor-dependent and correlates with the levels of SEVI

Background HIV-1 is usually transmitted in the presence of semen. We have shown that semen boosts HIV-1 infection and contains fragments of prostatic acid phosphatase (PAP) forming amyloid aggregates termed SEVI (semen-derived enhancer of viral infection) that promote virion attachment to target cells. Despite its importance for the global spread of HIV-1, however, the effect of...

Semen-mediated enhancement of HIV infection is donor-dependent and correlates with the levels of SEVI

HIV-1 is usually transmitted in the presence of semen. We have shown that semen boosts HIV-1 infection and contains fragments of prostatic acid phosphatase (PAP) forming amyloid aggregates termed SEVI (semen-derived enhancer of viral infection) that promote virion attachment to target cells. Despite its importance for the global spread of HIV-1, however, the effect of semen on...